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Circadian rhythm of brain and whole body coordination:arterial spin labeling fMRI study

Research Project

Project/Area Number 16K21657
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied anthropology
Basic / Social brain science
Research InstitutionKyushu University (2017-2018)
National Center of Neurology and Psychiatry (2016)

Principal Investigator

Motomura Yuki  九州大学, 芸術工学研究院, 助教 (50645273)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords潅流スピンラベリング / 機能的MRI / 生体リズム / 睡眠 / 一次視覚野 / 局所血液潅流量 / 前帯状皮質 / 島皮質 / 日周嗜好性 / 過覚醒 / fMRI / 脳とリズム / 生理人類学 / 生理値同時測定
Outline of Final Research Achievements

In this study, we aimed to investigate the relationship between human sleep, life rhythm and brain activity using perfusion spin labeling (ASL). The measurement of resting ASL image and the measurement of sleep and life rhythm by actigraph were carried out, and the relationship between the two was examined. As a result, rCBF of lingual gyrus showed a significant positive correlation with the standard deviation of the sleep midpoint time associated with the instability of the biological rhythm mechanism. It was suggested that the relationship between disturbance of biological rhythm and visual area activity at resting state.

Academic Significance and Societal Importance of the Research Achievements

精神機能に多大な影響を及ぼすにもかかわらず、生体リズム機構と実際の脳活動との関連についてMRIを用いて検討した研究は少なく、その詳細は明らかにされていなかった。本研究の成果は生体リズム機構の影響を受ける睡眠覚醒リズムの乱れが安静時の脳機能に影響を与えることを示しており、生活リズムの乱れやすい交代勤務労働者のパフォーマンス改善や健康増進に有用な知見となることが考えられるほか、睡眠覚醒リズム障害患者の病態解明に寄与する可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (22 results)

All 2019 2018 2017 2016

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] 機械学習を用いた動画解析による生体情報の自動追跡技術:瞼裂幅計測に用いた一例2019

    • Author(s)
      西村英伍、元村祐貴、勝沼るり、吉村道孝、三島和夫、尾方義人
    • Journal Title

      日本生理人類学会誌

      Volume: 24 Pages: 35-45

    • NAID

      130007632629

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attentional bias modification alters intrinsic functional network of attentional control: A randomized controlled trial.2018

    • Author(s)
      Hakamata Y, Mizukami S, Komi S, Sato E, Moriguchi Y, Motomura Y, Maruo K, Izawa S, Kim Y, Hanakawa T, Inoue Y, Tagaya H.
    • Journal Title

      Journal of Affective Disorders

      Volume: 238 Pages: 472-481

    • DOI

      10.1016/j.jad.2018.06.018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BRAIN AND ADAPTATION / ACCLIMATISATION: BRAIN RESEARCH IN PHYSIOLOGICAL ANTHROPOLOGY2018

    • Author(s)
      元村 祐貴
    • Journal Title

      Japanese Journal of Physiological Anthropology

      Volume: 23 Issue: 4 Pages: 185-187

    • DOI

      10.20718/jjpa.23.4_185

    • NAID

      130007580257

    • ISSN
      1342-3215, 2432-0986
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced Nogo-P3 amplitudes of mothers compared with non-mother women during an emotional Go/Nogo task2018

    • Author(s)
      Hayashi Sayuri、Wada Hiroko、Kim Sung-Phil、Motomura Yuki、Higuchi Shigekazu、Kim Yeon-Kyu
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 37 Issue: 1 Pages: 8-8

    • DOI

      10.1186/s40101-018-0167-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 睡眠負債による脳機能への影響 (特集 睡眠負債)2018

    • Author(s)
      元村祐貴
    • Journal Title

      睡眠医療 : 睡眠医学・医療専門誌

      Volume: 12 Pages: 337-343

    • NAID

      40021695207

    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Unrecognized Sleep Loss Accumulated in Daily Life Can Promote Brain Hyperreactivity to Food Cue.2017

    • Author(s)
      Katsunuma R, Oba K, Kitamura S, Motomura Y, Terasawa Y, Nakazaki K, Hida A, Moriguchi Y, Mishima K
    • Journal Title

      Sleep

      Volume: 40(10)

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two Days' Sleep Debt Causes Mood Decline During Resting State Via Diminished Amygdala-Prefrontal Connectivity.2017

    • Author(s)
      Motomura Y, Katsunuma R, Yoshimura M, Mishima K
    • Journal Title

      Sleep

      Volume: 40(10)

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recovery from Unrecognized Sleep Loss Accumulated in Daily Life Improved Mood Regulation via Prefrontal Suppression of Amygdala Activity.2017

    • Author(s)
      Motomura Y, Kitamura S, Nakazaki K, Oba K, Katsunuma R, Terasawa Y, Hida A, Moriguchi Y, Mishima K
    • Journal Title

      Front Neurol

      Volume: 8:306 Pages: 306-306

    • DOI

      10.3389/fneur.2017.00306

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders2017

    • Author(s)
      A Hida, Y Ohsawa, S Kitamura, K Nakazaki, N Ayabe, Y Motomura, K Matsui, M Kobayashi, A Usui, Y Inoue, H Kusanagi, Y Kamei, K Mishima
    • Journal Title

      Transl Psychiatry

      Volume: 7 Issue: 4 Pages: e1106-e1106

    • DOI

      10.1038/tp.2017.75

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 睡眠・概日リズム機構が気分調節に及ぼす影響とその神経基盤.2016

    • Author(s)
      元村祐貴
    • Journal Title

      時間生物学

      Volume: 22,1, Pages: 12-18

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 睡眠習慣と安静時脳活動の関連:ASL-fMRIを用いた検討2018

    • Author(s)
      元村祐貴 勝沼るり 北村真吾 綾部直子 吉村道孝 肥田昌子 三島和夫
    • Organizer
      日本生理人類学会第76回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 無意識的な情動伝達経路の役割:眠気と閾下呈示された恐怖表情刺激に対する扁桃体活動の関連2018

    • Author(s)
      元村祐貴 北村真吾 大場健太郎 寺澤悠理 榎本みのり 肥田昌子 守口善也 樋口重和 三島和夫
    • Organizer
      第11回日本人間行動進化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 精神運動ヴィジランス課題時の脳活動2018

    • Author(s)
      元村 祐貴, 北村 真吾, 中崎 恭子, 大場 健太郎, 勝沼 るり, 寺澤 悠理, 肥田 昌子,守口 善也, 三島 和夫
    • Organizer
      日本生理人類学会第77回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Recovery from unrecognized sleep debt accumulated in daily life improved mood regulation: arterial spin labeling fMRI study2018

    • Author(s)
      Yuki Motomura, Shingo Kitamura, Kyoko Nakazaki, Kentaro Oba, Ruri Katsunuma, Yuri Terasawa, Akiko Hida, Yoshiya Moriguchi, Kazuo Mishima
    • Organizer
      ASRS2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳と適応2018

    • Author(s)
      元村祐貴
    • Organizer
      日本生理人類学会第76回大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 視床を中心とする脳内ネットワークと主観的眠気の関連:安静時fMRIによる検討2017

    • Author(s)
      元村祐貴, 北村真吾, 中崎恭子, 大場健太郎, 勝沼るり, 寺澤悠里, 肥田昌子, 守口善也, 三島和夫
    • Organizer
      日本生理人類学会第76回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 睡眠負債時における顔表情認知と情動伝染2017

    • Author(s)
      元村祐貴, 勝沼るり, 吉村道孝, 三島和夫
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 慢性不眠症患者の情動機能:fMRI研究2017

    • Author(s)
      元村祐貴, 勝沼るり, 綾部直子, 大場健太郎, 寺澤悠里, 北村真吾, 肥田昌子, 守口善也, 亀井雄一, 三島和夫
    • Organizer
      不眠研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] The role of sleep in emotion and mood regulation.2016

    • Author(s)
      Motomura Y
    • Organizer
      UNIST-JPA Joint Symposium 2016 on Anthropological and Physiological Research on Humans Living in Modern Society of East Asia
    • Place of Presentation
      Ulsan, Korea
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Two days sleep debt causes mood decline during resting state viadiminished amygdala-prefrontal connectivity2016

    • Author(s)
      Motomura Y, Katsunuma R, Itasaka M, Yoshimura M, Mishima K
    • Organizer
      ESRS2016
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 睡眠相後退型、フリーラン型の抹消時計リズム周期2016

    • Author(s)
      肥田昌子, 北村真吾, 中﨑恭子, 綾部直子, 元村祐貴, 加藤美恵, 松井健太郎, 小林美奈, 碓氷章, 井上雄一, 草薙宏明, 亀井雄一, 三島和夫
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 睡眠負債時における安静時気分の低下とその神経基盤:fMRI研究2016

    • Author(s)
      元村祐貴, 勝沼るり, 板坂典朗, 吉村道孝, 三島和夫
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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