| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
In animal development, a group of cells in a tissue are often polarized in the same orientation. Although such polarity is controlled by Wnt signaling, the mechanism regulating polarity orientation is poorly understood. We have found that polarity orientation of hypodermal stem cells in C. elegans is controlled by both gradient dependent and independent functions of Wnts. One of the Wnt receptor CAM-1/Ror is expressed in graded manner; higher in the anterior side of the body. Reversing this graded expression caused reversal of cell polarity. In addition, combined mutations of the Hox genes disrupted polarity. The results raised a possibility that polarity orientation is regulated by graded expression of the Wnt receptor that is established by the Hox genes.
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