| Budget Amount *help |
¥225,810,000 (Direct Cost: ¥173,700,000、Indirect Cost: ¥52,110,000)
Fiscal Year 2007: ¥66,170,000 (Direct Cost: ¥50,900,000、Indirect Cost: ¥15,270,000)
Fiscal Year 2006: ¥69,810,000 (Direct Cost: ¥53,700,000、Indirect Cost: ¥16,110,000)
Fiscal Year 2005: ¥89,830,000 (Direct Cost: ¥69,100,000、Indirect Cost: ¥20,730,000)
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| Research Abstract |
We have obtained following results through this study.
1. GAGA factor FACT complex recruits chromatin remodeling complex PBAP to Pc/trx response elements, induces chromatin remodeling, and maintains expression of Hox genes.
2. GAGA factor-FACT complex binds to a GA repeat sequence downstream the white gene, induces chromatin remodeling, replaces histone H3 by its variant H3.3, and maintains white gene expression by counteracting the heterochromatin spreading.
3. Transcription of non-coding RNA through Pc/trx response element regulates Hox gene expression.
4. Supercoiling factor is recruited to chromatin acetylated at histone H4 K16 by MOF, and contributes dosage compensation of X chromosome through counteracting with ISWI.
5. Ash1 knock-out mice are homozygous viable but show homeotic transformation of the back-one. SPT16 knock-out mice are embryonic lethal in homozygotes. Its heterozygotes show a deviation in the levels of IgG sublasses.
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