Research Project
Grant-in-Aid for Young Scientists (B)
A synergistic study on computational fluid dynamics (CFD) simulation and sample preparation with highly branched cyclic dextrin (HBCD) as an excipient matrix for dry powder inhaler formulations were performed. Fine particles with HBCD were prepared by spray-drying. Regarding inhalational properties, HBCD formulations had higher emitted dose and fine-particle fractions than formulations of all other sugars tested. Our results confirm the feasibility of the formulation of hydrophilic and hydrophobic drug substances into a single-dosage preparation for pulmonary delivery using HBCD as an excipient. CFD analysis revealed that high inhalation performance was related to the true density and particle size of SDPs. The results on CFD simulations made a prediction about the particle behavior or deposition in pulmonary airways.
All 2018 2017 2016
All Journal Article (4 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 4 results, Acknowledgement Compliant: 2 results) Presentation (17 results) (of which Int'l Joint Research: 4 results, Invited: 1 results)
Journal of the Taiwan Institute of Chemical Engineers
Volume: 印刷中 Pages: 44-50
10.1016/j.jtice.2017.11.008
Journal of Pharmaceutical Innovation
Volume: 12 Issue: 3 Pages: 249-259
10.1007/s12247-017-9285-x
Journal of Pharmaceutical Sciences
Volume: 106 Issue: 1 Pages: 123-128
10.1016/j.xphs.2016.07.009
International Journal of Pharmaceutics
Volume: 517 Issue: 1-2 Pages: 8-18
10.1016/j.ijpharm.2016.11.060
