| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
The regulation of gene expression is the output of complicated system which involves multiple transcription factors. In order to unveil the whole view of this gene-regulation system, the information regarding not only the transcriptome as the output of this system, but also the activity of various transcription-factors are necessary. In this research, we quantitatively analyzed over 50 activity dependent transcription factors in cultured neurons by our newly developed “transcription-factor-reporter virus” and succeeded to obtain the time-course of their activity changes upon neuronal activity enhancement. This research established a novel method to analyze the mechanisms involved in the development of brain function and learing and memory of animals.
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