Relationship between moxibustion-like stimulation and TRPV1
Project/Area Number |
16K21498
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General internal medicine(including psychosomatic medicine)
Applied health science
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Research Institution | Tokyo Ariake University of Medical and Health Sciences (2018-2019) Meiji University of Integrative Medicine (2016-2017) |
Principal Investigator |
Taniguchi Sazu 東京有明医療大学, 保健医療学部, 特別研究員 (60555655)
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Project Period (FY) |
2016-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Keywords | 灸 / TRPV1 / 熱刺激 / 膀胱 / 自律神経 / 灸刺激 / 膀胱機能 / ラット / DRG / オキシトシン / 室傍核 / 結腸運動 / 炎症 / セロトニン / 医療・福祉 / ストレス / 生理学 / 鍼灸学 / 東洋医学 |
Outline of Final Research Achievements |
Moxibustion is used for the treatment of a wide variety of disorders. It is thought that transient receptor potential vanilloid 1 (TRPV1) receptors, which presented in somatosensory nerves, are involved in moxibustion stimulation. However, the detailed mechanism is unknown. The purpose of this study was to investigate whether moxibustion-like stimuli changes bladder contraction, and whether the response is involved in TRPV1 in anesthetized rats. The stimulation temperature was set at 40, 45, and 50°C, and the stimulation was performed once to multiple times. As a result, bladder contraction increased in a temperature and frequency-dependent manner. Moreover, moxibustion-induced bladder contraction suppressed upon TRPV1 antagonist injection. These results suggest that the effect of moxibustion-like stimuli is determined by the activation of TRPV1, which is associated with the stimulation of C fivers, and is caused increase of bladder contraction via the somato-autonomic nerve reflex.
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Academic Significance and Societal Importance of the Research Achievements |
灸治療は古くから胃腸疾患や婦人科疾患、感冒などに用いられてきた経緯があり、近年も温活などで灸が再びブームとなっているが、その作用機序に不明な点は多い。作用機序を解明することは、不調を抱える人がその方法をより安全に効果的に利用できることにつながる。今回の結果では、皮膚への灸様刺激が膀胱機能に影響することがわかった。そこにはTRPV1受容体が関与していることが考えられ、この受容体が活性化する43℃以上の刺激が効果的に作用することが示唆された。
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Report
(5 results)
Research Products
(2 results)