• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of hypervalent iodine catalysis for synthesis of heterocycles concomitant with introduction of carbon functional groups(Fostering Joint International Research)

Research Project

Project/Area Number 16KK0199
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Chemical pharmacy
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

SAITO Akio  東京農工大学, 工学(系)研究科(研究院), 教授 (10339103)

Project Period (FY) 2017 – 2021
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Keywords超原子価ヨウ素 / アルキン / 複素環化合物 / 芳香族化合物 / 環化反応 / 官能基化反応 / 付加環化反応 / カップリング反応 / 有機合成化学 / 触媒・化学プロセス / ヨウ素 / 複素環
Outline of Final Research Achievements

Considering the economic and environmental problems of transition metals (rare resources, toxicity, difficulty in separation and recovery, handling, etc.), which are widely used in current organic synthesis, the development of organic synthesis methods using inexpensive and low-toxic iodine, which is abundant in Japan, has been promoted in recent years. In this study, new hypervalent iodine species and their catalytic generation methods were developed for the metal-free and efficient synthesis of heterocyclic compounds found in useful materials, and applied to heterocyclic synthesis with the introduction of carbon functional groups.

Academic Significance and Societal Importance of the Research Achievements

本研究展開における「新たな超原子価ヨウ素種やその触媒的な発生法」は、有機合成化学分野や関連分野に有益な知見を提供し、さらに複素環化合物を標的としている本研究は物質供給の点で生命科学や材料科学などの他分野に大きく貢献する。また、国内で自給可能なヨウ素に付加価値を付ける取り組みは新たな産業の創出につながり、ファインケミカルズとしての実用化が可能であれば日本独自の産業として社会に与える影響は絶大である。

Report

(2 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (16 results)

All 2022 2021 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (6 results) Remarks (3 results)

  • [Int'l Joint Research] ミネソタ大学ダルース校(米国)2019

    • Year and Date
      2019-05-12
    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] トムスク工科大学(ロシア連邦)2018

    • Year and Date
      2018-08-28
    • Related Report
      2021 Annual Research Report
  • [Journal Article] Dehydrogenative Cycloisomerization/Arylation Sequence of N‐Propargyl Carboxamides with Arenes by Iodine(III)‐Catalysis2022

    • Author(s)
      Umakoshi Yuki、Takemoto Yusuke、Tsubouchi Akira、Zhdankin Viktor V.、Yoshimura Akira、Saito Akio
    • Journal Title

      Advanced Synthesis & Catalysis

      Volume: 364 Issue: 12 Pages: 2053-2059

    • DOI

      10.1002/adsc.202200219

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Preparation, Structure, and Reactivity of Pseudocyclic β‐Trifluorosulfonyloxy Vinylbenziodoxolone Derivatives2021

    • Author(s)
      Yoshimura Akira、Huss Christopher D.、Liebl Mackenzie、Rohde Gregory T.、Larson Scott M.、Frahm Gunnar B.、Luedtke Mattew W.、Schumacher Tanner J.、Gardner Zachary S.、Zhdankin Viktor V.、Postnikov Pavel S.、Yusubov Mekhman S.、Kitamura Tsugio、Saito Akio
    • Journal Title

      Advanced Synthesis & Catalysis

      Volume: 363 Issue: 13 Pages: 3365-3371

    • DOI

      10.1002/adsc.202100341

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Metal-Free Synthesis of Heterocycles via Activation of Alkynes by Hypervalent Iodine2021

    • Author(s)
      Saito Akio
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 79 Issue: 8 Pages: 766-776

    • DOI

      10.5059/yukigoseikyokaishi.79.766

    • NAID

      130008072256

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2-Iodosylbenzoic acid activated by trifluoromethanesulfonic anhydride: efficient oxidant and electrophilic reagent for preparation of iodonium salts2021

    • Author(s)
      Yoshimura Akira、Huss Christopher D.、Saito Akio、Kitamura Tsugio、Zhdankin Viktor V.
    • Journal Title

      New Journal of Chemistry

      Volume: 45 Issue: 36 Pages: 16434-16437

    • DOI

      10.1039/d1nj03787k

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Convenient Synthesis of Benziodazolone: New Reagents for Direct Esterification of Alcohols and Amidation of Amines2021

    • Author(s)
      Shea Michael T.、Rohde Gregory T.、Vlasenko Yulia A.、Postnikov Pavel S.、Yusubov Mekhman S.、Zhdankin Viktor V.、Saito Akio、Yoshimura Akira
    • Journal Title

      Molecules

      Volume: 26 Issue: 23 Pages: 7355-7355

    • DOI

      10.3390/molecules26237355

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ビスラクタム型超原子価ヨウ素を活用したペプチド合成法2022

    • Author(s)
      上原泰悟, 坪内彰介, 齊藤亜紀夫
    • Organizer
      日本薬学会 第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] in situ調製したイミノヨーダンによるアルデヒドのイミン化反応の開発2022

    • Author(s)
      砂川駿, 坪内彰介, 齊藤亜紀夫
    • Organizer
      日本薬学会 第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Barluenga試薬を用いたo-アルキニルアニリン誘導体の触媒的環化-アリル化反応2022

    • Author(s)
      津端紗絵, 坪内彰介, 齊藤亜紀夫
    • Organizer
      日本薬学会 第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] N-フルオロピリジニウム塩による7-エン-2-イノン類の環化異性化反応2022

    • Author(s)
      佐藤大介, 齊藤亜紀夫
    • Organizer
      日本薬学会 第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 7-エン-2-イノン誘導体からのハロゲン導入型ビシクロ[3.1.0]ヘキサン骨格構築法2021

    • Author(s)
      佐藤大介, 齊藤亜紀夫
    • Organizer
      第47回 反応と合成の進歩シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 有機スルホンを酸化剤とする三価ヨウ素試薬の発生法2021

    • Author(s)
      馬越 優貴, 齊藤亜紀夫
    • Organizer
      第47回 反応と合成の進歩シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Remarks] 東京農工大学工学部応用分子化学科 齊藤研究室

    • URL

      http://web.tuat.ac.jp/~akio-sai/index.html

    • Related Report
      2021 Annual Research Report
  • [Remarks] 齊藤 亜紀夫 - 研究者プロフィール

    • URL

      http://kenkyu-web.tuat.ac.jp/Profiles/44/0004321/profile.html

    • Related Report
      2021 Annual Research Report
  • [Remarks] グローバルイノベーション研究院_教員紹介_齊藤亜紀夫

    • URL

      https://www.tuat-global.jp/researcher/c-1270-2013/

    • Related Report
      2021 Annual Research Report

URL: 

Published: 2017-03-15   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi