Basic study of a new helmet-type PET scanner enabling quantitative measurement of brain function in a short time

• Project/Area Number: 16K21637
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical Physics and Radiological Technology; Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Tashima Hideaki 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 計測・線量評価部, 主任研究員(定常) (70572907)
• Research Collaborator: Yamaya Taiga ; Yoshida Eiji ; Nishikido Fumihiko ; Abdella Ahmed M. ; Iwao Yuma ; Akamatsu Go ; Wakizaka Hidekatsu ; Obi Takashi
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: PET / 画像再構成 / 減弱補正 / 同時推定 / Time of Flight / 深層学習 / 脳機能イメージング / 認知症診断 / 脳PET / ヘルメットPET / 認知症 / アルツハイマー / 同時推定法 / 頭部専用PET / モンテカルロシミュレーション / 診断装置 / 高感度 / 低コスト

Outline of Final Research Achievements

Development of a high performance and compact dedicated brain PET scanner with low cost and minimal burden to patients is important for wide spread application of brain PET such as for early diagnosis of dementia. For PET studies, correction for attenuation effect inside a body is required for accurate diagnosis, requiring an image including morphological information such as of a CT image. However, it is difficult to integrate an additional device for the correction into a compact system. In this theme, therefore, methods enabling attenuation correction only from PET measurement data were proposed, and basic study was conducted. As a result, it was shown that simultaneous estimation method for a PET image and correction data combined with deep learning has potential for the quantitative measurement for a brain dedicated PET system with high timing resolution.

Academic Significance and Societal Importance of the Research Achievements

時間情報を用いたＰＥＴは、測定対象が大きいほど効果が高いため、主に全身用装置において研究開発が進められてきたが、ＴＯＦヘルメット型ＰＥＴ装置のような頭部専用かつ高時間分解能装置を対象とした点に新規性と学術的意義がある。
高齢化社会において認知症対策は喫緊の課題であり、早期診断によって発症を遅らせたり、抑えたりできる可能性がある。本課題の成果により、低コストな普及型の頭部用ＰＥＴ装置開発が加速され、多くの人が認知症の早期診断の恩恵を受けられるようになると期待できる。

Research Products

• [Journal Article] First prototyping of a dedicated PET system with the hemisphere detector arrangement (2019)
  • Author(s): Tashima Hideaki、Yoshida Eiji、Iwao Yuma、Wakizaka Hidekatsu、Maeda Takamasa、Seki Chie、Kimura Yasuyuki、Takado Yuhei、Higuchi Makoto、Suhara Tetsuya、Yamashita Taichi、Yamaya Taiga
  • Journal Title: Physics in Medicine & Biology Volume: 64 Issue: 6 Pages: 065004-065004
  • DOI: 10.1088/1361-6560/ab012c
  • Peer Reviewed / Open Access
• [Journal Article] Simulation study comparing the helmet-chin PET with a cylindrical PET of the same number of detectors (2017)
  • Author(s): A. M. Ahmed, H. Tashima, E. Yoshida, F. Nishikido, T. Yamaya
  • Journal Title: Physics in Medicine and Biology Volume: 62 Issue: 11 Pages: 4541-4550
  • DOI: 10.1088/1361-6560/aa685c
  • Peer Reviewed
• [Journal Article] Investigation of the optimal detector arrangement for the helmet-chin PET: A simulation study (2017)
  • Author(s): A. M. Ahmed, H. Tashima, E. Yoshida, T. Yamaya
  • Journal Title: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment Volume: 858 Pages: 96-100
  • DOI: 10.1016/j.nima.2017.03.044
  • Peer Reviewed
• [Journal Article] Proposed helmet PET geometries with add-on detectors for high sensitivity brain imaging (2016)
  • Author(s): H. Tashima and T Yamaya
  • Journal Title: Physics in Medicine and Biology Volume: 61 Issue: 19 Pages: 7205-7220
  • DOI: 10.1088/0031-9155/61/19/7205
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Basic Components and Principles of PET (3): Image Reconstruction and Data Corrections Necessary for PET Imaging (2016)
  • Author(s): 田島英朗
  • Journal Title: Medical Imaging Technology Volume: 34 Issue: 5 Pages: 287-291
  • DOI: 10.11409/mit.34.287
  • NAID: 130005171495
  • ISSN: 0288-450X, 2185-3193
• [Presentation] 頭部専用PETにおける放射能・減弱補正係数同時推定法の深層学習を用いた精度向上手法の検討 (2019)
  • Author(s): 呉 博文、 田島 英朗、 山谷 泰賀、 小尾 高史
  • Organizer: 第38回日本医用画像工学会大会
• [Presentation] Development of an Imaging Simulation Framework Enabling Modelling of PET Scanners with Arbitrary Detector Arrangement (2018)
  • Author(s): Hideaki Tashima, Eiji Yoshida, Go Akamatsu, Taiga Yamaya
  • Organizer: 第115回日本医学物理学会学術大会
• [Presentation] Normalization for brain-dedicated PET with the hemispherical detector arrangement (2018)
  • Author(s): Hideaki Tashima, Go Akamatsu, Yuma Iwao, Hidekatsu Wakizaka, Eiji Yoshida, Taichi Yamashita, Taiga Yamaya
  • Organizer: IEEE NSS&MIC 2018
  • Int'l Joint Research
• [Presentation] A new hollow-dome phantom for normalization of the helmet-neck PET (2018)
  • Author(s): Hideaki Tashima, Go Akamatsu, Yuma Iwao, Hidekatsu Wakizaka, Eiji Yoshida, Taichi Yamashita, Taiga Yamaya
  • Organizer: SNMMI 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] ヘルメットPET装置の開発：追加検出器位置の最適化 (2017)
  • Author(s): 田島英朗, 吉田英治, 岩男悠真, 脇坂秀克, 山下大地, 田沢周作, 山谷泰賀
  • Organizer: 第64回応用物理学会春季学術講演会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2017-03-14
• [Presentation] 小型頭部専用TOF-PETにおける放射能濃度分布と吸収補正の同時推定法の評価 (2017)
  • Author(s): 田中 理紗子, 小尾 高史, 田島 英朗, Ahmed Abdella Mohammednur, 山谷 泰賀
  • Organizer: JAMITフロンティア, 電子情報通信学会医用画像研究会
• [Presentation] Development of the helmet-neck PET prototype: comparison with the helmet-chin PET (2017)
  • Author(s): H. Tashima, E. Yoshida, Y. Iwao, H. Wakizaka, T. Maeda, Y. Takado, C. Seki, M. Higuchi, T. Suhara, T. Yamashita, T. Yamaya
  • Organizer: 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Int'l Joint Research
• [Presentation] First healthy volunteer study of the helmet-neck PET prototype (2017)
  • Author(s): Hideaki Tashima, Eiji Yoshida, Yuma Iwao, Hidekatsu Wakizaka, Takamasa Maeda, Yuhei Takado, Chie Seki, Makoto Higuchi, Tetsuya Suhara, Taichi Yamashita, Taiga Yamaya
  • Organizer: The 12th Asia Oceania Congress of Nuclear Medicine and Biology
  • Int'l Joint Research
• [Presentation] Add-on detector position for the second helmet PET prototype: chin vs. neck (2017)
  • Author(s): Hideaki Tashima, Eiji Yoshida, Yuma Iwao, Hidekatsu Wakizaka, Takamasa Maeda, Yuhei Takado, Chie Seki, Tetsuya Suhara, Taichi Yamashita, Shusaku Tazawa, Taiga Yamaya
  • Organizer: SNMMI 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] Helmet-Neck PET試作機による健常者ボランティア試験 (2017)
  • Author(s): 田島英朗, 吉田英治, 岩男悠真, 脇坂秀克, 前田貴雅, 高堂裕平, 関千江, 樋口真人, 須原哲也, 山下大地, 山谷泰賀
  • Organizer: 第78回応用物理学会秋季学術講演会
  • Int'l Joint Research
• [Presentation] 改良型ヘルメットPET装置の試作と健常者ボランティア試験 (2017)
  • Author(s): 田島英朗, 吉田英治, 岩男悠真, 脇坂秀克, 前田貴雅, 高堂裕平, 関千江, 樋口真人, 山下大地, 山谷泰賀
  • Organizer: 第36回日本医用画像工学会大会
  • Int'l Joint Research
• [Presentation] Joint estimation of activity and attenuation for a compact brain TOF-PET system : a simulation study (2017)
  • Author(s): Risako Tanaka, Hideaki Tashima, Abdella M. Amed, Taiga Yamaya, Takashi Obi
  • Organizer: 第113回日本医学物理学会学術大会
• [Presentation] First Clinical Test of the Helmet-Chin PET Prototype (2016)
  • Author(s): Hideaki Tashima, Eiji Yoshida, Yuma Iwao, Hidekatsu Wakizaka, Shusaku Tazawa, Chie Seki, Yasuyuki Kimura, Tetsuya Suhara, Taiga Yamaya
  • Organizer: IEEE NSS&MIC 2016
  • Place of Presentation: Strasbourg, France
  • Year and Date: 2016-10-29
  • Int'l Joint Research
• [Presentation] Detector Size and Geometry Optimization for the Helmet-Chin PET (2016)
  • Author(s): Abdella, M. Ahmed, Hideaki Tashima, Eiji Yoshida, Taiga Yamaya
  • Organizer: IEEE NSS&MIC 2016
  • Place of Presentation: Strasbourg, France
  • Year and Date: 2016-10-29
  • Int'l Joint Research
• [Presentation] ヘルメット型PETにおける画像再構成法の開発 (2016)
  • Author(s): 田島英朗, 吉田英治, 岩男悠真, 山谷泰賀
  • Organizer: 第35回日本医用画像工学会学術大会
  • Place of Presentation: 千葉大学西千葉キャンパスけやき会館（千葉県千葉市）
  • Year and Date: 2016-07-21
• [Presentation] Initial clinical test of the first Helmet-Chin PET prototype for highly sensitive brain imaging (2016)
  • Author(s): H. Tashima, E. Yoshida, F. Nishikido, H. Wakizaka, Y. Iwao, A. M. Ahmed, A. Mohammadi, Y. Kimura, T. Suhara, Y. Fujibayashi, S. Tazawa, T. Yamaya
  • Organizer: SNMMI Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-06-09
  • Int'l Joint Research
• [Presentation] Development of attenuation correction method for helmet-chin PET prototype using CT images (2016)
  • Author(s): Yuma Iwao, Hideaki Tashima , Eiji Yoshida, Hiromi Sano, Yasuyuki Kimura, Taiga Yamaya
  • Organizer: 第113回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-04-14
• [Remarks] 次世代PET開発研究会報告書
  • URL: https://www.nirs.qst.go.jp/usr/medical-imaging/ja/study/main.html
• [Remarks] 次世代PET開発研究会報告書
  • URL: http://www.nirs.qst.go.jp/usr/medical-imaging/ja/study/main.html
• [Patent(Industrial Property Rights)] ヘルメット型PET装置 (2017)
  • Inventor(s): 田島英朗, 山谷泰賀
  • Industrial Property Rights Holder: 国立研究開発法人量子科学技術研究開発機構
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Acquisition Date: 2017
• [Patent(Industrial Property Rights)] ヘルメット型PET装置 (2017)
  • Inventor(s): 田島英朗, 山谷泰賀
  • Industrial Property Rights Holder: 田島英朗, 山谷泰賀
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-058848
  • Filing Date: 2017-03-24