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Morphological analysis of mitochondria during mitophagy(Fostering Joint International Research)

Research Project

Project/Area Number 16KK0162
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Functional biochemistry
Research InstitutionNiigata University

Principal Investigator

Yamashita Shun-ichi  新潟大学, 医歯学系, 助教 (30529095)

Project Period (FY) 2017 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Keywordsミトコンドリア / マイトファジー / オートファジー
Outline of Final Research Achievements

Mitochondrial morphology is regulated by their fusion and division, that is important for maintaining mitochondrial function. In addition, mitochondrial division is also required for mitophagy. Drp1 which is main player of mitochondrial division have been believed to be required for mitochondrial division during mitophagy, so far. However, I have reported that mitophagy is normally detected in the absence of Drp1. In this context, small mitochondrion destined for degradation is divided simultaneously with closing of the isolation membrane, but independently of Drp1. Aiming to clarify the molecular mechanism of the novel mitochondrial division, I focused on mitophagy receptors and identified two mitophagy receptors as essential factors for hypoxia- and iron depletion-induced mitophagy. During mitophagy, they gradually accumulated in between the isolation membrane and mitochondria.

Academic Significance and Societal Importance of the Research Achievements

ミトコンドリアの機能不全は多くの疾患の原因になり、その機能維持は疾患治療や予防に重要である。申請者はミトコンドリアの機能維持機構の一つとして考えられる不良ミトコンドリアの分解除去機構であるマイトファジーにおいて、不良なミトコンドリアのみがどのようにして正常なミトコンドリアから切り取られるのかについて研究を行った。このミトコンドリア分裂機構は、既存のミトコンドリア分裂機構とは異なる分子機構によるもので、それらにかかわると考えられる因子の同定に成功した。このことは未知の分子機構解明に大きく寄与するものであり学術的な意義が大きい。

Report

(2 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (6 results)

All 2020 2019 2018

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (1 results) (of which Invited: 1 results) Book (1 results)

  • [Int'l Joint Research] カリフォルニア工科大学(米国)2018

    • Year and Date
      2018-10-15
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1.2020

    • Author(s)
      Igarashi R, Yamashita SI, Yamashita T, Inoue K, Fukuda T, Fukuchi T, Kanki T.
    • Journal Title

      Sci Rep.

      Volume: 10(1) Issue: 1 Pages: 1465-1465

    • DOI

      10.1038/s41598-020-58315-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FKBP8 LIRL‐dependent mitochondrial fragmentation facilitates mitophagy under stress conditions2020

    • Author(s)
      Yoo Seung‐Min、Yamashita Shun‐ichi、Kim Hyunjoo、Na DoHyeong、Lee Haneul、Kim Seo Jin、Cho Dong‐Hyung、Kanki Tomotake、Jung Yong‐Keun
    • Journal Title

      The FASEB Journal

      Volume: 34 Issue: 2 Pages: 2944-2957

    • DOI

      10.1096/fj.201901735r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glaucoma-Associated Mutations in the Optineurin Gene Have Limited Impact on Parkin-Dependent Mitophagy.2019

    • Author(s)
      Chernyshova K, Inoue K, Yamashita SI, Fukuchi T, Kanki T.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 60(10) Issue: 10 Pages: 3625-3635

    • DOI

      10.1167/iovs.19-27184

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ミトコンドリア分解におけるマイトファジーレセプタータンパク質の役割2019

    • Author(s)
      山下俊一、David Chan、神吉智丈
    • Organizer
      第42回日本分子生物学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Book] ミトコンドリアと疾患・老化2019

    • Author(s)
      井上敬一、山下俊一、神吉智丈
    • Total Pages
      221
    • Publisher
      羊土社
    • ISBN
      9784758103800
    • Related Report
      2019 Annual Research Report

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Published: 2017-03-15   Modified: 2021-02-19  

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