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A study on SLC15A3 as new regulator of molecular environment in lysosome and inflammation

Research Project

Project/Area Number 16K21655
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Experimental pathology
Research InstitutionNational Center for Global Health and Medicine

Principal Investigator

Ohshima Daisuke  国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (70769653)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsアミノ酸トランスポーター / 炎症 / 免疫 / 炎症応答 / 生体膜 / トランスポーター / 能動輸送
Outline of Final Research Achievements

A lysosome-resident, amino acid/oligopeptide transporter, SLC15A4, plays a critical role of the inflammatory response and SLC15A4 is possible therapeutic target in pathogenesis of inflammatory diseases. One of the SLC15 family members, SLC15A3 has highly conserved regions of SLC15A4, but its molecular functions have not been elucidated. SLC15A3 deficient mice were developed, but they showed no significant phenotypes such as cell proliferation and differentiation in the thymus, spleen, and lymph node. Several disease models are developed using SLC15A3 deficient mice, and they will be continuously analyzed to find a novel role of lysosomal transporter.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells2017

    • Author(s)
      Kobayashi Toshihiko、Tsutsui Hidemitsu、Shimabukuro-Demoto Shiho、Yoshida-Sugitani Reiko、Karyu Hitomi、Furuyama-Tanaka Kaori、Ohshima Daisuke、Kato Norihiro、Okamura Tadashi、Toyama-Sorimachi Noriko
    • Journal Title

      International Immunology

      Volume: 29 Issue: 12 Pages: 551

    • DOI

      10.1093/intimm/dxx063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Regulation of innate immune responses by oligopeptide transporter SLC15A3.2016

    • Author(s)
      OHSHIMA Daisuke, KOBAYASHI Toshihiko, SORIMACHI-TOYAMA Noriko
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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