| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
Vascular networks play pivotal roles in a variety of biological functions in the body. Blood vessels also contribute to cancer metastasis. This study aimed at understanding the mechanisms by which the vascular networks are patterned during early development using chicken embryos. Exploiting a flat structure of early embryo in which vascular morphogenesis proceeds, we have developed a method enabling visualization of individual endothelial cells during vascular remodeling. We have found that a subtle difference in blood flow results in a differentiation of disappearing vessels and thickening ones, leading to an overt patterning of vascular structures.
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