| Budget Amount *help |
¥442,780,000 (Direct Cost: ¥340,600,000、Indirect Cost: ¥102,180,000)
Fiscal Year 2009: ¥90,220,000 (Direct Cost: ¥69,400,000、Indirect Cost: ¥20,820,000)
Fiscal Year 2008: ¥90,220,000 (Direct Cost: ¥69,400,000、Indirect Cost: ¥20,820,000)
Fiscal Year 2007: ¥90,220,000 (Direct Cost: ¥69,400,000、Indirect Cost: ¥20,820,000)
Fiscal Year 2006: ¥81,900,000 (Direct Cost: ¥63,000,000、Indirect Cost: ¥18,900,000)
Fiscal Year 2005: ¥90,220,000 (Direct Cost: ¥69,400,000、Indirect Cost: ¥20,820,000)
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| Research Abstract |
We identified a type I-membrane protein that recognizes phosphatidylserine exposed on the cell surface of apoptotic cells, and found that there are specific gates in the phagocytes for the entry of apoptotic cells. In these gates, actin polymerized when the dead cells enter and it de polymerized as soon as they are inside of the phagocytes. We also found that if the DNA of apoptotic cells is not degraded in the phagocytes, the macrophages produce various cytokines that causes anemia and arthritis.
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