| Project/Area Number |
16K21670
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
Collagenous pathology/Allergology
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Shoda Tetsuo 国立研究開発法人国立成育医療研究センター, 生体防御系内科部, 医師研究員 (00724311)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 好酸球性消化管疾患 / 腸内細菌叢 / メタボローム / 腸内細菌 / アレルギー・ぜんそく |
|---|
| Outline of Final Research Achievements |
Microbes may increase susceptibility to eosinophilic gastrointestinal disorders (EGID) by producing bioactive metabolites that affect immune activity and epithelial function. To uncover disease-associated microbial and metabolomics profile in pediatric EGID by next-generation sequencing analysis, a case-control study (EGID vs control, n=5 vs 10) was conducted. Several analyses, including principal coordinate analysis, cluster analysis and integrated analysis of both microbiome and metabolome, did not show significant differences between EGID and control. In this case-control study, a disease-associated microbial and metabolomics profile in pediatric EGID was not found.
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