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The basic design of post-hatch development of the pallium and examination of its emergent properties

Research Project

Project/Area Number 16KT0072
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Constructive Systems Biology
Research InstitutionOkayama University

Principal Investigator

TAKEUCHI Hideaki  岡山大学, 自然科学研究科, 准教授 (00376534)

Co-Investigator(Kenkyū-buntansha) 中村 遼平  東京大学, 大学院理学系研究科(理学部), 助教 (30756458)
Research Collaborator ISOE Yasuko  
KAMEI Yasuhiro  
NONAKA Shigenori  
Project Period (FY) 2016-07-19 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywords神経新生 / 脳発達 / 細胞系譜単位 / 顔領域 / クローナルユニット / パリウム / ATAC-Seq / RNA-Seq
Outline of Final Research Achievements

The telencephalon can be subdivided into the pallium (dorsal part) and subpallium (ventral part). The pallium consists of multiple compartmentalized anatomical regions. In this study, we found that the individual anatomical regions of the pallium comprise multiple clonal units of new-born neurons. Each clonal unit was generated from a single progenitor cell during the post-hatch stage. Here we dissected clonal units (about 30 units), which were genetically labeled with GFP, and compared open chromatin profiles using ATAC-Seq. Here we showed significant difference of profiles between the pallium and subpallium. In addition, individual clonal units have specific profiles, suggesting that epigenetic modification might regulate gene expression of the clonal units and “lineage diversity” could generate compartmentalized structures of the pallium.

Academic Significance and Societal Importance of the Research Achievements

脊椎動物の大脳背側パリウム(大脳皮質)は、記憶・学習や社会認知等の脳の高次能機能に関わっている。魚類から哺乳類までパリウムは解剖学的に明確に区画化されており、パリウムは各区画によって機能分担されていると考えられている。これまでパリウムを区画化する仕組みは不明であった。本研究ではメダカ成体脳のパリウムを構成する脳区画が生後の脳発達段階で生まれた新生ニューロンの細胞系譜単位に対応しており、各細胞系譜単位は特徴的なエピゲノムパターンを持つことを世界に先駆けて発見した。今後、本研究を足場にして生後の脳発達期に社会認知機能などの高次脳機能が発達する仕組みを分子レベルで解明できることが期待される。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (17 results)

All 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results) Book (2 results) Remarks (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Emory University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ハイデルベルグ大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] エモリー大学(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ハイデルベルグ大学/カールスルーエ工科大学(ドイツ)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Molecular basis of social competence in medaka fish2017

    • Author(s)
      Teruhiro Okuyama, Saori Yokoi, Hideaki Takeuchi
    • Journal Title

      Development, Growth, Differentiation

      Volume: 59 Issue: 4 Pages: 211-218

    • DOI

      10.1111/dgd.12359

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The molecular basis underlying social behaviors in medaka fish2019

    • Author(s)
      Hideaki Takeuchi
    • Organizer
      The Third Sino-Japan Symposium on the Frontier of Behavioral Neuroendocrinology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Social peptides in medaka fish2018

    • Author(s)
      Hideaki Takeuchi
    • Organizer
      International workshop on “UNDERSTANDING THE NEUROREGULATORY ACTIONS OF OXYTOCIN AND ITS POTENTIAL CLINICAL APPLICATIONS”
    • Related Report
      2018 Annual Research Report
  • [Presentation] Individual recognition in medaka fish2018

    • Author(s)
      Hideaki Takeuchi
    • Organizer
      4rd Medaka Strategic Meeting
    • Related Report
      2018 Annual Research Report
  • [Presentation] メダカを用いた社会障害の原因となる分子基盤の解析2018

    • Author(s)
      竹内秀明
    • Organizer
      日本農芸化学会2018年度(平成30年度)大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] The Neural/ Molecular Basis underlying Social Recognition in Medaka Fish2018

    • Author(s)
      Hideaki Takeuchi
    • Organizer
      28th Japanese Society for Behavioral Neuroendocrinology (JSBN)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] MOLECULAR BASIS UNDERLYING SOCIAL COMPETENCE IN MEDAKA FISH2017

    • Author(s)
      Hideaki Takeuchi
    • Organizer
      18th International Congress of Comparative Endocrinology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular basis underlying fish social competence ~ Social Neuropeptide in medaka fish.2017

    • Author(s)
      Hideaki Takeuchi
    • Organizer
      Symposium on Oxytocin and Social Behavior: Animal and Human Studies toward ASD Pathophysiology and Therapeutic Effects
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] メダカの個体認知を介した配偶者選択とそ分子神経基盤2017

    • Author(s)
      竹内秀明
    • Organizer
      日本実験動物技術者協会関西支部主催シンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] メダカの個体認知能力と配偶者選択2018

    • Author(s)
      王牧芸、横井佐織、奥山輝大、竹内秀明
    • Total Pages
      7
    • Publisher
      『生物の科学 遺伝』 エヌ・ティー・エス
    • ISBN
      9784860435936
    • Related Report
      2018 Annual Research Report
  • [Book] メダカの行動学研究の最先端~メダカはなぜ豊かな色彩を持つのか?2018

    • Author(s)
      竹内秀明、深町昌司、亀井保博、成瀬清
    • Total Pages
      3
    • Publisher
      『生物の科学 遺伝』 エヌ・ティー・エス
    • ISBN
      9784860435936
    • Related Report
      2018 Annual Research Report
  • [Remarks] 岡山大学大学院自然科学研究科(理学部生物学科) 分子行動学研究室

    • URL

      https://sites.google.com/view/molecular-ethology-laboratory/

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Funded Workshop] "Molecular basis underlying social competence" The International Behavioral Neuroscience Society for the 26th Annual Meeting2017

    • Related Report
      2017 Research-status Report

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Published: 2016-07-20   Modified: 2023-03-08  

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