| Project/Area Number |
16K21462
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
Embryonic/Neonatal medicine
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| Research Institution | Aichi Medical University |
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Principal Investigator |
Muto Taichiro 愛知医科大学, 医学部, 講師 (80613695)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アレルギー / アレルギー誘導性サイトカイン / type 2 inflammation / 小児アレルギー / 乳児アレルギー性疾患 |
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| Outline of Final Research Achievements |
Various risks are considered for the development of allergic diseases in children depending on the internal environment. During pregnancy, high BMI, excessive weight gain, low maternal blood vitamin D concentration, environment such as maternal smoking, second-hand smoke, and the relationship between maternal allergic diseases and atopic dermatitis in children have been pointed out. There is. Newborns with high cord blood levels of TSLP and IL-33 are associated with maternal and infant features that reflect an increased risk of developing allergic disease, which is associated with potential inflammatory and allergic disorders. It could be a predictor. Although past reports have summarized the results of the above studies, this study did not reach the conclusion because there were problems in collecting sample numbers.
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| Academic Significance and Societal Importance of the Research Achievements |
アレルギー性疾患の日常管理で新たな指標となりえた。食物アレルギーをはじめとするアレルギー疾患患者でTSLPやIL-33は高値を示すことが考えらえれ、診断の一助となる。また、非常に迅速に変動することが考えられ、病勢を鋭敏に反映するマーカーとなる得るため、日常管理での治療薬の調節や経過予測に有用となる。アナフィラキシー経過での重症度判定、予後予測に使用できる可能性、また、アレルギー性疾患の発症予防、治療の標的となりえた。
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