Establishment of an intercontinental cohort database for ABCA4-associated retinal disorder in global eye genetic consortium, including 7 countries from Europe, America, and Asia(Fostering Joint International Research)

• Project/Area Number: 16KK0193
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: 独立行政法人国立病院機構(東京医療センター臨床研究センター)
• Principal Investigator: Fujinami Kaoru 独立行政法人国立病院機構(東京医療センター臨床研究センター), 視覚研究部 視覚生理学研究室, 室長 (60646206)
• Research Collaborator: Michaelides Michel UCL Institute of Ophthalmology, Genetics, Professor ; TSUNODA Kazushige ; IWATA Takeshi ; MIYAKE Yozo ; WEBSTER Andrew ; ARNO Gavin ; PONTIKOS Nikolas ; SERGONIOTIS Panagiotis ; SCHOLL Hendrik ; STRAUSS Rupert ; WEST Siela ; KAHN Kamron ; BERNSTEIN Paul ; BIRCH David ; BOMOTTI Samantha ; CIDECYAN Artur ; TRABOUSLI Elias ; ZRENNER Eberhart ; SERGEEV Yuri ; ALLIKMETS Rando ; SUI Ruifang ; LI Shiying ; LEI Bo ; ZHANG Qingjiong ; YANG Lizhu ; FUJINAMI Yu (YOKOKAWA Yu) ; LIU Xiao ; WOO Se joon ; JOO Kwangik
• Project Period (FY): 2017 – 2018
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
• Keywords: 眼遺伝学 / 遺伝学

Outline of Final Research Achievements

The purpose of this study is to establish a global cohort of ABCA4-associated retinal disorders, a leading cause of blindness in the developed nations, utilizing an international database under global collaboration. Global consortium includes 13 institutes from 7 countries; National Tokyo Medical Center from Japan, 6 institutes from USA, one from UK, one from Germany, two from China, one from Korea. Based on the standardized clinical diagnostic criteria, 916 subjects have been registered in total; Japan (278), UK (328), USA (150), France (61), Germany (49), China (42), Korea (8). Statistically significant difference of allele frequency of prevalent variants was revealed between ethnicity, which promotes to develop the clinical therapeutic trials in each continent.

Academic Significance and Societal Importance of the Research Achievements

本研究で構築された900例を超えるABCA4関連網膜症コホートは遺伝性希少疾患として世界最大級のものとなった。民族内訳はヨーロッパ人375例、アジア人365例、アフリカ人30例、その他146例であった。また、各民族に対する高頻度病的バリアントが同定され、大陸・民族・地域単位での病態理解、詳細な遺伝子型表現型相関・関連が構築された。本研究において、大陸・民族・地域単位での病態理解が進んだ事で、同疾患の治療導入が文字通り世界規模で推進された。今後は、さらなる症例集積を継続する事で、バリアントの世界分布・起源解析が可能となり、失明原因としての同疾患の人類規模での発症メカニズムの解明が期待される。

Research Products

• [Int'l Joint Research] UCL Institute of Ophthalmology(英国) (2017)
• [Journal Article] Clinical findings of end-stage retinitis pigmentosa with a homozygous PDE6A variant (p.R653X) (2019)
  • Author(s): Mizobuchi Kei、Katagiri Satoshi、Hayashi Takaaki、Yoshitake Kazutoshi、Fujinami Kaoru、Kuniyoshi Kazuki、Mishima Reimi、Tsunoda Kazushige、Iwata Takeshi、Nakano Tadashi
  • Journal Title: American Journal of Ophthalmology Case Reports Volume: 13 Pages: 110-115
  • DOI: 10.1016/j.ajoc.2018.12.019
  • Peer Reviewed / Open Access
• [Journal Article] High-Resolution Retinal Imaging Reveals Preserved Cone Photoreceptor Density and Choroidal Thickness in Female Carriers of Choroideremia. (2019)
  • Author(s): Suzuki K, Gocho K, Akeo K, Kikuchi S, Kubota D, Katagiri S, Fujinami K, Tsunoda K, Iwata T, Yamaki K, Igarashi T, Nakano T, Takahashi H, Hayashi T, Kameya S.
  • Journal Title: Ophthalmic Surg Lasers Imaging Retina. Volume: 50(2) Issue: 2 Pages: 76-85
  • DOI: 10.3928/23258160-20190129-03
  • Peer Reviewed / Open Access
• [Journal Article] Cross-Sectional and Longitudinal Assessment of the Ellipsoid Zone in Childhood-Onset Stargardt Disease (2019)
  • Author(s): Tanna Preena、Georgiou Michalis、Strauss Rupert W.、Ali Naser、Kumaran Neruban、Kalitzeos Angelos、Fujinami Kaoru、Michaelides Michel
  • Journal Title: Translational Vision Science & Technology Volume: 8 Issue: 2 Pages: 1-1
  • DOI: 10.1167/tvst.8.2.1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Three cases of acute-onset bilateral photophobia (2019)
  • Author(s): Ueno Shinji、Inooka Daiki、Meinert Monika、Ito Yasuki、Tsunoda Kazushige、Fujinami Kaoru、Iwata Takeshi、Ohde Hisao、Terasaki Hiroko
  • Journal Title: Japanese Journal of Ophthalmology Volume: 63 Issue: 2 Pages: 172-180
  • DOI: 10.1007/s10384-018-00649-0
  • Peer Reviewed / Open Access
• [Journal Article] Novel mutations in the RS1 gene in Japanese patients with X-linked congenital retinoschisis (2019)
  • Author(s): Kondo Hiroyuki、Oku Kazuma、Katagiri Satoshi、Hayashi Takaaki、Nakano Tadashi、et al.
  • Journal Title: Human Genome Variation Volume: 6 Issue: 1 Pages: 3-3
  • DOI: 10.1038/s41439-018-0034-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prediction of Causative Genes in Inherited Retinal Disorders from Spectral-Domain Optical Coherence Tomography Utilizing Deep Learning Techniques (2019)
  • Author(s): Fujinami-Yokokawa Yu、Pontikos Nikolas、Yang Lizhu、Tsunoda Kazushige、Yoshitake Kazutoshi、Iwata Takeshi、Miyata Hiroaki、Fujinami Kaoru、Japan Eye Genetics Consortium on behalf of
  • Journal Title: Journal of Ophthalmology Volume: 2019 Pages: 1-7
  • DOI: 10.1155/2019/1691064
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake disease); EAOMD Report No.1 (2019)
  • Author(s): Fujinami Kaoru、Yang Lizhu、Joo Kwangsic、Tsunoda Kazushige、Kameya Shuhei、Hanazono Gen、Fujinami-Yokokawa Yu、Arno Gavin、Kondo Mineo、Nakamura Natsuko、Kurihara Toshihide、Tsubota Kazuo、Zou Xuan、Li Hui、Park Kyu Hyung、Iwata Takeshi、Miyake Yozo、Woo Se Joon、Sui Ruifang
  • Journal Title: Ophthalmology Volume: - Issue: 10 Pages: 1432-1444
  • DOI: 10.1016/j.ophtha.2019.04.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early Patterns of Macular Degeneration in ABCA4-Associated Retinopathy. (2018)
  • Author(s): Khan KN, Kasilian M, Mahroo OAR, Tanna P, Kalitzeos A, Robson AG, Tsunoda K, Iwata T, Moore AT, Fujinami K, Michaelides M.
  • Journal Title: Ophthalmology Volume: 125(5) Issue: 5 Pages: 735-746
  • DOI: 10.1016/j.ophtha.2017.11.020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visual Acuity Change Over 24 Months and Its Association With Foveal Phenotype and Genotype in Individuals With Stargardt Disease (2018)
  • Author(s): Kong Xiangrong、Fujinami Kaoru、Strauss Rupert W.、Munoz Beatriz、West Sheila K.、Cideciyan Artur V.、Michaelides Michel、Ahmed Mohamed、Ervin Ann-Margret、Sch?nbach Etienne、Cheetham Janet K.、Scholl Hendrik P. N.、for the ProgStar Study Group
  • Journal Title: JAMA Ophthalmology Volume: 136 Issue: 8 Pages: 920-920
  • DOI: 10.1001/jamaophthalmol.2018.2198
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Retinal findings in a patient with mutations in ABCC6 and ABCA4 (2018)
  • Author(s): Mahroo Omar A.、Fujinami Kaoru、Moore Anthony T.、Webster Andrew R.
  • Journal Title: Eye Volume: 32 Issue: 9 Pages: 1542-1543
  • DOI: 10.1038/s41433-018-0106-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Cross-Sectional and Longitudinal Study of Retinal Sensitivity in RPE65-Associated Leber Congenital Amaurosis (2018)
  • Author(s): Kumaran Neruban、Rubin Gary S.、Kalitzeos Angelos、Fujinami Kaoru、Bainbridge James W. B.、Weleber Richard G.、Michaelides Michel
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 59 Issue: 8 Pages: 3330-3330
  • DOI: 10.1167/iovs.18-23873
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 黄斑ジストロフィの分子病態 (2018)
  • Author(s): 藤波 芳、藤波（横川）優、Lizhu Yang、Xiao Liu、Gavin Arno
  • Journal Title: 眼科 Volume: 60(4) Pages: 309-321
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] POC1B関連網膜症における表現型スペクトラム：眼底正常な錐体ジストロフィ (2018)
  • Author(s): 藤波 芳
  • Journal Title: 日本眼科学会雑誌 Volume: 122(3) Pages: 251-251
• [Journal Article] Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy：East Asia Inherited Retinal Disease Consortium (EAIRDc)． (2018)
  • Author(s): 藤波 芳
  • Journal Title: 日本眼科学会雑誌 Volume: 122(4) Pages: 330-331
• [Journal Article] ISCEV extended protocol for the dark-adapted red flash ERG (2018)
  • Author(s): Thompson Dorothy A.、Fujinami Kaoru、Perlman Ido、Hamilton Ruth、Robson Anthony G.
  • Journal Title: Documenta Ophthalmologica Volume: 136 Issue: 3 Pages: 191-197
  • DOI: 10.1007/s10633-018-9644-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical Features of Japanese Patients With Anti-α-enolase Antibody?Positive Autoimmune Retinopathy: Novel Subtype of Multiple Drusen (2018)
  • Author(s): Ando Ryo、Saito Wataru、Kanda Atsuhiro、Kase Satoru、Fujinami Kaoru、Sugahara Michitaka、Nakamura Yosuke、Eguchi Shuichiro、Mori Shohei、Noda Kousuke、Shinoda Kei、Ishida Susumu
  • Journal Title: American Journal of Ophthalmology Volume: 196 Pages: 181-196
  • DOI: 10.1016/j.ajo.2018.08.044
  • Peer Reviewed
• [Journal Article] Macular dysfunction in patients with macula-on rhegmatogenous retinal detachments (2018)
  • Author(s): Akiyama Kunihiko、Fujinami Kaoru、Watanabe Ken、Noda Toru、Miyake Yozo、Tsunoda Kazushige
  • Journal Title: British Journal of Ophthalmology Volume: 103 Issue: 3 Pages: 404-409
  • DOI: 10.1136/bjophthalmol-2018-312153
  • Peer Reviewed
• [Journal Article] VALIDITY AND EFFICACY OF INTERNAL LIMITING MEMBRANE PEELING DURING INITIAL VITRECTOMY FOR RHEGMATOGENOUS RETINAL DETACHMENT (2018)
  • Author(s): Akiyama Kunihiko、Fujinami Kaoru、Watanabe Ken、Fukui Masaki、Tsunoda Kazushige、Noda Toru
  • Journal Title: Retinal Cases & Brief Reports Volume: - Issue: 2 Pages: 1-1
  • DOI: 10.1097/icb.0000000000000758
  • Peer Reviewed
• [Journal Article] East Asia Inherited Retinal Disease Consortium (EAIRDc). Stargardt disease in Asian population. (2018)
  • Author(s): Xiao Liu, Yu Fujinami-Yokokawa, Lizhu Yang, Gavin Arno, Kaoru Fujinami.
  • Journal Title: Advances in Vision Research, Volume II. Volume: 2 Pages: 279-296
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Detailed genetic characteristics of an international large cohort of patients with Stargardt disease: ProgStar study report 8 (2018)
  • Author(s): Fujinami Kaoru、Strauss Rupert W、Chiang John (Pei-Wen)、et al.
  • Journal Title: British Journal of Ophthalmology Volume: 103 Issue: 3 Pages: 390-397
  • DOI: 10.1136/bjophthalmol-2018-312064
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake窶冱 disease); EAOMD Report No.1. (2018)
  • Author(s): Fujinami K, Yang L, Joo K, Tsunoda K, Kawamura Y, Fujinami (Yokokawa) Y, Arno G, Kurihara T, Tsubota K, Zou X, Li H, Park KH, Iwata T, Miyake Y, Woo SJ, Sui R
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2018 Conference.
  • Int'l Joint Research
• [Presentation] Multimodal Imaging of East Asian Patients with Occult Macular Dystrophy (Miyake窶冱 disease) EAOMD Report No. 3. (2018)
  • Author(s): Joo K, Yang L, Tsunoda K, Kondo M, Fujinami (Yokokawa) Y, Arno G, Kurihara T, Tsubota K, Iwata T, Zou X, Li H, Miyake Y, Park KH, Fujinami K, Sui R, Woo SJ.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2018 Conference.
  • Int'l Joint Research
• [Presentation] Genotype Phenotype Association in East Asian Patients with Occult Macular Dystrophy (Miyake窶冱 disease); EAOMD Report No.4. (2018)
  • Author(s): Fujinami (Yokokawa) Y, Yang L, Joo K, Tsunoda K, Kondo M, Arno G, Liu X, Tsubota K, Iwata T, Zou X, Li H, Park KH, Miyake Y, Woo SJ, Sui R, Fujinami K.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2018 Conference.
  • Int'l Joint Research
• [Presentation] Clinical and Genetic Characteristics of East Asian Patients with Stargardt disease; EAStar Report No.1. (2018)
  • Author(s): Fujinami K, Liu X, Joo K, Tsunoda K, Hayashi T, Shinoda K, Mizota A, Kondo M, Kuniyoshi K, Fujinami (Yokokawa) Y, Yang L, Arno G, Kurihara T, Tsubota K, Miyake Y, Li Y, Park KH, Ma DJ, Yu HG, Lei B, Iwata T, Woo SJ, Li S.
  • Organizer: The 56th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Distribution of generalized functional phenotype of East Asian Patients with Stargardt Disease (STGD1): EAStar studies report 2. (2018)
  • Author(s): Liu X, Yang L, Joo K, Tsunoda K, Hayashi T, Shinoda K, Mizota A, Kondo M, Kuniyoshi K, Fujinami (Yokokawa) Y, Arno G, Kurihara T, Tsubota K, Miyake Y, Li Y, Park KH, Ma DJ, Yu HG, Lei B, Iwata T, Woo SJ, Li S, Fujinami K.
  • Organizer: The 56th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Full-field Electroretinograms Features of East Asian Patients with Occult Macular Dystrophy (Miyake窶冱 disease); EAOMD Report No.2.1. (2018)
  • Author(s): Yang L, Joo K, Tsunoda K, Mineo K, Fujinami (Yokokawa) Y, Arno G, Kurihara T, Tsubota K, Iwata T, Zou X, Li H, Park KH, Miyake Y, Woo SJ, Sui R, Fujinami K.
  • Organizer: The 56th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Genotype Phenotype Association in East Asian Patients with Occult Macular Dystrophy (Miyake窶冱 disease); EAOMD Report No.4. (2018)
  • Author(s): Fujinami (Yokokawa) Y, Yang L, Joo K, Tsunoda K, Kondo M, Arno G, Liu X, Kuriahra T, Tsubota K, Zou X, Li H, Park KH, Miyake Y, Iwata T, Woo SJ, Sui R, Fujinami K.
  • Organizer: The 56th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Influence of internal limiting membrane peeling on macular function in patients treated for macula-on rhegmatogenous retinal detachment (2018)
  • Author(s): Akiyama K, Fujinami K, Watanabe K, Noda T, Miyake Y, Tsunoda K.
  • Organizer: The 56th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Integrity of Outer Retinal Layers after Internal Limiting Membrane Peeling during Vitrectomy for Macula-on Retinal Detachment (2018)
  • Author(s): Akiyama K, Watanabe K, Fujinami K, Tsunoda K, Noda T.
  • Organizer: EURETINA Congress
  • Int'l Joint Research
• [Presentation] East Asia Inherited Retinal Disease Consortium. (2018)
  • Author(s): Fujinami K.
  • Organizer: Ophthalmic genetics seminar 2018
  • Int'l Joint Research / Invited
• [Presentation] Nationwide and international collaborative studies of inherited retinal disease: an approach from diagnosis to treatment. (2018)
  • Author(s): Fujinami K.
  • Organizer: National teaching course 2018
  • Int'l Joint Research / Invited
• [Presentation] Stargardt disease. (2018)
  • Author(s): Fujinami K.
  • Organizer: 36th World Ophthalmology Congress 2018
  • Int'l Joint Research / Invited
• [Presentation] Nationwide and international collaborative studies in Inherited retinal disorder. (2018)
  • Author(s): Fujinami K.
  • Organizer: France-Japan Collaborative Genomic Research Meeting 2018
  • Int'l Joint Research / Invited
• [Presentation] Autosomal Dominant Occult Macular Dystrophy (Miyake's disease): nationwide and international collaborative studies. (2018)
  • Author(s): Fujinami K.
  • Organizer: Germany-Japan Collaborative Research Congress 2018
  • Int'l Joint Research / Invited
• [Presentation] Nationwide and International studies of Inherited Retinal Disorders: Japan Eye Genetics Consortium and East Asia Inherited Retinal Disease. (2018)
  • Author(s): Fujinami K.
  • Organizer: The 120th Annual Meeting of the Korean Ophthalmology Society
  • Int'l Joint Research / Invited
• [Presentation] Laboratory of Visual Physiology, National Institute of Sensory Organs: history and science. (2018)
  • Author(s): Fujinami K.
  • Organizer: 1st East Asia Inherited Retinal Disease Society Seminar and Courses
  • Int'l Joint Research / Invited
• [Presentation] Paediatric Stargardt Disease (2018)
  • Author(s): Fujinami K.
  • Organizer: 1st East Asia Inherited Retinal Disease Society Seminar and Courses
  • Int'l Joint Research / Invited
• [Presentation] 中心窩剥離のない網膜剥離に対する内境界膜剥離が中心窩網膜の層構造に与える影響 (2018)
  • Author(s): 秋山邦彦、渡辺健、福井正樹、藤波芳、角田和繁、野田徹
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] 遺伝性網膜疾患におけるABCA4遺伝子多型の集団遺伝学的解析 (2018)
  • Author(s): 中伊津美、藤波優、Gavin Arno、Nikolas Pontikos、Michel Michaelides、Andrew R. Webster、藤波芳、大橋順
  • Organizer: 第72回日本人類学会大会
• [Presentation] 抗α-enolase抗体陽性自己免疫性網膜症の網膜電図所見 (2018)
  • Author(s): 安藤亮、齋藤航、神田敦宏、加瀬諭、藤波芳、菅原道孝、中村洋介、江口秀一郎、野田航介、篠田啓、石田晋
  • Organizer: 第75回日本臨床視覚電気生理学会
• [Presentation] DRAM2関連網膜症の臨床像とその長期経過 (2018)
  • Author(s): 國吉一樹，亀谷修平，林孝彰，櫻本宏之，久保田大紀，片桐 聡，藤波 芳，角田和繁，岩田岳，日下俊次
  • Organizer: 第75回日本臨床視覚電気生理学会
• [Presentation] 黄斑変性を伴った脊髄小脳変性症（SCA1）の一例 (2018)
  • Author(s): 廣瀬文音、藤波芳、野田徹、片桐聡、林孝彰、松浦知和、永井紀博、岩田岳、角田和繁
  • Organizer: 第75回日本臨床視覚電気生理学会
• [Presentation] Inherited retinal disease: an approach from diagnosis to treatment. (2018)
  • Author(s): 藤波芳
  • Organizer: 2017年度 大学共同利用機関法人 情報・システム研究機構 国立遺伝学研究所 研究会
  • Invited
• [Presentation] 遺伝性網膜疾患の診断から治療へのアプローチ (2018)
  • Author(s): 藤波芳
  • Organizer: 大阪府網膜色素変性症協会 第１５回定期総会医療講演会
  • Invited
• [Presentation] 遺伝性網膜疾患：診断から治療への考え方 (2018)
  • Author(s): 藤波芳
  • Organizer: 東京都網膜色素変性症協会医療講演会
  • Invited
• [Presentation] ABCA4遺伝子関連疾患 (2018)
  • Author(s): 藤波芳
  • Organizer: 第72回日本臨床眼科学会
  • Invited
• [Presentation] clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.1. (2018)
  • Author(s): Fujinami K, Yang L, Joo K, Tsunoda K, Kawamura Y, Fujinami (Yokokawa) Y, Arno G, Kurihara T, Tsubota K, Zou X, Li H, Park KH, Iwata T, Miyake Y, Woo SJ, Sui R
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2018 Conference.
  • Int'l Joint Research
• [Presentation] Multimodal Imaging of East Asian Patients with Occult Macular Dystrophy (Miyake’s disease) EAOMD Report No. 3. (2018)
  • Author(s): Joo K, Yang L, Tsunoda K, Kondo M, Fujinami (Yokokawa) Y, Arno G, Kurihara T, Tsubota K, Iwata T, Zou X, Li H, Miyake Y, Park KH, Fujinami K, Sui R, Woo SJ.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2018 Conference.
  • Int'l Joint Research
• [Presentation] Genotype Phenotype Association in East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.4. (2018)
  • Author(s): Fujinami (Yokokawa) Y, Yang L, Joo K, Tsunoda K, Kondo M, Arno G, Liu X, Tsubota K, Iwata T, Zou X, Li H, Park KH, Miyake Y, Woo SJ, Sui R, Fujinami K.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2018 Conference.
  • Int'l Joint Research
• [Presentation] Full-field Electroretinograms Features of East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.2.1. (2018)
  • Author(s): Yang L, Joo K, Tsunoda K, Mineo K, Fujinami (Yokokawa) Y, Arno G, Kurihara T, Tsubota K, Iwata T, Zou X, Li H, Park KH, Miyake Y, Woo SJ, Sui R, Fujinami K.
  • Organizer: The 56th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Genotype Phenotype Association in East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.4. (2018)
  • Author(s): Fujinami (Yokokawa) Y, Yang L, Joo K, Tsunoda K, Kondo M, Arno G, Liu X, Kuriahra T, Tsubota K, Zou X, Li H, Park KH, Miyake Y, Iwata T, Woo SJ, Sui R, Fujinami K.
  • Organizer: The 56th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Book] 診療で役立つ！ 近視進行予防のサイエンス (2019)
  • Author(s): 坪田 一男
  • Total Pages: 192
  • Publisher: 金原出版
  • ISBN: 9784307351713
• [Remarks] Global ABCA4 consortium
  • URL: http://www.fujinamik.com/progect
• [Remarks] NISO Global Stargardt Disease Database
  • URL: https://niso.kankakuki.go.jp/stgkarte/
• [Remarks] USA UK Japan Trilateral Collaborative Research
  • URL: http://www.fujinamik.com/progect
• [Funded Workshop] 1st East Asia Inherited Retinal Disease Society Seminar and Course (2018)