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A novel model for causing senescence via mitochondrial dysfunction by environmental factors

Research Project

Project/Area Number 16KT0013
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Neo-Gerontology
Research InstitutionCenter for Novel Science Initatives, National Institutes of Natural Sciences (2018)
Okazaki Research Facilities, National Institutes of Natural Sciences (2016-2017)

Principal Investigator

Nishida Motohiro  大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授 (90342641)

Co-Investigator(Kenkyū-buntansha) 藤井 重元  東北大学, 医学系研究科, 大学院非常勤講師 (00325333)
赤池 孝章  東北大学, 医学系研究科, 教授 (20231798)
本橋 ほづみ  東北大学, 加齢医学研究所, 教授 (00282351)
Research Collaborator Nishimura Akiyuki  
Tanaka Tomohiro  
Nishiyama Kazuhiro  
Project Period (FY) 2016-07-19 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsミトコンドリア / 老化 / 心臓 / 環境因子 / レドックス / イオウ / 創薬 / 活性イオウ / 親電子 / 細胞老化 / 酸化ストレス / Gタンパク質 / ストレス適応 / 環境対応 / 活性イオウ分子 / 親電子シグナル
Outline of Final Research Achievements

Mitochondria are dynamic organella that can change its structure and morphology by repeating fission and fussion cycle, and its quality control is essential for maintenance of body health. In this study, we aimed to reveal the influence of environmental factors on mitochondrial quality and early senescence in view of redox signaling, and identify a novel anti-aging drug. We found that dynamin-related protein 1 (Drp1), a mitochondrial fission-promoting protein, forms polysulfide (Cys-SSH) in protein and depolysulfidation of Drp1 by environmental electrophiles triggered Drp1 activation, which led to mitochondrial fission-mediated myocardial early senescence, resulting in causing cardiac vulnerability against hemodynamic load in mice.

Academic Significance and Societal Importance of the Research Achievements

タンパク質に含まれるCysポリイオウ鎖が環境親電子物質の代謝・消去を担う内因性求核物質の実体となり、環境親電子物質曝露の蓄積がミトコンドリア過剰分裂を介して心筋早期老化を誘導するという新たな機構を解明したこと、さらにこれを選択的に抑制する既承認薬シルニジピンが慢性心不全を改善させるという知見をマウスで得たことは基礎・臨床の両面において意義深い。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (72 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (25 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 25 results,  Open Access: 24 results,  Acknowledgement Compliant: 3 results) Presentation (37 results) (of which Int'l Joint Research: 9 results,  Invited: 14 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] サバ大学(マレーシア)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] マヒドン大学(タイ)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] サバ大学医学部(マレーシア)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] マヒドール大学薬学部(タイ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Catholic University of Argentina(アルゼンチン)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] NIEHS(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Mitochondrial dynamics in exercise physiology.2019

    • Author(s)
      Tanaka T, Nishimura A, Nishiyama K, Goto T, Numaga-Tomita T, Nishida M.
    • Journal Title

      Pflugers Archiv European Journal of Physiology

      Volume: 印刷中 Issue: 2 Pages: 1-17

    • DOI

      10.1007/s00424-019-02258-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons2018

    • Author(s)
      Masuda Kumiko、Tsutsuki Hiroyasu、Kasamatsu Shingo、Ida Tomoaki、Takata Tsuyoshi、Sugiura Kikuya、Nishida Motohiro、Watanabe Yasuo、Sawa Tomohiro、Akaike Takaaki、Ihara Hideshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Issue: 3 Pages: 2165-2170

    • DOI

      10.1016/j.bbrc.2017.12.088

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.2018

    • Author(s)
      Sunggip C, Shimoda K, Oda S, Tanaka T, Nishiyama K, Mangmool S, Nishimura A, Numaga-Tomita T and Nishida M
    • Journal Title

      Front. Pharmacol.

      Volume: 9 Pages: 523-523

    • DOI

      10.3389/fphar.2018.00523

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.2018

    • Author(s)
      Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.
    • Journal Title

      Sci Signal

      Volume: 11 Issue: 556 Pages: 5185-5195

    • DOI

      10.1126/scisignal.aat5185

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells2018

    • Author(s)
      Parichatikanond Warisara、Nishimura Akiyuki、Nishida Motohiro、Mangmool Supachoke
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 138 Issue: 3 Pages: 184-191

    • DOI

      10.1016/j.jphs.2018.09.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 2-Oxo-histidine-containing dipeptides are functional oxidation products2018

    • Author(s)
      Ihara Hideshi、Kakihana Yuki、Yamakage Akane、Kai Kenji、Shibata Takahiro、Nishida Motohiro、Yamada Ken-ichi、Uchida Koji
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 4 Pages: 1279-1289

    • DOI

      10.1074/jbc.ra118.006111

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling2018

    • Author(s)
      Sawa Tomohiro、Ono Katsuhiko、Tsutsuki Hiroyasu、Zhang Tianli、Ida Tomoaki、Nishida Motohiro、Akaike Takaaki
    • Journal Title

      Advances in Microbial Physiology

      Volume: 72 Pages: 1-28

    • DOI

      10.1016/bs.ampbs.2018.01.002

    • ISBN
      9780128144138
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy2017

    • Author(s)
      Shimauchi Tsukasa、Numaga-Tomita Takuro、Ito Tomoya、Nishimura Akiyuki、Matsukane Ryosuke、Oda Sayaka、Hoka Sumio、Ide Tomomi、Koitabashi Norimichi、Uchida Koji、Sumimoto Hideki、Mori Yasuo、Nishida Motohiro
    • Journal Title

      The JCI insight

      Volume: 2 Issue: 15 Pages: 93358-93358

    • DOI

      10.1172/jci.insight.93358

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway2017

    • Author(s)
      Phosri Sarawuth、Arieyawong Ajaree、Bunrukchai Kwanchai、Parichatikanond Warisara、Nishimura Akiyuki、Nishida Motohiro、Mangmool Supachoke
    • Journal Title

      Frontiers in Pharmacology

      Volume: 8 Pages: 428-428

    • DOI

      10.3389/fphar.2017.00428

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice2017

    • Author(s)
      Oda Sayaka、Numaga-Tomita Takuro、Kitajima Naoyuki、Toyama Takashi、Harada Eri、Shimauchi Tsukasa、Nishimura Akiyuki、Ishikawa Tatsuya、Kumagai Yoshito、Birnbaumer Lutz、Nishida Motohiro
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 7511-7511

    • DOI

      10.1038/s41598-017-07903-4

    • NAID

      120007128849

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy2017

    • Author(s)
      Guan Yu、Nakano Daisuke、Zhang Yifan、Li Lei、Liu Wenhua、Nishida Motohiro、Kuwabara Takashige、Morishita Asahiro、Hitomi Hirofumi、Mori Kiyoshi、Mukoyama Masashi、Masaki Tsutomu、Hirano Katsuya、Nishiyama Akira
    • Journal Title

      J Pharmacol Sci

      Volume: 135 Issue: 2 Pages: 81-88

    • DOI

      10.1016/j.jphs.2017.09.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics2017

    • Author(s)
      Akaike Takaaki、、、Nishida Motohiro(4)、、、、、、Fujii Shigemoto(20)、、、Motohashi Hozumi(26)
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1177-1177

    • DOI

      10.1038/s41467-017-01311-y

    • NAID

      120007134656

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells2017

    • Author(s)
      Ihara Hideshi、Kasamatsu Shingo、Kitamura Atsushi、Nishimura Akira、Tsutsuki Hiroyasu、Ida Tomoaki、Ishizaki Kento、Toyama Takashi、Yoshida Eiko、Abdul Hamid Hisyam、Jung Minkyung、Matsunaga Tetsuro、Fujii Shigemoto、Sawa Tomohiro、Nishida Motohiro、Kumagai Yoshito、Akaike Takaaki
    • Journal Title

      Chem. Res. Toxicol

      Volume: 30 Issue: 9 Pages: 1673-1684

    • DOI

      10.1021/acs.chemrestox.7b00120

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells2017

    • Author(s)
      Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T.
    • Journal Title

      Free Radic Biol Med.

      Volume: 印刷中 Pages: 30033-3

    • DOI

      10.1016/j.freeradbiomed.2017.01.024

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPC3 Channels in Cardiac Fibrosis2017

    • Author(s)
      Numaga-Tomita Takuro、Oda Sayaka、Shimauchi Tsukasa、Nishimura Akiyuki、Mangmool Supachoke、Nishida Motohiro
    • Journal Title

      Frontiers in Cardiovasc Med

      Volume: 4 Pages: 56-56

    • DOI

      10.3389/fcvm.2017.00056

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension.2017

    • Author(s)
      Sunggip Caroline, Nishimura Akiyuki, Shimoda Kakeru, Numaga-Tomita Takuro, Tsuda Makoto, Nishida Motohiro
    • Journal Title

      Pharmacol Res.

      Volume: 120 Pages: 51-59

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases.2017

    • Author(s)
      Nishimura Akiyuki, Sunggip Caroline, Oda Sayaka, Numaga-Tomita Takuro, Tsuda Makoto, Nishida Motohiro
    • Journal Title

      Pharmacol Ther.

      Volume: 17 Pages: 30158-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.2017

    • Author(s)
      Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
    • Journal Title

      J Am Heart Assoc.

      Volume: 6 Issue: 2

    • DOI

      10.1161/jaha.116.003601

    • NAID

      120007100125

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes2017

    • Author(s)
      Yamaguchi Y, Iribe G, Kaneko T, Takahashi K, Numaga-Tomita T, Nishida M, Birnbaumer L, Naruse K.
    • Journal Title

      J. Physiol. Sci.

      Volume: 印刷中 Issue: 2 Pages: 1-12

    • DOI

      10.1007/s12576-016-0519-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.2016

    • Author(s)
      Numaga-Tomita T., Kitajima N., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 39383-39383

    • DOI

      10.1038/srep39383

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.2016

    • Author(s)
      Kitajima N., Numaga-Tomita T., Watanabe M., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 37701-37701

    • DOI

      10.1038/srep37001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells2016

    • Author(s)
      Unoki T, Abiko Y, Toyama T, Uehara T, Tsuboi K, Nishida M, Kaji T, Kumagai Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 28944-28944

    • DOI

      10.1038/srep28944

    • NAID

      120007135346

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor2016

    • Author(s)
      M. Hagimori, T. Murakami, K. Shimizu, M. Nishida, T. Ohshima, T. Mukai
    • Journal Title

      MedChemComm

      Volume: 7 Issue: 5 Pages: 1003-1006

    • DOI

      10.1039/c6md00023a

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides2016

    • Author(s)
      Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, Akaike T.
    • Journal Title

      Arch Biochem Biophys.

      Volume: 595 Pages: 140-146

    • DOI

      10.1016/j.abb.2015.11.008

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Redox signaling regulated by electrophiles and reactive sulfur species2016

    • Author(s)
      Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 2 Pages: 91-98

    • DOI

      10.3164/jcbn.15-111

    • NAID

      130005132519

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Mitochondrial quality control and its metabolic regulation by reactive persulfide species2019

    • Author(s)
      Motohiro Nishida
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mitochondrial metabolic regulation by RSS2018

    • Author(s)
      西田基宏
    • Organizer
      Cardiovascular and Metabolic Week (CVMW) 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Drug repositioning of cilnidipine, a dyhydropyridine-derivative calcium channel blocker2018

    • Author(s)
      西田基宏
    • Organizer
      The 1st JCS Council Forum on Basic CardioVascular Reseach (BCVR)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心不全リスクを制御するレドックスシグナル2018

    • Author(s)
      西田基宏
    • Organizer
      日本酸化ストレス学会東海支部 第6回学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 心筋恒常性のレドックス制御2018

    • Author(s)
      西田基宏
    • Organizer
      第15回レドックス・ライフイノベーションシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 活性イオウによる心筋ミトコンドリア品質管理のレドックス制御2018

    • Author(s)
      西田基宏
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心不全治療の新たな標的としてのイオウ代謝2018

    • Author(s)
      西田基宏
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 活性イオウによるDrp1多量体化を介した心筋リモデリング制御2018

    • Author(s)
      西田基宏
    • Organizer
      第71回日本酸化ストレス学会/第18回日本NO学会合同学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 活性イオウによるミトコンドリア品質管理の二面的制御2018

    • Author(s)
      西田基宏
    • Organizer
      第45回日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Ca2+チャネル研究から見えてきたドラッグ・リポジショニング2018

    • Author(s)
      西田基宏
    • Organizer
      第17回九州脳・高血圧・循環制御研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] タンパク質中の活性イオウによるミトコンドリア品質管理制御2018

    • Author(s)
      西田基宏
    • Organizer
      第72回日本細菌学会東北支部総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] レドックスシグナルから考えるプラズマ生物学2018

    • Author(s)
      西田基宏
    • Organizer
      第一回プラズマバイオコンソーシアムワークショップ
    • Related Report
      2018 Annual Research Report
  • [Presentation] GPCR/Gタンパク質のレドックス修飾に着目した創薬2018

    • Author(s)
      西田基宏
    • Organizer
      レドックス・ライフイノベーション第170委員会/日本におけるケミカルバイオロジーの新展開第189委員会合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Ca2+チャネル研究から見えてきたドラッグ・リポジショニング2018

    • Author(s)
      西田基宏
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心臓にコミットする:心臓を鍛えるのに、いい薬はありませんか?2018

    • Author(s)
      西田基宏
    • Organizer
      第71回日本薬理学会西南部会・市民公開講座「薬物治療の疑問に答える4つの話」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Ca2+チャネル研究から見えてきたドラッグ・リポジショニング2018

    • Author(s)
      西田基宏
    • Organizer
      Advans研究会2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mitochondrial metabolic regulation by reactive sulfide species.2018

    • Author(s)
      Motohiro Nishida
    • Organizer
      IUBMB (Seoul, Korea)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mitochondrial quality control and its metabolic regulation by reactive persulfide species.2018

    • Author(s)
      Motohiro Nishida
    • Organizer
      the International Conference of the Korean Society for Molecular and Cellular Biology (KSMCB2018, Seoul, Korea)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New strategies of drug repositioning for the maintenance of mitochondrial quality.2018

    • Author(s)
      Motohiro Nishida
    • Organizer
      Symposium in Inje University ‘Interactions. Dynamic rescue of affected mitochondria (Dream)’ (Inje University, Busan, Korea)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cardiovascular Aging Regulated by Heterodimerization of Angiotensin AT1 Receptor with Purinergic P2Y6 Receptor2018

    • Author(s)
      Motohiro Nishida
    • Organizer
      Angiotensin Gordon Research Conference 2018.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism underlying redox regulation of cardiac mitochondria dynamics2017

    • Author(s)
      Nishida M
    • Organizer
      The 94th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Actcity Hamamatsu, Hamamatsu,Shizuoka
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ジヒドロピリジン系Ca2+拮抗薬シルニジピンのエコファーマ研究2017

    • Author(s)
      西田基宏
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール、長崎県長崎市
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Metabolic detoxification of environmental electrophile by reactive cysteine persulfides.2017

    • Author(s)
      Motohiro Nishida
    • Organizer
      Korea/Russia joint symposium 2017 (Marine Effective compounds Open Wellness)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ミトコンドリアダイナミクスのレドックス制御2017

    • Author(s)
      西田基宏
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] TRPC3-Nox2複合体形成による心筋可塑性制御2017

    • Author(s)
      西田基宏
    • Organizer
      Research PlaNet
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 活性イオウによるミトコンドリア品質管理と心疾患リスク制御2017

    • Author(s)
      西田基宏
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Research-status Report
  • [Presentation] TRPチャネル複合体を標的とした心不全治療戦略2017

    • Author(s)
      西田基宏
    • Organizer
      iHFフォーラム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] GTP結合タンパク質Drp1のシステイン修飾を介した心筋早期老化の分子制御機構と創薬への適用2017

    • Author(s)
      西田基宏
    • Organizer
      薬学会薬理系部会 生体機能と創薬シンポジウム2017
    • Related Report
      2017 Research-status Report
  • [Presentation] 心不全リスクを制御するレドックスシグナル2017

    • Author(s)
      西田基宏
    • Organizer
      Molecular Cardiovascular Metabolic Conference (MCMC) 2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 心血管病の新たな標的としてのTRPC3-Nox2複合体2017

    • Author(s)
      西田基宏
    • Organizer
      第40回日本高血圧学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] シルニジピンによるミトコンドリア品質維持と適応拡大2017

    • Author(s)
      西田基宏
    • Organizer
      第27回日本医療薬学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] ミトコンドリア品質管理に着目した新しい疾患治療戦略2017

    • Author(s)
      西田基宏
    • Organizer
      第27回日本循環薬理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Cardiac mitochondrial quality control by reactive sulfide species.2017

    • Author(s)
      Motohiro Nishida
    • Organizer
      ConBio2017(国際シンポジウム)
    • Related Report
      2017 Research-status Report
  • [Presentation] Myocardial early senescence mediated by mitochondria-cytoskeleton interaction2016

    • Author(s)
      Nishida M
    • Organizer
      The 39th Annual Meeting of the Molecular Biology Society of Japan (international symposium)
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Regulation of cardiac oxygen remodeling via electrophilic modification of Drp12016

    • Author(s)
      Nishida M
    • Organizer
      The 89th Annual Meeting of the Japanese Biochemical Society (international symposium)
    • Place of Presentation
      Sendai International Conference Center, Sendai, Miyagi
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 活性イオウによる心筋のストレス適応・不適応の分子制御2016

    • Author(s)
      西田基宏
    • Organizer
      第159回日本獣医学会比較薬理毒性分科会
    • Place of Presentation
      日本大学、神奈川県藤沢市
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] メチル水銀による心不全リスク増加の分子機構2016

    • Author(s)
      西田基宏
    • Organizer
      環境省メチル水銀研究会
    • Place of Presentation
      LMJ東京研修センター、東京都文京区
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks] 心循環シグナル研究部門

    • URL

      http://www.nips.ac.jp/circulation/

    • Related Report
      2018 Annual Research Report 2017 Research-status Report 2016 Research-status Report
  • [Remarks] 世界初:哺乳類における「硫黄呼吸」を発見 - 酸素に依存しないエネルギー代謝のメカニズムを解明 -

    • URL

      https://www.tohoku.ac.jp/japanese/2017/10/press20171025-02.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 抗がん剤で心筋が萎縮する機序を解明

    • URL

      http://www.nips.ac.jp/release/2017/08/post_347.html

    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] ベンゾイソオキサゾール化合物2018

    • Inventor(s)
      永田龍、森泰生、西田基宏、森誠之、冨田拓郎
    • Industrial Property Rights Holder
      大阪大学、京都大学、自然科学研究機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-086929
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-07-20   Modified: 2023-03-08  

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