Sustainable control of pathogens and beneficial endophytes with tryptophan-derived metabolism in plants
| Project/Area Number |
16KT0031
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Food Cycle Research
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
Saijo Yusuke 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 (50587764)
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| Co-Investigator(Kenkyū-buntansha) |
中尾 佳亮 京都大学, 工学研究科, 教授 (60346088)
藤田 美紀 国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 (70332294)
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| Research Collaborator |
HIRUMA kei
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| Project Period (FY) |
2016-07-19 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | 共生 / 植物 / 微生物 / 二次代謝 / 病害抵抗性 / 植物微生物相互作用 / 化学合成 / 植物免疫 / 内生菌 / 環境調和型植物生産 / 内生菌・共生菌 / 植物成長・生理 / 植物分子生理学 / 植物代謝調節 / 生体分子 / 有機化学 |
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| Outline of Final Research Achievements |
To exploit beneficial plant-inhabiting microbes and repel plant pathogens, we investigate into the mechanisms by which plants accommodate pathogens without discernible disease symptoms. We reveal the endophytic fungus Colletotrichum spp (CgE) from radish roots, which colonize and protects the host from pathogens' infection and diseases. Co-inoculation of CgE restricts the growth of different root-infecting pathogenic fungi in Brassicaceae plants. Genetic studies in Arabidopsis thaliana indicate a critical role for ethylene-mediated defenses and tryptophan-derived antimicrobial metabolites of the host in CgE-mediated plant protection. We also reveal several host metabolites, of which exogenous application is effective in the proper control of CgE and host protection. Moreover, comparative genomics studies between CgE and its pathogenic relatives and transcriptome profiling of CgE-colonized plants gain important insight into the basis for endophyte-mediated plant protection.
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| Academic Significance and Societal Importance of the Research Achievements |
持続的な食料生産技術の開発は世界的に喫緊の課題である。中でも、植物生産に甚大な被害を与える病原糸状菌（カビ）に対する作物保護技術を確立すること、並びに環境に低負荷で植物生産の増加を図ることは極めて重要な位置付けにある。植物が体表や組織内に病気を起こさずに宿している多様な共棲菌には植物の成長補助や生体防御に貢献するものが知られ、低肥料・持続型農業のシーズとして高い期待を集めている。したがって、上記の成果をベースに、一見相反する「病原糸状菌の防除」と「有用共棲菌の活用」を両立する技術の開発を推進することの意義は大きい。また、有効性が示された研究手法も他の系に活用が可能で、波及効果も期待できる。
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis.2018
Author(s)
Ogita N, Okushima Y, Tokizawa M, Yamamoto YY, Tanaka M, Seki M, Makita Y, Matsui M, Okamoto-Yoshiyama K, Sakamoto T, Kurata T, Hiruma K, Saijo Y, Takahashi N, Umeda M.
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Journal Title
The Plant Journal
Volume: -
Issue: 3
Pages: 439-453
DOI
Related Report
Peer Reviewed / Open Access
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