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Development of micelles mediated fluorescence analysis system

Research Project

Project/Area Number 16K21615
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Quantum beam science
Functional solid state chemistry
Research Institution一般財団法人総合科学研究機構(総合科学研究センター(総合科学研究室)及び中性子科学センター(研究開発

Principal Investigator

Kazuhiro Akutsu  一般財団法人総合科学研究機構(総合科学研究センター(総合科学研究室)及び中性子科学センター(研究開発, 中性子科学センター, 技師 (60637297)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords蛍光プローブ / XAFS / 中性子反射率 / ミセル / イオン分析 / ナノ空間 / EXAFS / 中性子 / ストロンチウム
Outline of Final Research Achievements

Because the micelles provide a unique hydrophobic nano-environment for stabilizing metal-organic complexes in aqueous solution, we focused on the unique properties of micelles to develop a new fluorescence analysis system. We synthesized a Sr(II) fluorescent probe, N-(2-hydroxy-3-(1H-benzimidazol-2-yl)-phenyl)-1-aza-18-crown-6-ether (BIC), and revealed that the stability constant of Sr(II)-BIC complex in sodium dodecyl sulfate (SDS) micellar solution was 10 times higher than that in aqueous solution. We also investigated the structure of Sr(II) complex in SDS micellar solution by combining use the extended X-ray absorption fine structure (EXAFS) and neutron reflectivity (NR) method. Based on the EXAFS and NR results, it is clear that Sr(II), BIC, and SDS formed a ternary complexes in SDS micellar solution, and at least, it is clear that the improvement of the stability constant in SDS micellar solution is attributed to the result of the formation of Sr(BIC)(SDS) complex.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2017 2016 Other

All Int'l Joint Research (1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] ANSTO(オーストラリア)

    • Related Report
      2017 Annual Research Report
  • [Presentation] Study of Micelle-Mediated Sr(II) Fluorescent Analysis System and It's Nano-Structure2017

    • Author(s)
      阿久津和宏
    • Organizer
      第27会日本MRS年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of nano-micelles mediated fluorescence analysis system for Sr(II) ion2016

    • Author(s)
      Kazuhiro Akutsu, Seiji Mori, Takayasu Hanashima
    • Organizer
      2016 EMN Summer Meeting
    • Place of Presentation
      Cancun, Mexico
    • Year and Date
      2016-06-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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