| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
Polymorphisms in human leukocyte antigens (HLA) are associated strongly with a variety of immunological disorders including autoimmunity, infection, cancer, and adverse drug reactions. With an aim to develop a means to treat these diseases based on individual’s HLA genotypes, it would be essential to collect and integrate the knowledge on functional differences and commonality among diverse HLA allele products. One of the main functional diversity among HLA alleles are the binding specificity for peptides. In this study we developed a new method to analyze an interaction of HLA class II with peptides that would outperform currently available methodologies in terms of sensitivity and reproducibility and would be suitable for a large-scale analysis.
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