| Outline of Final Research Achievements |
The purpose of this study was to evaluate the current status of the development of devices using three-dimensional (3D) culture and the quality, efficacy, and safety of cell medicine, cellular products, and pharmaceuticals. The outline of the project is as follows: 1) Cryopreservation and quality evaluation of differentiated neural-like cells, 2) Development of microfluidic devices and current status of toxicity evaluation systems, 3) Quality, efficacy, and safety of cells and drugs in reproductive medicine, 4) Development of spheroid culture devices and toxicity evaluation of nano-medicine, 5) Development of culture devices using MEMS technology and creation of skeletal muscle tissue. The toxicity of nanopharmaceuticals (magnetic nanoparticles) was evaluated using each of the 3D culture devices, and the results showed good reproducibility and in vivo-like trends.
|
