| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Outline of Final Research Achievements |
G-protein coupled receptors (GPCRs) are involved in various physiologies, and therefore have been studied not only for understanding the mechanisms underlying biological activities but also drug discovery. However, a significant number of GPCRs are still orphan receptors, whose input and output remain unknown. In this study, we developed a new method for understanding outputs of orphan GPCRs by using photoreceptor proteins and light as an input. We investigated molecular basis of varied animal photoreception including vision to discover photoreceptor proteins having interesting characteristics such as "dark-active and light-inactivated opsin", "UV-active and green-inactive opsin" and "the longest wavelength sensitive bistable opsin". These opsins could be promising optogenetic tools for analyzing orphan GPCRs.
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