| Outline of Final Research Achievements |
To understand behavioral and psychological symptoms of dementia, grasping emotional changing in the patient in very important. We developed the rating scales of facial expression and affective vocal sounds which can evaluate by combined the elements of intensity, balance, and arousal. Further, It is known that β-amyloid and phosphorylated tau protein accumulate before dementia symptoms appear. However, how various brain functions are altered by amyloid and tau accumulation has not been examined. Using molecular imaging, we confirmed that by accumulation of phosphorylated tau, functional connectivities were reducing between the dorsal midbrain and the posterior cingulate gyrus, which are part of the default mode network, and changes brain function.
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