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Analysis of synaptic connectivity regulated by Sparcl1/Hevin variants during brain development(Fostering Joint International Research)

Research Project

Project/Area Number 16KK0158
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Cell biology
Research InstitutionUniversity of Tsukuba

Principal Investigator

TSURUTA Fuminori  筑波大学, 生命環境系, 助教 (30571450)

Project Period (FY) 2017 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
KeywordsSparcl1/Hevin / USP15 / neurons / astrocytes / microglia / Sparcl1 / Astrocyte / Microglia / RNA splicing / ミクログリア / アストロサイト
Outline of Final Research Achievements

RNA metabolism is regulated in timing- and region-specific manners. Recently, it has been reported that a defect in this process leads to developmental disorders. So far, we have found that loss of USP15 causes an abnormal spliceosomal function, leading to global splicing errors. In this study, we have focused on the Sparcl1 mutant produced by USP15 deficient brain and analyzed a link between Sparcl1 abnormality and ER stress. Since USP15 and Sparcl1 act as responsible genes for autism, we expect that our data provide a clue for understanding that underlie not only RNA metabolism but also developmental disorders.

Academic Significance and Societal Importance of the Research Achievements

本課題で検証を行ったUSP15とSparcl1は、双方とも自閉症の責任遺伝子として報告されている。その一方で、これら遺伝子の異常がなぜ自閉症につながるのか明らかではなかった。本研究課題では、これら遺伝子の異常が、小胞体ストレスの誘導につながることを新たに発見した。小胞体ストレスと発達障害の関連はほとんど解析が進んでいないことから、本研究成果は、発達障害研究に対する新しい視点を提供できるのではないかと期待している。

Report

(2 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (5 results)

All 2019 2018

All Int'l Joint Research (2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] スタンフォード大学医学部(米国)2019

    • Year and Date
      2019-02-01
    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] デューク大学医学部(米国)2018

    • Year and Date
      2018-04-14
    • Related Report
      2019 Annual Research Report
  • [Presentation] Regulation of RNA splicing associated with environmental stimulation in the postnatal brain.2019

    • Author(s)
      Tsuruta F
    • Organizer
      Society for Neuroscience
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microglia dynamics regulated by neuronal micronuclei during brain development2019

    • Author(s)
      Tsuruta F
    • Organizer
      Bilateral Symposium on Life Science, University of Tsukuba vs National Taiwan University
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of RNA splicing associated with environmental stimulation in the postnatal brain2019

    • Author(s)
      鶴田文憲
    • Organizer
      日本神経科学会
    • Related Report
      2019 Annual Research Report

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Published: 2017-03-15   Modified: 2021-02-19  

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