| Project/Area Number |
16K21533
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor therapeutics
Tumor biology
|
|---|
| Research Institution | Kawasaki Medical School |
|---|
Principal Investigator |
Kurose Koji 川崎医科大学, 医学部, 助教 (30551139)
|
|---|
| Research Collaborator |
Ohue Yoshihiro 川崎医科大学, 医学部, 講師 (70435014)
Nakayama Eiichi 川崎医科大学, 客員教授 (60180428)
Oka Mikio 川崎医科大学, 医学部, 教授 (40223995)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 肺癌微小環境 / 制御性T細胞 / Treg / PD-L1 / PD-1 / TIM-3 / 腫瘍浸潤リンパ球 / 非小細胞肺癌 / 肺がん |
|---|
| Outline of Final Research Achievements |
In this study, in order to clarify the presence or absence of inflammation of the tumor microenvironment and the involvement of tumor infiltrating regulatory T cells (Treg) in lung cancer, we examined the association of tumor infiltrating lymphocytes, Treg fraction, and inhibitory molecules PD-1, TIM-3 on T-cells with PD-L1 on tumor cells. In the high expression group of PD-L1, there were many tumor infiltrating lymphocytes, whereas there were also many activated Tregs, and high expression of PD-1 and TIM-3 on T cells was observed. Furthermore, Treg depletion using anti-CCR4 antibody resulted in an increase in the number of tumor infiltrating lymphocytes and an increase in the expression of PD-L1 on tumor cells. In the high expression group of PD-L1, Treg depletion and anti-PD-1 therapy may enhance the therapeutic effect.
|
