Automated evaluation system of white matter hyper intensity and computer aided diagnosis for dementia using MRI

Research Project

Project/Area Number	16K21660
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science Medical systems
Research Institution	Tohoku University (2017) National Center of Neurology and Psychiatry (2016)
Principal Investigator	Norihide Maikusa 東北大学, 東北メディカル・メガバンク機構, 助教 (80631069)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	Alzheimer's disease / MRI / 脳画像解析 / アルツハイマー病 / a / ＭＲＩ
Outline of Final Research Achievements	We developed an automatic computer aided diagnostic method of Alzheimer's disease using longitudinal T1-MRI. This method used not only for atrophy of gray matter but also White matter hypo-intensity on T1 images. To asses proposed method using data of Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI).We used Support vector machine for Alzheimer group and healthy group using proposed method.As a result, it showed that it can be identified with a sensitivity of 87.9% and a specificity of 80.0%.