| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
Novel Transition-metal-catalyzed annulation reactions have been developed in this study. Efficient constructions of cyclic molecular frameworks involving multiple bond formations were achieved using ruthenium, rhodium, and palladium complexes as the catalysts. Density functional theory calculations were performed to analyze reaction mechanisms and the obtained results were utilized for further reaction developments. Furthermore, novel sequential synthetic processes were developed by integrating the newly established transition-metal-catalyzed annulations with other reactions, and were applied to the synthesis of derivatives of seco-prezizaane-type sesquiterpeneoid, jiadifenolide, and bioactive heterocyclic compounds, benzosimuline.
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