| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
The molecular mechanism of the peroxidase activity of a complex composed of a G-quadruplex DNA formed from guanine-rich DNA and heme, found as prosthetic groups of various hemoproteins abundant in nature, has been elucidated. A water molecule (H2O) is located at the interface between the heme and DNA in the complex and is coordinated to the heme Fe atom. We found that the axial H2O in the complex is capable of being an electron-donating ligand which increases the Lewis basicity of the heme Fe atom to facilitate heterolytic O-O bond cleavage of Fe-bound peroxide (H2O2) to promote the formation of a high-valent iron(IV)oxo porphyrin π-cation radical.
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