| Outline of Final Research Achievements |
In our hyper aging society, we seek the new clinical therapy and diagnostics for the locomotive syndrome, especially, osteoarthritis (OA).Pannexin 3 (Panx3), A member of gap junction family expresses in hard tissue including cartilage, inhibits cell proliferation and promotes differentiation. Panx3 channel releases intracellular small molecules and ions which turn on the intracellular signaling pathways. However, in vivo functions of Panx3 for OA are still unknown. Here, we found that Panx3 expression was promoted in the knee joint of OA mouse model. Panx3 KO mice suffered OA revealed less inflammation and degradation of articular cartilage. Further, apoptotic chondrocytes expressed Panx3 higher and released intracellular ATP, resulting the migration and accumulation of macrophages.
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