| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
We succeeded in reproducing well the observed temporal change of the limb bud shape by mechanical simulations that include stress-dependent epithelial tissue growth. These results suggest the importance of the mechanical response of epithelial tissues in determining limb morphogenesis and were published in [Kida and Morishita, Finite Elem Anal Des, 2018]. In addition, laser ablation experiments and tissue tension tests revealed (i) residual stress within limb bud epithelium and mesenchyme, (ii) mechanical constraint on mesenchymal tissue morphology by epithelial tissue, (iii) stress anisotropy and (iv) Young's modulus of epithelial tissue. These results elucidated the mechanical role of epithelial tissue in limb morphogenesis [Kawamura et al., in preparation].
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