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Implementing real time estimation studies of emerging infectious disease epidemics

Research Project

Project/Area Number 16KT0130
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Mathematical Sciences in Search of New Cooperation
Research InstitutionHokkaido University

Principal Investigator

Nishiura Hiroshi  北海道大学, 医学研究院, 教授 (70432987)

Project Period (FY) 2016-07-19 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords数理モデル / 感染症 / 疫学 / 危機管理
Outline of Final Research Achievements

Infectious disease modeling has been successfully used in analyzing the epidemic data in real time and offering short term forecast. The present study aimed to establish a preparatory research response even in advance of an epidemic, focusing on methodological foundations including model building and feedback to empirical data collection. We had numerous chance to apply quantitative models to emerging and reemerging infectious disease epidemics including pneumonic plague in Madagascar, cholera in Yemen and diphtheria outbreak in Bangladesh. Building up the premodeling research response system, we excelled into case studies involving an analysis of various types of epidemic data.

Academic Significance and Societal Importance of the Research Achievements

本研究の一番の特徴は、研究計画に至る着想の時点からオペレーショナルな発想に基づいて詳細の予定が練られている点にある。そのため、研究成果が真に公衆衛生上で社会からの要求及び応用数理科学からの期待に応えることができるよう工夫されており、コミュニティ単位での感染症対策に貢献することが期待される。また、数理科学との協働に基づく実践的研究であるため、実効再生産数を利用した新たな流行対策の構築や致死率の定義など新しい数理的法則の発見やデータ収集方法の抜本的改善に繋がることも本研究の強みである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (31 results)

All 2019 2018 2017 2016

All Journal Article (24 results) (of which Int'l Joint Research: 14 results,  Peer Reviewed: 24 results,  Open Access: 22 results,  Acknowledgement Compliant: 4 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Exploring the human-animal interface of Ebola virus disease outbreaks2019

    • Author(s)
      Ponce Luis、1 Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA、Kinoshita Ryo、Nishiura Hiroshi、2 Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
    • Journal Title

      Mathematical Biosciences and Engineering

      Volume: 16 Issue: 4 Pages: 3130-3143

    • DOI

      10.3934/mbe.2019155

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Estimating the Asymptomatic Ratio of Norovirus Infection During Foodborne Outbreaks With Laboratory Testing in Japan2018

    • Author(s)
      Miura F, Matsuyama R, Nishiura H
    • Journal Title

      Journal of Epidemiology

      Volume: 28 Issue: 9 Pages: 382-387

    • DOI

      10.2188/jea.JE20170040

    • NAID

      130007481555

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2018-09-05
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modeling the elevated risk of yellow fever among travelers visiting Brazil, 20182018

    • Author(s)
      Sakamoto Yohei、Yamaguchi Takayuki、Yamamoto Nao、Nishiura Hiroshi
    • Journal Title

      Theoretical Biology and Medical Modelling

      Volume: 15 Issue: 1 Pages: 9-9

    • DOI

      10.1186/s12976-018-0081-1

    • NAID

      120006502507

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An investigation of a measles outbreak in Japan and Taiwan, China, March-May 20182018

    • Author(s)
      Shimizu Kazuki、Kinoshita Ryo、Yoshii Keita、Akhmetzhanov Andrei、Jung Sungmok、Lee Hyojung、Nishiura Hiroshi
    • Journal Title

      Western Pacific Surveillance and Response Journal

      Volume: 9 Issue: 3 Pages: 25-31

    • DOI

      10.5365/wpsar.2018.9.2.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Capturing the transmission dynamics of the 2009 Japanese pandemic influenza H1N1 in the presence of heterogeneous immunity2018

    • Author(s)
      Endo Akira、Ejima Keisuke、Nishiura Hiroshi
    • Journal Title

      Annals of Epidemiology

      Volume: 28 Issue: 5 Pages: 293-300.e1

    • DOI

      10.1016/j.annepidem.2018.02.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Real-time quantification of the next-generation matrix and age-dependent forecasting of pandemic influenza H1N1 2009 in Japan2018

    • Author(s)
      Ejima Keisuke、Nishiura Hiroshi
    • Journal Title

      Annals of Epidemiology

      Volume: 28 Issue: 5 Pages: 301-308

    • DOI

      10.1016/j.annepidem.2018.02.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Uncertainty and sensitivity analysis of the basic reproduction number of diphtheria: a case study of a Rohingya refugee camp in Bangladesh, November-December 2017.2018

    • Author(s)
      Matsuyama R, Akhmetzhanov AR, Endo A, Lee H, Yamaguchi T, Tsuzuki S, Nishiura H
    • Journal Title

      PeerJ

      Volume: - Pages: e4583-e4583

    • DOI

      10.7717/peerj.4583

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Household transmission of acute gastroenteritis during the winter season in Japan2018

    • Author(s)
      Matsuyama Ryota、Miura Fuminari、Tsuzuki Shinya、Nishiura Hiroshi
    • Journal Title

      Journal of International Medical Research

      Volume: 46 Issue: 7 Pages: 2866-2874

    • DOI

      10.1177/0300060518776451

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Measles control in a measles-eliminated country, Japan2018

    • Author(s)
      Kinoshita Ryo、Shimizu Kazuki、Nishiura Hiroshi
    • Journal Title

      Travel Medicine and Infectious Disease

      Volume: 25 Pages: 8-9

    • DOI

      10.1016/j.tmaid.2018.08.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Real Time Forecasting of Measles Using Generation-dependent Mathematical Model in Japan, 20182018

    • Author(s)
      Akhmetzhanov Andrei R.、Lee Hyojung、Jung Sung-mok、Kinoshita Ryo、Shimizu Kazuki、Yoshii Keita、Nishiura Hiroshi
    • Journal Title

      PLoS Currents

      Volume: 10 Pages: 1-6

    • DOI

      10.1371/currents.outbreaks.3cc277d133e2d6078912800748dbb492

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Forecasting the size and peak of cholera epidemic in Yemen, 20172018

    • Author(s)
      Nishiura H, Tsuzuki S, Asai Y
    • Journal Title

      Future Microbiology

      Volume: 13 Issue: 4 Pages: 399-402

    • DOI

      10.2217/fmb-2017-0244

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessing the Effectiveness and Cost-Benefit of Test-and-Vaccinate Policy for Supplementary Vaccination against Rubella with Limited Doses2018

    • Author(s)
      Saito MM, Ejima K, Kinoshita R, Nishiura H
    • Journal Title

      Int J Environ Res Public Health

      Volume: 15 Issue: 4 Pages: 572-572

    • DOI

      10.3390/ijerph15040572

    • NAID

      120006522670

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Role of Migration in Maintaining the Transmission of Avian Influenza in Waterfowl: A Multisite Multispecies Transmission Model along East Asian-Australian Flyway2018

    • Author(s)
      Akira Endo and Hiroshi Nishiura
    • Journal Title

      Canadian Journal of Infectious Diseases and Medical Microbiology

      Volume: 2018 Pages: 3420535-3420535

    • DOI

      10.1155/2018/3420535

    • NAID

      120006484262

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Joint estimation of the transmissibility and severity of Ebola virus disease in real time.2018

    • Author(s)
      Asai Y, Nishiura H.
    • Journal Title

      Journal of Biological Systems

      Volume: 25 Issue: 04 Pages: 587-603

    • DOI

      10.1142/s0218339017400022

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Infectious disease risks among refugees from North Korea2017

    • Author(s)
      Hiroshi Nishiura, Hyojung Lee, Baoyin Yuan, Akira Endo, Andrei R.Akhmetzhanov, GerardoChowell
    • Journal Title

      International Journal of Infectious Diseases

      Volume: 66 Pages: 22-25

    • DOI

      10.1016/j.ijid.2017.10.021

    • NAID

      120006406687

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unrecognized Subclinical Infection with Tickborne Encephalitis Virus, Japan2017

    • Author(s)
      Kentaro Yoshii, Reiji Kojima, and Hiroshi Nishiura
    • Journal Title

      Emerging Infectious Diseases

      Volume: 23 Issue: 10 Pages: 1753-1754

    • DOI

      10.3201/eid2310.170918

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamics of the pneumonic plague epidemic in Madagascar, August to October 20172017

    • Author(s)
      Tsuzuki S, Lee H, Miura F, Chan YH, Jung S, Akhmetzhanov AR, Nishiura H.
    • Journal Title

      Eurosurveillance

      Volume: 22 Issue: 46 Pages: 17-00710

    • DOI

      10.2807/1560-7917.es.2017.22.46.17-00710

    • NAID

      120006380365

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transmission dynamics of cholera in Yemen, 2017: a real time forecasting2017

    • Author(s)
      Nishiura H, Tsuzuki S, Yuan B, Yamaguchi T, Asai Y
    • Journal Title

      Theoretical Biology and Medical Modelling

      Volume: 14 Issue: 1 Pages: 14-14

    • DOI

      10.1186/s12976-017-0061-x

    • NAID

      120006352210

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recrudescence of Ebola virus disease outbreak in West Africa, 2014-20162017

    • Author(s)
      Lee H, Nishiura H
    • Journal Title

      International Journal of Infectious Diseases

      Volume: 64 Pages: 90-92

    • DOI

      10.1016/j.ijid.2017.09.013

    • NAID

      120006373734

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Test-and-treat approach to HIV/AIDS: A primer for mathematical modeling.2017

    • Author(s)
      Nah K, Nishiura H, Tsuchiya N, Asai Y, Imamura A
    • Journal Title

      Theoretical Biology and Medical Modelling

      Volume: 14 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s12976-017-0062-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessing the transmission dynamics of measles in Japan, 2016.2017

    • Author(s)
      Nishiura H, Mizumoto K, Asai Y.
    • Journal Title

      Epidemics

      Volume: 未定 Pages: 67-72

    • DOI

      10.1016/j.epidem.2017.03.005

    • NAID

      120006373735

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The transmissibility of noroviruses: Statistical modeling of outbreak events with known route of transmission in Japan2017

    • Author(s)
      Matsuyama R, Miura F, Nishiura H
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 3 Pages: e0173996-e0173996

    • DOI

      10.1371/journal.pone.0173996

    • NAID

      120006219940

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis.2016

    • Author(s)
      Matsuyama R, Nishiura H, Kutsuna S, Hayakawa K, Ohmagari N.
    • Journal Title

      BMC Public Health

      Volume: 16 Pages: 1203-1203

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Estimating the subcritical transmissibility of the Zika outbreak in the State of Florida, USA, 2016.2016

    • Author(s)
      Dinh L, Chowell G, Mizumoto K, Nishiura H.
    • Journal Title

      Theoretical Biology and Medical Modelling

      Volume: 13 Issue: 1 Pages: 20-20

    • DOI

      10.1186/s12976-016-0046-1

    • NAID

      120005946860

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Ascertaining the End of Ebola Virus2018

    • Author(s)
      Hiroshi Nishiura
    • Organizer
      The 12th AIMS Conference on Dynamical Systems Differential Equations and Applications
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metapopulation epidemic model fitted to spatiotemporal spread of rubella in Japan, 2012-132018

    • Author(s)
      Hiroshi Nishiura
    • Organizer
      The Society for Mathematical Biology & the Japanese Society for Mathematical Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2つの方法を利用した風疹ワクチン接種の優先的接種のモデル化2016

    • Author(s)
      西浦博
    • Organizer
      RIMS研究集会第13回「生物数学の理論とその応用」
    • Place of Presentation
      京都大学数理解析研究所(京都府京都市)
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Real time modeling: two studies2016

    • Author(s)
      西浦博
    • Organizer
      第75回日本公衆衛生学会総会 自由集会:公衆衛生学と感染症数理モデルに関する研究会,
    • Place of Presentation
      グランフロント大阪(大阪府大阪市)
    • Year and Date
      2016-10-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 世界におけるウイルス感染症の広がりを予測する2016

    • Author(s)
      西浦博
    • Organizer
      日本ウイルス学会学術集会市民公開講座
    • Place of Presentation
      北海道大学クラーク会館(北海道札幌市)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ジカウイルスの国際伝播に関する予測モデルの開発2016

    • Author(s)
      西浦博
    • Organizer
      日本応用数理学会学術総会2016年会
    • Place of Presentation
      北九州会議場(福岡県北九州市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Mathematical modeling of MERS using epidemiological and genomic data2016

    • Author(s)
      Hiroshi Nishiura
    • Organizer
      Japanese Society for Mathematical Biology
    • Place of Presentation
      九州大学伊都キャンパス(福岡県福岡市)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report

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Published: 2016-07-20   Modified: 2023-03-08  

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