Acceleration of brown adipocyte differentiation and improvement of metabolic syndrome in aP2-Creg1 transgenic mice
| Project/Area Number |
16K21453
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
Metabolomics
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| Research Institution | Chubu University |
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Principal Investigator |
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| Research Collaborator |
YAMASHITA Hitoshi 中部大学, 生命健康科学部, 教授
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | CREG1 / UCP1 / 褐色脂肪 / メタボリックシンドローム / 分子病態学 / Creg1 |
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| Outline of Final Research Achievements |
Brown adipocyte differentiation was stimulated in adipose tissues and diet-induced obesity was reduced in aP2-CREG1-Tg mice under HFD feeding condition.In addition, oxygen consumption level was increased in aP2-CREG1-Tg mice after administration of β3-adrenergic receptor agonist, suggesting that thermogenic capacity is increased in these mice.Insulin resistance associated with diet-induced obesity was also improved in aP2-CREG1-Tg mice compared with WT mice.
These results suggest that CREG1 could be a novel endocrine factor with therapeutic potential for obesity and metabolic syndromes.
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Report
(3 results)
Research Products
(7 results)
