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Development of therapeutic effect prediction method and cancer therapy enhancement method for internal radiation therapy (Fostering Joint International Research)

Research Project

Project/Area Number 16KK0200
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

Kobayashi Masato  金沢大学, 保健学系, 准教授 (30444235)

Project Period (FY) 2017 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Keywords核医学 / イメージング / SPECT / 排泄型薬物トランスポータ / 内用放射線治療 / [131I]MIBG / トランスポータ / 多剤耐性 / がん / 個別化治療 / 放射性薬剤
Outline of Final Research Achievements

In this study, we aimed to improve the therapeutic effect of [131I] MIBG, an internal radiotherapy with radiopharmaceuticals for cancer, by using a method for predicting the therapeutic effect of [131I] MIBG and develop the cancer therapy enhancement method with combination of [131I] MIBG and the specific inhibitors for efflux transporter from cancer cells.In international collaborators in the United States, [131I] MIBG was excreted outside cancer cells via MRP1 and MRP4 in human-derived neuroblastoma cell line SK-N-SH, which is the target of treatment of [131I] MIBG. cancer cells. In addition, we have developed the cancer therapy enhancement method by using MRP-specific inhibitor MK-571 and probenecid to retain [131I] MIBG in cancer cells.

Academic Significance and Societal Importance of the Research Achievements

本国際共同研究では、小児がんの神経芽細胞腫に対する内用放射線治療薬[131I]MIBGの治療効果予測法と、[131I]MIBGのがん治療効果増強法の開発に成功した。本研究成果により、[131I]MIBG投与前に、[131I]MIBGを用いた神経芽細胞腫に対する治療効果を予測できる。また、[131I]MIBGのがん細胞排泄阻害剤を併用投与することで、[131I]MIBGのがん治療効果を増強できる可能性を示した。

Report

(2 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (7 results)

All 2020 2019 2018

All Int'l Joint Research (3 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] スタンフォード大学(米国)2019

    • Year and Date
      2019-03-24
    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] テキサス大学MDアンダーソンがんセンター(米国)2018

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] 米国国立衛生研究所(米国)2018

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Transport mechanism and affinity of [99mTc]mercaptoacetyltriglycine ([99mTc]MAG3) on the apical membrane of renal proximal tubule cells.2020

    • Author(s)
      Kobayashi M, Nishi K, Mizutani A, Okudaira H, Nakanishi T, Shikano N, Nishii R, Tamai I, Kawai K.
    • Journal Title

      Nuclear Medicine and Biology.

      Volume: 84-85 Pages: 33-37

    • DOI

      10.1016/j.nucmedbio.2020.01.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of Hepatic Drug Transporters with [131I]6-β-iodomethyl-19-norcholesterol.2019

    • Author(s)
      Kobayashi M., Nishi K., Mizutani A., Hokama T., Matsue M., Tsujikawa T., Nakanishi T., Nishii R., Tamai I., Kawai K.
    • Journal Title

      Sci. Rep.

      Volume: 9 Issue: 1 Pages: 13413-13413

    • DOI

      10.1038/s41598-019-50049-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Patent(Industrial Property Rights)] 細菌感染症の放射性診断薬2019

    • Inventor(s)
      川井恵一,小林正和,水谷明日香,岡本成史
    • Industrial Property Rights Holder
      川井恵一,小林正和,水谷明日香,岡本成史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 細菌又は細胞の分類方法,アミノ酸の輸送特性の分類方法,菌感染の診断補助方法並びに癌の診断補助方法2019

    • Inventor(s)
      川井恵一,小林正和,水谷明日香,岡本成史
    • Industrial Property Rights Holder
      川井恵一,小林正和,水谷明日香,岡本成史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2017-03-15   Modified: 2021-02-19  

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