| Outline of Final Research Achievements |
In diseases of the elderly, the brain physiology is presumed to be reflecting to the cause of acquired diseases. We conducted an international collaborative study with Kuopio University Hospital, which included clinical data and cortical biopsy tissues of patients with cognitive impairment, and analyzed the expression certain markers and parameters and their influence on disease using data from brain metabolism, pathological tissues, and cerebrospinal fluid (CSF). The results showed that protein tyrosine phosphatase receptor type Q was strongly expressed in choroid plexus epithelial cells and ependymal cells of the ventricular walls, and was abundantly contained in the CSF of adults with chronic hydrocephalus showing ventricular enlargement. In addition, leucine-rich α2 glycoprotein in CSF was increased in patients with idiopathic normal pressure hydrocephalus, independently of concomitant Alzheimer's disease specific pathological changes.
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