Analyses of Molecular Assembly and Diversity of Proteasomes

• Project/Area Number: 17002019
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Metropolitan Organization for Medical Research
• Principal Investigator: TANAKA Keiji Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員 (10108871)
• Co-Investigator(Kenkyū-buntansha): MURATA Shigeo 東京大学, 大学院・薬学系研究科, 教授 (20344070)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥642,850,000 (Direct Cost: ¥494,500,000、Indirect Cost: ¥148,350,000); Fiscal Year 2009: ¥120,770,000 (Direct Cost: ¥92,900,000、Indirect Cost: ¥27,870,000); Fiscal Year 2008: ¥120,770,000 (Direct Cost: ¥92,900,000、Indirect Cost: ¥27,870,000); Fiscal Year 2007: ¥132,470,000 (Direct Cost: ¥101,900,000、Indirect Cost: ¥30,570,000); Fiscal Year 2006: ¥138,320,000 (Direct Cost: ¥106,400,000、Indirect Cost: ¥31,920,000); Fiscal Year 2005: ¥130,520,000 (Direct Cost: ¥100,400,000、Indirect Cost: ¥30,120,000)
• Keywords: ユビキチン / プロテアソーム / オートファジー / 蛋白質分解 / 分子集合 / 分子多様性 / ガン / 神経変性疾患 / ATP依存性プロテアーゼ / ユビキチンリガーゼ / 胸腺特異的プロテアソーム / タンパク質分解 / ATP

Research Abstract

The proteasome is an unusually large cellular apparatus that selectively degrades unnecessary proteins, which must be eliminated from the cells. We defined the molecular mechanisms underling proteasome assembly by the findings of a set of proteasome-dedicated molecular chaperones that assist the correct formation of the proteasome. In addition, we established the new concept on the diversity of the proteasome. Previously, we discovered the "immunoproteasome", which emphasized the specialized functions in immune responses. Lately, we also identified another unique "thymoproteasome", which is expressed exclusively in the thymus. We found that thymoproteasome-deficient mice displayed defective thymic development of CD8+T cells, suggesting a key role for thymoproteasome in the development of the MHC class I-restricted CD8+T cell repertoire during thymic positive selection.

Research Products

• [Journal Article] An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis. (2009)
  • Author(s): Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., Tanaka, K.
  • Journal Title: Cell 137 Pages: 549-559
• [Journal Article] Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle. (2009)
  • Author(s): Saeki, Y., Toh-e, A., Kudo, T., Kawamura, H., Tanaka, K.
  • Journal Title: Cell 137 Pages: 900-913
• [Journal Article] Assembly pathway of the mammalian proteasome base subcomplex is mediated by multiple specific chaperones. (2009)
  • Author(s): Kaneko, T., Hamazaki, J., Iemura, S., Sasaki, K., Furuyama, K., Natsume, T., Tanaka, K., Murata, S.
  • Journal Title: Cell 137 Pages: 914-925
• [Journal Article] Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome. (2009)
  • Author(s): Saeki, Y., Kudo, T., Sone, T., Kikuchi, Y., Yokosawa, H., Toh-e, A., Tanaka, K.
  • Journal Title: EMBO J 28 Pages: 359-371
• [Journal Article] Molecular mechanisms of proteasome assembly. (2009)
  • Author(s): Murata, S., Yashiroda, H., Tanaka, K.
  • Journal Title: Nat Rev Mol Cell Biol 10 Pages: 104-115
• [Journal Article] The proteasome: Overview of structure and functions. (2009)
  • Author(s): Tanaka, K.
  • Journal Title: Proc Jpn Acad Ser B85 Pages: 12-36
  • NAID: 130000093918
• [Journal Article] Linear ubiquitination of NEMO triggers NF-κB activation. (2009)
  • Author(s): Tokunaga, T., Sakata, S., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Murata, S., Yamaoka, S., Takao, T., Tanaka, K., and Iwai K.
  • Journal Title: Nature Cell Biol. 11 Pages: 123-132
  • Peer Reviewed
• [Journal Article] Genetic evidence linking age-dependent attenuation of the 26S proteasome with aging process. (2009)
  • Author(s): Tonoki, A., Kuranaga, E., Tomioka, T., Hamazaki, J., Murata, S., Tanaka, K., and Miura. M.
  • Journal Title: Mol Cell Biol. 29 Pages: 1095-1106
  • Peer Reviewed
• [Journal Article] Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome. (2009)
  • Author(s): Saeki, Y., Kudo, T., Sone, T., Kikuchi, Y., Yokosawa, H., Toh-e, A., and Tanaka, K.
  • Journal Title: EMBO J. 28 Pages: 359-371
  • Peer Reviewed
• [Journal Article] An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis. (2009)
  • Author(s): Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., and Tanaka, K.
  • Journal Title: Cell in press (May 1^<st>).
  • Peer Reviewed
• [Journal Article] Autophagy regulates lipid metabolism. (2009)
  • Author(s): Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, AM, and Czaja, M.
  • Journal Title: Nature 458 Pages: 1131-1135
  • Peer Reviewed
• [Journal Article] Exclusive expression of proteasome subunit β5t in the human thymic cortex. (2009)
  • Author(s): Tomaru, U., Ishizu, A., Murata, S., Miyakate, Y., Suzuki, S., Takahashi, S., Kazamaki, T., Ohara, J., Baba, T., Iwasaki, S., Fugo, K., Otsuka, N., Tanaka, K., and Kasahara, M.
  • Journal Title: Blood in press
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of proteasome assembly. (2009)
  • Author(s): Murata, S., Yashiroda, H., and Tanaka, K.
  • Journal Title: Nat Rev Mol Cell Biol 10 Pages: 104-115
  • Peer Reviewed
• [Journal Article] The proteasome : Overview of structure and functions. (2009)
  • Author(s): Tanaka, K.
  • Journal Title: Proc. Jpn. Acad. Ser B Phys Biol Sci. 85 Pages: 12-36
  • NAID: 130000093918
  • Peer Reviewed
• [Journal Article] Thymic environments of T-cell repertoire formation. (2009)
  • Author(s): Nitta, T., Murata, S., Ueno, T., Tanaka, K., and Takahama, Y.
  • Journal Title: Adv Immunol in press
  • Peer Reviewed
• [Journal Article] The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases. (2009)
  • Author(s): Yue, Z., Friedman, L., Komatsu, M., and Tanaka, K.
  • Journal Title: Biochem Biophys Acta - Mol Cell Res. in press.
  • Peer Reviewed
• [Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes. (2008)
  • Author(s): Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama, T., Hayashi, H., Kishimoto, T., Kasahara, M., Kurimoto, E., Sakata, E., Suzuki, A., Hirano, Y., Murata, S., Kato, K., Yamane, T., Tanaka, K.
  • Journal Title: Nat Struct Mol Biol 15 Pages: 228-236
• [Journal Article] -ring assembly pathway of the mammalian 20S proteasome. (2008)
  • Author(s): Hirano, Y., Kaneko, T., Okamoto, K., Bai, M., Yashiroda, H., Furuyama, K., Kato, K., Tanaka, K., Murata, S.
  • Journal Title: EMBO J 27 Pages: 2204-2213
• [Journal Article] Mammalian 26S proteasomes remain intact during protein degradation. (2008)
  • Author(s): Kriegenburg, F., Seeger, M., Saeki, Y., Tanaka, K., Lauridsen, A-M.B., Hartmann-Petersen, R., Hendil, K.B.
  • Journal Title: Cell 135 Pages: 355-365
• [Journal Article] Thymoproteasome: probable role in generating positively selecting peptides. (2008)
  • Author(s): Murata, S., Takahama, Y., Tanaka, K.
  • Journal Title: Curr Opini Immunol 20 Pages: 192-196
• [Journal Article] Cell biology: two hands for degradation. (2008)
  • Author(s): Saeki, Y., Tanaka, K.
  • Journal Title: Nature 453 Pages: 460-461
• [Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes. (2008)
  • Author(s): Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama, T., Hayashi, H., Kishimoto, T., Kasahara, M., Kurimoto, E., Sakata, E., Suzuki, A., Hirano. Y., Murata, S., Kato, K., Yamane, T., and Tanaka, K.
  • Journal Title: Nature Struct. Mol. Biol. 15 Pages: 228-236
  • Peer Reviewed
• [Journal Article] A novel ubiquitin ligase involved in p57^<Kip2> proteolysis regulates osteoblast cell differentiation. (2008)
  • Author(s): Kim, M., Nakamoto, T., Nishimori, S., Tanaka, K., and Chiba, T.
  • Journal Title: EMBO Rep. 9 Pages: 878-884
  • Peer Reviewed
• [Journal Article] Dissecting β-ring assembly pathway of the mammalian 20S proteasome. (2008)
  • Author(s): Hirano, Y., Kaneko, T., Okamoto, K., Bai, M., Yashiroda, H., Furuyama, K., Kato, K., Tanaka, K., and Murata, S.
  • Journal Title: EMBO J. 27 Pages: 2204-2213
  • Peer Reviewed
• [Journal Article] Mammalian 26S proteaspmes remain intact during protein degradation. (2008)
  • Author(s): Kriegenburg, F., Seeger, M., Saeki, Y., Tanaka, K., Lauridsen, A-M. B., Hartmann-Petersen, R., and Hendil, K. B.
  • Journal Title: Cell 135 Pages: 355-365
  • Peer Reviewed
• [Journal Article] Autophagy in pancreatic beta cells is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. (2008)
  • Author(s): Ebato, C., Uchida, T., Arakawa, M., Komatsu, M., Ueno, T., Azumal, K., Hirose, T., Tanaka, K., Kominami, E., Kawamori, R., Fujitani, Y., and Watada, H.
  • Journal Title: Cell Metab. 8 Pages: 325-332
  • Peer Reviewed
• [Journal Article] Essential role of Macroautophagy in Pancreatic β-Cell Survival and Proliferation. (2008)
  • Author(s): Jung, HS., Chung, KW., Kim, JW., Kim, J., Komatsu, M., Tanaka, K., Nguyen, YH., Kang, TM., Jeong, YT., Han, MS., Lee, MK., Kim, KW., and Lee, MS.
  • Journal Title: Cell Metab. 8 Pages: 318-324
  • Peer Reviewed
• [Journal Article] The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. (2008)
  • Author(s): Sou, Y., Waguri, S., Iwata, J., Ueno, T., Fujimura, T., Hara, T., Sawada, N., Yamada, A., Mizushima, N., Uchiyama, Y., Kominami, E., Tanaka, K., and Komatsu, M.
  • Journal Title: Mol Biol Cell 19 Pages: 4762-4775
  • Peer Reviewed
• [Journal Article] Thymoproteasome : probable role in generating positively selecting peptides. (2008)
  • Author(s): Murata, S., Takahama, Y., and Tanaka, K.
  • Journal Title: Curr Opini Immunol 20 Pages: 192-196
  • Peer Reviewed
• [Journal Article] Modest cortex and promiscuous medulla for thymic repertoire formation. (2008)
  • Author(s): Takahama, Y., Tanaka, K., and Murata, S.,
  • Journal Title: Trends Immunol 29 Pages: 251-155
  • Peer Reviewed
• [Journal Article] Cell biology : two hands for degradation. (2008)
  • Author(s): Saeki, Y. and Tanaka, K.
  • Journal Title: Nature (News and Views) 453 Pages: 460-461
  • Peer Reviewed
• [Journal Article] Selective turnover of p62/a170/Sqstm1 by autophagy. (2008)
  • Author(s): Ichimura, Y., Kominami, E., Tanaka, K., and Komatsu, M.
  • Journal Title: Autophagy 4 Pages: 1063-1066
  • Peer Reviewed
• [Journal Article] Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury (2008)
  • Author(s): Koike, M., et. al.
  • Journal Title: Am.J.Pathol 172 Pages: 454-469
  • Peer Reviewed
• [Journal Article] Muscle RING-Finger protein MuRFl as a connector of muscle energy metabolism and protein synthesis (2008)
  • Author(s): Koyama, S., et. al.
  • Journal Title: J.Mol.Biol. 376 Pages: 1224-1236
  • Peer Reviewed
• [Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes (2008)
  • Author(s): Yashiroda, H., et. al.
  • Journal Title: Nature Struct.Mol.Biol 15 Pages: 228-236
  • Peer Reviewed
• [Journal Article] A novel small-molecule inhibitor of NF-κB signaling (2008)
  • Author(s): Nakajima, H., et. al.
  • Journal Title: Biochem.Biophys.Res.Commun 368 Pages: 1007-1013
  • Peer Reviewed
• [Journal Article] Comprehensive proteomics analysis of autophagy-deficient mouse liver.Autophagy deficiency is associated with overexpression of stress-related proteins (2008)
  • Author(s): Matsumoto, N., et. al.
  • Journal Title: Biochem.Biophys.Res.Commun 68 Pages: 1007-1013
  • Peer Reviewed
• [Journal Article] Gp78 cooperates with RMAl in ER-associated degradation of CFTRΔF508 (2008)
  • Author(s): Morito, Hirao, K., et. al.
  • Journal Title: Mol Biol Cell 19 Pages: 1328-1336
  • Peer Reviewed
• [Journal Article] Structural basis for ubiquitin-fold modifier 1(ufm1) processing by ufm1 speicific protease,UFSP (2008)
  • Author(s): Ha BH, et. al.
  • Journal Title: J Biol Chem 283 Pages: 14893-14900
  • Peer Reviewed
• [Journal Article] c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130 (2008)
  • Author(s): Tanaka, Y., et. al.
  • Journal Title: Mol.Cell.Biol 28 Pages: 4805-4818
  • Peer Reviewed
• [Journal Article] Allele-selective effect of PA28 in MHC class I antigen processing (2008)
  • Author(s): Yamano, T., et. al.
  • Journal Title: J.Immunol 181 Pages: 1655-1664
  • Peer Reviewed
• [Journal Article] Dissecting β-ring assembly pathway of the mammalian 20S Proteasome (2008)
  • Author(s): Hirano, Y., et. al.
  • Journal Title: EMBO J 27 Pages: 2204-2213
  • Peer Reviewed
• [Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. (2007)
  • Author(s): Komatsu, M., Waguri, S., Koike, M., Sou, Y., Ueno, T., Hara, T., Mizushima, N., Iwata, J., Ezaki, J., Murata, S., Hamazaki, J., Nishito, Y., Iemura, S., Natsume, N., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., Tanaka, K.
  • Journal Title: Cell 131 Pages: 1149-1163
• [Journal Article] Regulation of CD8+ T cell development by thymus-specific proteasomes. (2007)
  • Author(s): Murata, S., Sasaki, K., Kishimoto, T., Niwa, S., Hayashi, H., Takahama, Y., Tanaka, K.
  • Journal Title: Science 316 Pages: 1349-1353
• [Journal Article] Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase. (2007)
  • Author(s): Mizushima, T., Yoshida, Y., Kumanomidou, T., Hasegawa, Y., Suzuki, A., Yamane, T., Tanaka, K.
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 5777-5781
• [Journal Article] Unlocking the proteasome door. (2007)
  • Author(s): Saeki, Y, Tanaka, K.
  • Journal Title: Mol Cell 27 Pages: 865-867
• [Journal Article] Cytoplasmic destruction of tumor suppressor gene p53 by the endoplasmic reticulum-resident ubiquitin ligase "Synoviolin" (2007)
  • Author(s): Yamasaki, S., et. al.
  • Journal Title: EMBOJ 26 Pages: 113-122
  • Peer Reviewed
• [Journal Article] Ihvolvement of PA28□-Dependent Pathway in Insulin Resistance Induced by Hepatitis C Vuus Core Protein 3 (2007)
  • Author(s): Miyamoto, H., et. al.
  • Journal Title: J.Virol 81 Pages: 1727-1735
  • Peer Reviewed
• [Journal Article] The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome (2007)
  • Author(s): Isono, E., et. al.
  • Journal Title: Mol Biol Cell 18 Pages: 569-580
  • Peer Reviewed
• [Journal Article] Cdtical role of PA28□ in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis (2007)
  • Author(s): Moriishi, K., et. al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 104 Pages: 1661-1666
  • Peer Reviewed
• [Journal Article] Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-reulation of cullin-based E3 liase activity (2007)
  • Author(s): Sakata, E., et. al.
  • Journal Title: Nature Struct.Mol.Biol 14 Pages: 167-168
  • Peer Reviewed
• [Journal Article] Two novel ubiquitin-fold modifier 1(Ufm1)-specific proteases, UfSP1 and UfSP2 (2007)
  • Author(s): Kang, S.H., et. al.
  • Journal Title: J Biol Chem 282 Pages: 5256-5262
  • Peer Reviewed
• [Journal Article] A Neural-specific F-box protein Fbsl functions as a chaperone suppressing glycoprotein aggregation (2007)
  • Author(s): Yoshida, Y., et. al.
  • Journal Title: J.Biol.Chem 282 Pages: 7137-7144
  • Peer Reviewed
• [Journal Article] TBP-interacting protein 120b(TIP120B)/cullin-associated and neddylation-dissociated 2(CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiaton (2007)
  • Author(s): Shiraishi, S., et. al.
  • Journal Title: J Biol Chem 282 Pages: 9017-9028
  • Peer Reviewed
• [Journal Article] Structural basis for selection of glycosylated substrate by SCF^<Fbsl> ubiquitin ligase (2007)
  • Author(s): Mizushima, T., et. al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 104 Pages: 5777-5781
  • Peer Reviewed
• [Journal Article] Regulation of CD8^+ T cell development by thymus-specific proteasomes (2007)
  • Author(s): Murata, S., et. al.
  • Journal Title: Science 316 Pages: 1349-1353
  • Peer Reviewed
• [Journal Article] Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration (2007)
  • Author(s): Komatsu M., et. al.
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 14489-14494
  • Peer Reviewed
• [Journal Article] SCRAPPER-dependent ubiquitination of active zone protein RIMl regulates synaptic vesicle release (2007)
  • Author(s): Yao, I., et. al.
  • Journal Title: Cell 130 Pages: 943-957
  • Peer Reviewed
• [Journal Article] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development (2007)
  • Author(s): Hamazaki J., et. al.
  • Journal Title: Mol.Cell.Biol 27 Pages: 6629-6638
  • Peer Reviewed
• [Journal Article] Fbs1 protects the malfolded glycoproteins from the attack of peptide:N-glycanase (2007)
  • Author(s): Yamaguchi, Y., et. al.
  • Journal Title: Biochem.Biophys.Res.Commun 362 Pages: 712-716
  • Peer Reviewed
• [Journal Article] Homeostatic levels of p62 control cytoplaslnic inclusion body formation in autopha-deficient mice (2007)
  • Author(s): Komatsu, M., et. al.
  • Journal Title: Cell 131 Pages: 1149-1163
  • Peer Reviewed
• [Journal Article] Crystal structure of Ufc1,the Ufm1-conjugating enzyme (2007)
  • Author(s): Mizushima T., et.al.
  • Journal Title: Biochem.Biophys.Res.Common 362 Pages: 1079-1084
  • Peer Reviewed
• [Journal Article] Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis (2007)
  • Author(s): Sanjuan, M.A., et. al.
  • Journal Title: Nature 450 Pages: 1253-1257
  • Peer Reviewed
• [Journal Article] Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. (2006)
  • Author(s): Hirano, Y., Hayashi, H., Iemura, S., Hendil, K.B., Niwa, S., Kishimoto, T., Natsume, T., Kasahara, M., Tanaka, K., Murata, S.
  • Journal Title: Mol Cell 24 Pages: 977-984
• [Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. (2006)
  • Author(s): Hamazaki, J., Iemura, S., Natsume, T., Yashiroda, H., Tanaka, K., Murata, S.
  • Journal Title: EMBO J. 25 Pages: 4524-4536
• [Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration. (2006)
  • Author(s): Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K.
  • Journal Title: Nature 441 Pages: 880-884
• [Journal Article] 14-3-3h is a novel regulator of parkin ubiquitin-ligase (2006)
  • Author(s): Sato, S., Chiba, T., Sakata, E., Kato, K., Mizuno, Y., Hattori, N., Tanaka, K.
  • Journal Title: EMBO J. 25 Pages: 211-221
• [Journal Article] Diverse effects of pathogenic mutations of Parkin that catalyzes multiple mono-ubiquitylation in vitro (2006)
  • Author(s): Matsuda, N., Kitami, T., Suzuki, T., Mizuno, Y., Hattori, N., Tanaka, K
  • Journal Title: J. Biol. Chem. 281 Pages: 3204-3209
• [Journal Article] Loss of autophagy in the central nervous system causes neurodegeneration (2006)
  • Author(s): Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K.
  • Journal Title: Nature 441 Pages: 880-884
• [Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes (2006)
  • Author(s): Hamazaki, J., Iemura, S., Natsume, T., Yashiroda, H., Tanaka, K., Murata, S.
  • Journal Title: EMBO J. 25 Pages: 4524-4536
• [Journal Article] Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes (2006)
  • Author(s): Hirano, Hayashi, H., Iemura, S., Hendil, K.B., Niwa, S., Kishimoto, T., Natsume, T., Kasahara, M., Tanaka, K., Murata, S.
  • Journal Title: Mol Cell 24 Pages: 977-984
• [Journal Article] SUMO-specific protease UlpA positively regulates p53 tumor suppressor by promoting self-ubiquitination of Mdm2 (2006)
  • Author(s): Moon Hee Lee, M.H., Lee, E.J., Choi, S., J., Lee, S.W., Chung, S.S., Seol, J.H., Baek, S.H., Kim, K.L., Chiba, T., Tanaka, K., Bang, O.S., Chung, C.H.
  • Journal Title: Nature Cell Biol. 8 Pages: 1424-1431
• [Journal Article] 14-3-3h is a novel regulator of parkin ubiquitin-ligase (2006)
  • Author(s): Sato, S.
  • Journal Title: EMBO J. 25 Pages: 211-221
• [Journal Article] Diverse effects of pathogenic mutations of Parkin that catalyzes multiple mono-ubiquitylation in vitro. (2006)
  • Author(s): Matsuda, N.
  • Journal Title: J.Biol.Chem. 281 Pages: 3204-3209
• [Journal Article] The6Crystal Structure of Human Atg4b, a Processing and Deconjugating Enzyme for Autophagosome-forming Modifiers (2006)
  • Author(s): Kumanomidou, T.
  • Journal Title: J.Mol.Biol. 355 Pages: 612-618
• [Journal Article] Excess peroxisomes are degraded by autophagic machinery in mammals (2006)
  • Author(s): Iwata, J.
  • Journal Title: J.Biol.Chem. 281 Pages: 4035-4041
• [Journal Article] A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes (2005)
  • Author(s): Hirano, Y., Hendil, K.B., Yashiroda, H., Iemura, S., Nagane, R., Hioki, Y., Natsume, T., Tanaka, K., Murata, S.
  • Journal Title: Nature 437 Pages: 1381-1385
• [Journal Article] Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. (2005)
  • Author(s): Komatsu, M., Waguri, S., Ueno, T., Murata, S., Tanida, I., Ezaki, E., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., Chiba, T.
  • Journal Title: J. Cell Biol 169 Pages: 425-434
• [Journal Article] DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex. (2005)
  • Author(s): Matsuda, N.
  • Journal Title: DNA Repair 4 Pages: 537-545
• [Journal Article] Glycoprotein-specific ubiquitin-ligases recognize N-glycans in unfolded (2005)
  • Author(s): Yoshida, Y.
  • Journal Title: EMBO Rep. 6 Pages: 239-244
• [Journal Article] Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes (2005)
  • Author(s): Jana, N.R.
  • Journal Title: J Biol Chem. 280 Pages: 11635-11640
• [Journal Article] UV induced ubiquitylation of XPC protein mediated by UV DDB-ubiquitin ligase complex (2005)
  • Author(s): Sugasawa, K.
  • Journal Title: Cell 121 Pages: 387-400
• [Journal Article] Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice (2005)
  • Author(s): Komatsu, M.
  • Journal Title: J.Cell Biol. 169 Pages: 425-434
• [Journal Article] Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells (2005)
  • Author(s): Machida, Y.
  • Journal Title: Biochem Biophys Res Commun. 332 Pages: 233-240
• [Journal Article] Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex. (2005)
  • Author(s): Megumi, Y.
  • Journal Title: Genes Cells 10 Pages: 679-691
• [Journal Article] In vivo evidence of CHIP up-regulation attenuating tau aggregation. (2005)
  • Author(s): Sahara, N.
  • Journal Title: J Neurochem. 194 Pages: 1254-1263
• [Journal Article] A novel heterodimeric complex that promotes the assembly of mammalian 20S proteasomes (2005)
  • Author(s): Hirano, Y.
  • Journal Title: Nature 437 Pages: 1381-1385
• [Journal Article] A novel ubiquitin ligase involved in p57^<Kip2> proteolysis regulates osteoblast cell differentiation
  • Author(s): Kim, M., et. al.
  • Journal Title: EMBO Rep (in press)
  • Peer Reviewed
• [Journal Article] Structural basis for sorting mechanism of p62 in selective autophagy
  • Author(s): Ichimura Y., et. al.
  • Journal Title: J Biol Chem (In press)
  • Peer Reviewed
• [Journal Article] Mammalian 26S proteasomes remain intact during protein degradation
  • Author(s): Kriegenburg, F., et. al.
  • Journal Title: Cell (In press)
  • Peer Reviewed
• [Journal Article] Autophagy in pancreatic beta cells is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
  • Author(s): Ebato, C., et. al.
  • Journal Title: Cell Metab (In press)
  • Peer Reviewed
• [Journal Article] Essential role of Macroautophagy in Pancreatic β-Cell Survival and Proliferation
  • Author(s): Jung, HS., et. al.
  • Journal Title: Cell Metab (In press)
  • Peer Reviewed
• [Journal Article] The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice
  • Author(s): Sou, Y., et. al.
  • Journal Title: Mol Biol Cell (In press)
  • Peer Reviewed
• [Journal Article] Hsp90 mediated assembly of the 26S proteasome is involved in MHC class I antigen processing
  • Author(s): Yamano T., et. al.
  • Journal Title: J.Biol.Chem (In press)
  • Peer Reviewed
• [Presentation] プロテアソーム研究の過去・現在・未来"予期しなかった免疫との出会い" (2008)
  • Author(s): 田中啓二
  • Organizer: 免疫サマースクール2008-免疫まるかじり
  • Place of Presentation: 南淡路ロイヤルホテル(淡路)
  • Year and Date: 2008-08-24
• [Presentation] Protein Degradation and Neuro-degenerative Diseases. (2008)
  • Author(s): 田中啓二
  • Organizer: Neuroscience 2008第31回日本神経科学大会. 特別講演。
  • Place of Presentation: 東京フォーラム)東京.
  • Year and Date: 2008-07-10
• [Presentation] Protein Degradation and Neuro-degenerative Diseases. (2008)
  • Author(s): 田中啓二
  • Organizer: Neuroscience 2008 第31回日本神経科学大会.特別講演
  • Place of Presentation: (東京フォーラム)東京
  • Year and Date: 2008-07-10
• [Presentation] Molecular Assembly and Dicersity of Proteasomes. (2008)
  • Author(s): Keiji Tanaka
  • Organizer: Max-Planck-Institute of Biochemistry
  • Place of Presentation: Martinsried, Germany
  • Year and Date: 2008-07-02
• [Presentation] The Novel Thymoproteasome Regulates Development of CD8+ T Cells. (2008)
  • Author(s): Keiji Tanaka
  • Organizer: 33rd FEBS Congress & 11th IUBMB Conference(Symposium on the ubiquitin-proteasome system)Peace and Friendship Stadium
  • Place of Presentation: Athens, Greece.
  • Year and Date: 2008-06-30
• [Presentation] The Novel Thymoproteasome Regulates Development of CD8^+ T Cells. (2008)
  • Author(s): Keiji Tanaka
  • Organizer: 33^<rd> FEBS Congress & 11^<th> IUBMB Conference (Symposium on the ubiquitin-proteasome system)
  • Place of Presentation: Peace and Friendship Stadium, Athens, Greece
  • Year and Date: 2008-06-30
• [Presentation] プロテアソームの分子集合機構の解明・どのように巨大で複雑な複合体は形成されるか?ターゲット蛋白研究プログラムシンポジウム(19年度文部科学省) (2008)
  • Author(s): 田中啓二
  • Organizer: 東京国際フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2008-02-12
• [Presentation] Unexpected encounter with immunity during my proteasome study. (2008)
  • Author(s): Keiji Tanaka
  • Organizer: Japan-German Immunology Seminar 2008:Immune Regulation in Health and Disease.
  • Place of Presentation: Fukuoka, Japan.
• [Presentation] Unexpected encounter with immunity during my proteasome study (2008)
  • Author(s): Keiji Tanaka
  • Organizer: Japan-German Immunology Seminar 2008 : Immune Regulation in Health and Disease
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Role of p62/SQSTM1 degradation by autophagy in cytoplasmic inclusion formation (2008)
  • Author(s): Masaaki Komatsu
  • Organizer: 3th GRC ALTTOPHAGY IN STRESS, DEVELOPMENT AND DISEASE
  • Place of Presentation: Ventura,CA,USA
• [Presentation] 蛋白質の輪廻転生・プロテアソームとオートファジーの世界 (2007)
  • Author(s): 田中 啓二
  • Organizer: 鹿児島大学生埋化学セミナー
  • Place of Presentation: 鹿児島
  • Year and Date: 2007-12-21
• [Presentation] ユビキチンの動態を制御する因子(Rfu1)の機能解析 (2007)
  • Author(s): 木村 洋子, 他
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] Regulation of positive selection of CD8 T cells by thymus-specific proteasomes (2007)
  • Author(s): 村田 茂穂, 他
  • Organizer: BMB2007(第30回日本分子生物学会, 第80回日本生化学会合同年会)
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] 平成19年度日本生化学会奨励賞受賞講演「プロテアソームによる適応免疫システム制御に関する研究」 (2007)
  • Author(s): 村田 茂穂
  • Organizer: BMB2007(第30回日本分子生物学会, 第80回日本生化学会合同年会)
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] The role of Atg8 conjugation system in mice (2007)
  • Author(s): Yu-shin Sou, et. al.
  • Organizer: BMB2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] 選択的オートファジLと封入体形成 (2007)
  • Author(s): 小松 雅明, 他
  • Organizer: BMB2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] 平成18年度生化学会奨励賞受賞講演 (2007)
  • Author(s): 小松 雅明
  • Organizer: BMB2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] 私のプロテアソーム研究-黎明期から成長期を辿って- (2007)
  • Author(s): 田中 啓二
  • Organizer: BMB2007マスターズレクチャー
  • Place of Presentation: 東京
  • Year and Date: 2007-12-12
• [Presentation] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse develovment (2007)
  • Author(s): 濱崎 純, 他
  • Organizer: 第30回日本分子生物学会年会、No.4P-0634
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] オートファジーによる制御 (2007)
  • Author(s): 田中 啓二
  • Organizer: 第2回臨床ストレス応答学会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-01
• [Presentation] プロテアソームによる生体制御 (2007)
  • Author(s): 村田 茂穂
  • Organizer: 第2回臨床ストレス応答学会特別講演
  • Place of Presentation: 福岡
  • Year and Date: 2007-12-01
• [Presentation] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development (2007)
  • Author(s): Jun Hamazaki, et. al.
  • Organizer: SPMDB2007 No.2-1
  • Place of Presentation: Beijing,China
  • Year and Date: 2007-11-06
• [Presentation] Regulation of positive selection of CD8 T cells by thymus-specific proteasomes (2007)
  • Author(s): Shigeo Murata, et. al.
  • Organizer: 第37回日本免疫学会総会Late Breaking symposium
  • Place of Presentation: 東京
  • Year and Date: 2007-11-02
• [Presentation] タンパク質の輪廻転生と生命科学 (2007)
  • Author(s): 田中 啓二
  • Organizer: 東京大学医学部生化学・栄養学講義
  • Place of Presentation: 東京
  • Year and Date: 2007-10-29
• [Presentation] プロテアソームの多様性による生命活動の制御とその分子基盤 (2007)
  • Author(s): 村田 茂穂
  • Organizer: 三菱生命研セミナー
  • Place of Presentation: 東京
  • Year and Date: 2007-10-25
• [Presentation] 選択的オートファジーと凝集体形成 (2007)
  • Author(s): 小松 雅明
  • Organizer: 公開シンポジウム「オートファジー:病態に迫る!」
  • Place of Presentation: 東京
  • Year and Date: 2007-09-22
• [Presentation] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development (2007)
  • Author(s): Jun Hamazaki, et. al.
  • Organizer: EMBO conference:Ubiquitin and Ubiquitin-like modifiers in cellular regulation、No.32
  • Place of Presentation: Riva del Garda,Italy
  • Year and Date: 2007-09-21
• [Presentation] Discovery of Thymoproteasomes-Implication for Thymic Selection (2007)
  • Author(s): Keiji Tanaka
  • Organizer: 2007 Korea-Japan Joint Symposium in Seoul
  • Place of Presentation: Seoul,Korea
  • Year and Date: 2007-09-05
• [Presentation] Regulation of positive selection of CD8 T cell by thymus-specific proteasomes (2007)
  • Author(s): Shigeo Murata
  • Organizer: The 7th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Hyogo
  • Year and Date: 2007-09-03
• [Presentation] オートファゴソームマーカーLC3システムにおけるE2様酵素Atg3欠損マウスの解析 (2007)
  • Author(s): 曽 友深, 他
  • Organizer: 第12回病態と治療におけるプロテアーゼとインヒビター学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-08-03
• [Presentation] プロテアソームの分子集合 (2007)
  • Author(s): 村田 茂穂
  • Organizer: 第5回日本ヒトプロテオーム機構大会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-30
• [Presentation] 蛋白質の輪廻転生と生命科学 (2007)
  • Author(s): 田中 啓二
  • Organizer: 京都大学医学部大学院講義
  • Place of Presentation: 京都
  • Year and Date: 2007-07-13
• [Presentation] 蛋白質の輪廻転生と生命科学 (2007)
  • Author(s): 田中 啓二
  • Organizer: 東京都神経科学総合研究所セミナー
  • Place of Presentation: 東京
  • Year and Date: 2007-07-12
• [Presentation] オートファジー(Self-eating)と神経変性疾患 (2007)
  • Author(s): 田中 啓二
  • Organizer: 第5回京都神経科学セミナー
  • Place of Presentation: 京都
  • Year and Date: 2007-07-03
• [Presentation] 蛋白質の輪廻転生と免疫 (2007)
  • Author(s): 田中 啓二
  • Organizer: 九州大学医学部生命基礎医学免疫学各論講義
  • Place of Presentation: 福岡
  • Year and Date: 2007-07-02
• [Presentation] プロテアソームの分子集合機構と分子多様性の解析 (2007)
  • Author(s): 田中 啓二
  • Organizer: 九州大学生体防御研究所セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2007-07-02
• [Presentation] プロテアソームの多様性による生命活動の制御とその分子基盤 (2007)
  • Author(s): 村田 茂穂
  • Organizer: 東京大学大学院薬学系研究科・生物系薬学セミナー
  • Place of Presentation: 東京
  • Year and Date: 2007-06-19
• [Presentation] 蛋白質の輪廻転生と生命科学 (2007)
  • Author(s): 田中 啓二
  • Organizer: 日本大学大学院医学研究科平成19年度講義
  • Place of Presentation: 東京
  • Year and Date: 2007-06-16
• [Presentation] 胸腺特異的プロテアソームによるCD8+T細胞分化制御 (2007)
  • Author(s): 村田 茂穂, 他
  • Organizer: 第17回KTCC
  • Place of Presentation: 京都
  • Year and Date: 2007-06-15
• [Presentation] Regulation of positive selection of CD8 T cells by thymus-specific proteasomes (2007)
  • Author(s): Shigeo Murata
  • Organizer: 理化学研究所免疫アレルギー科学総合研究センター講演
  • Place of Presentation: 横浜
  • Year and Date: 2007-06-13
• [Presentation] オートファジー欠損による凝集体形成機構 (2007)
  • Author(s): 小松 雅明
  • Organizer: 第59回日本細胞生物学会第40回日本発生生物学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-30
• [Presentation] Molecular basis for the diversity of mammalian proteasomes (2007)
  • Author(s): 村田 茂穂
  • Organizer: 第59回日本細胞生物学会、第40回日本発生生物学会合同年会
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-29
• [Presentation] タンパク質の品質管理と疾患そしてそのモデルマウス (2007)
  • Author(s): 田中 啓二
  • Organizer: 第54回日本実験動物学会総会シンポジウム疾患モデルマウス:系統樹立と表現型解析の新潮流
  • Place of Presentation: 江戸川区民ホール・タワーホール船堀 東京
  • Year and Date: 2007-05-23
• [Presentation] タンパク質の輪廻転生と生命科学 (2007)
  • Author(s): 田中 啓二
  • Organizer: メディカルゲノム専攻「システム細胞情報論」平成19年度講義
  • Place of Presentation: 医科研一号館・一階講堂 東京
  • Year and Date: 2007-05-11
• [Presentation] Impaired degradation of ubiquitinated proteins in Rpn10-deficient mice (2007)
  • Author(s): Riva del Garda, Italy
  • Organizer: THE UBIQUITIN FAMILY meeting、No.57
  • Place of Presentation: Cold Spring Harbor,New York
  • Year and Date: 2007-04-30
• [Presentation] Thymoproteasomes regulate development of CD8+ T cells in the thymus (2007)
  • Author(s): Shigeo Murata
  • Organizer: 3rd Zeuthener See Workshop 2007
  • Place of Presentation: Berlin
  • Year and Date: 2007-04-23
• [Presentation] Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes (2007)
  • Author(s): Shigeo Murata
  • Organizer: Koloquium in Universitatsmedizin Berlin
  • Place of Presentation: Berlin
  • Year and Date: 2007-04-19
• [Presentation] 蛋白質の死を決定する分解装置、第27会日本医学会総会2007・シンポジウム (2007)
  • Author(s): 田中 啓二
  • Organizer: 蛋白質の死と病気"ユビキチン・プロテアソームとオートファジー"
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-06
• [Presentation] 蛋白質の輪廻転生と生命科学 (2007)
  • Author(s): 田中 啓二
  • Organizer: 大阪大学微生物病研究所学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2007-02-07
• [Presentation] Protein Quality Control by Constitutive Autophag (2007)
  • Author(s): Keiji Tanaka., et. al.
  • Organizer: The Ubiquitin Family (CSHS Symposium):Quality Control
  • Place of Presentation: New York, USA
• [Presentation] Dciscovery of thymus-specific proteasomes"thymoproteasomes"that regulate the development of CDB+T cells (2007)
  • Author(s): Keiji Tanaka., et. al.
  • Organizer: COE INTERNATIONAL SYMPOSIUM 2007
  • Place of Presentation: Inamori/Yamauchi Hall,Kyoto University Kyoto,Japan
• [Presentation] Regulation of Thymic Selection by the Thymus-specific Proteasome "Thymoproteasome" (2007)
  • Author(s): Keiji Tanaka., et. al.
  • Organizer: EMBO CONFERENCE/Ubiquitin and Ubiqutin-like Modifiers in Cellular Regulation
  • Place of Presentation: Riva Del Garda,Italy
• [Presentation] Pathophysiology of Consitutive Autophagy (2007)
  • Author(s): Keiji Tanaka., et. al.
  • Organizer: The 20th Naito Conference/Innate Immunity in Medicine and Biology [III]
  • Place of Presentation: 湘南国際村センター神奈川
• [Presentation] Discovery of Thymus-specific Proteasomes "Thymoproteasome" that regalate the Development of CD8^+ T Cells (2007)
  • Author(s): Keiji Tanaka
  • Organizer: Intemational Symposium on Protein Modification and Degradafion in Beijing, SPMDB 2007
  • Place of Presentation: Beijing Friendship Hotel,Beijing,China
• [Presentation] ユニークな蛋白質分解システム・プロテアソームとオートファジー (2007)
  • Author(s): 田中 啓二
  • Organizer: 第11回Molecular Cardiovascular Conference
  • Place of Presentation: キロロ"ホテルピアノ"北海道余市郡赤井川村
• [Presentation] Structural basis for the selection of glycosylated substrates by SCFFbs1 ubiquitin ligase (2007)
  • Author(s): Yuko Maruoka., et. al.
  • Organizer: EMBO Conference 'Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation'
  • Place of Presentation: Riva del Garda,Italy
• [Presentation] Novel functions of a neural-specific F-box protein Fbs1 (2007)
  • Author(s): Yukiko Yoshida., et. al.
  • Organizer: EMBO Conference 'Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation'
  • Place of Presentation: Riva del Garda,Italy
• [Presentation] 新規F-boxタンパク質の標的分子の探索 (2007)
  • Author(s): 丸岡 裕子, 他
  • Organizer: BMB2007
  • Place of Presentation: 横浜
• [Presentation] 糖鎖認識F-boxタンパク質Fbs1の神経細胞における機能の解析 (2007)
  • Author(s): 吉田 雪子, 他
  • Organizer: BMB2007
  • Place of Presentation: 横浜
• [Presentation] ノックアウトマウスを用いたN型糖鎖を認識するSCF^<FBG2>ユビキチンリガーゼの機能解析 (2007)
  • Author(s): 吉田 雪子, 他
  • Organizer: BMB2007
  • Place of Presentation: 横浜
• [Presentation] PAC1/2/3 complex plays essential rule for the assembly of mammalian 20S proteasomes (2007)
  • Author(s): Yuko Hirana., et. al.
  • Organizer: 3rd Charite Zeuthener See workshop
  • Place of Presentation: Berlin,Germany
• [Presentation] Mechanism of assembly of mammalian 20S proteasomes (2007)
  • Author(s): Yuko Hirano
  • Organizer: SPN-DB2007(short talk)
  • Place of Presentation: Beijing,China
• [Presentation] 哺乳類における20S Proteasomeの分子集合機構について (2007)
  • Author(s): 平野 祐子, 他
  • Organizer: 病態と治療におけるプロテアーゼとインヒビター学会
  • Place of Presentation: 大阪
• [Presentation] 哺乳類20Sプロテアソームの段階的な形成機構について (2007)
  • Author(s): 平野 祐子, 他
  • Organizer: 第30回日本分子生物学会第80回生化学会大会
  • Place of Presentation: 横浜
• [Presentation] Identification and characterization of novel proteasome associated proteins in S.cerevisiae (2007)
  • Author(s): Hideki Yashiroda, et. al.
  • Organizer: The Ubiquitin Family
  • Place of Presentation: Cold Spring Hafbor laboratory,USA
• [Presentation] 20Sプロテアソーム会合支援複合体Dmp1/Dmp2の解析 (2007)
  • Author(s): 八代田 英樹, 他
  • Organizer: 第40回酵母遺伝学フォーラム
  • Place of Presentation: 大阪
• [Presentation] 出芽酵母20Sプロテアソーム形成に関わる纈シャペロン複合体 (2007)
  • Author(s): 八代田 英樹, 他
  • Organizer: BMB2007
  • Place of Presentation: 横浜
• [Presentation] Selective Autophagy Regulates Formation of Intracvtonlamic Inclusions (2007)
  • Author(s): Masaaki Komatsu
  • Organizer: Keystone Symposium on Autophagy in Health and Disease
  • Place of Presentation: Monterey,CA,USA
• [Presentation] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice (2007)
  • Author(s): Masaaki Komatsu, et. al.
  • Organizer: 国際シンポジウム「メンブレントラフィック」
  • Place of Presentation: Awajishima Hyogo,Japan
• [Presentation] The role of Atg8 conjugation system in mice (2007)
  • Author(s): Yu-shin Sou, et. al.
  • Organizer: 国際シンポジウム「メンブレントラフィック」
  • Place of Presentation: Awajishima Hyogo,Japan
• [Presentation] The role of Atg8 conjugation system in mice (2007)
  • Author(s): Yu-shin Sou, et. al.
  • Organizer: 第20回内藤カンファレンス「自然免疫の医学・生物学〔III〕」
  • Place of Presentation: Kanagawa,Japan
• [Presentation] Ufm1-conjugating system is essential for normal erythropoiesis (2007)
  • Author(s): Kanako Tatsumi., et. al.
  • Organizer: The 2007 meeting on THE UBIQUITIN FAMILY Poster No.118
  • Place of Presentation: Cold Spring Harbor,N.Y.USA
• [Presentation] Ufm1-conjugating system is essential for erythropoiesis (2007)
  • Author(s): Kanako Tatsumi., et. al.
  • Organizer: 2007 INTERNATIONAL SYMPOSIUM ON PROTEIN MODIFICATION AND DEGRADATION IN BEIJING(SPMDB2007)Poster No.3.5
  • Place of Presentation: Beijing,China
• [Presentation] 新しいユビキチン様修飾システムUfm1 systemの血液学的機能解析 (2007)
  • Author(s): 辰巳 加奈子, 他
  • Organizer: 第69回日本血液学会口演OS-40-1
  • Place of Presentation: 横浜
• [Book] 蛋白質の寿命 : 蛋白質の事典 (2009)
  • Author(s): 田中啓二
  • Publisher: 朝倉書店(印刷中)
• [Book] ユビキチンとプロテアソーム : 炎症・再生医学辞典 (2009)
  • Author(s): 田中啓二
  • Publisher: 朝倉書店(印刷中)
• [Book] ユビキチン・プロテアソーム・オートファジー : 免疫の事典 (2009)
  • Author(s): 田中啓二
  • Publisher: 朝倉書店(印刷中)
• [Book] 巨大で複雑な蛋白質分解装置の動態と作動機構「構造プロテオミクスの新時代 : 医薬の分子設計と構造生物学の融合」蛋白質核酸酵素 増刊号 (2009)
  • Author(s): 水島恒裕・田中啓二
  • Publisher: 共立出版(印刷中)
• [Book] 「分子細胞生物学辞典」:免疫プロテアソーム・ハイブリッドプロテアソーム (2008)
  • Author(s): 田中啓二
  • Publisher: 東京化学同人
• [Book] プロテアソーム:キーワード:蛋白質の一生「蛋白質核酸酵素」増刊号 (2008)
  • Author(s): 田中啓二
  • Publisher: 共立出版
• [Book] 蛋白質の寿命:蛋白質の事典 (2008)
  • Author(s): 田中啓二
  • Publisher: 朝倉書店
• [Book] ユビキチンと神経変性:臨床神経科学(Clinical Neuroscience) (2008)
  • Author(s): 田中啓二
  • Publisher: 中外医学社
• [Book] プロテアソームの新しいユビキチンレセプター. 細胞工学 (2008)
  • Author(s): 佐伯泰、田中啓二
  • Publisher: 学研メディカル秀潤社
• [Book] 「分子細胞生物学辞典」 : 免疫プロテアソーム・ハイブリッドプロテアソーム (2008)
  • Author(s): 田中啓二(分担)
  • Total Pages: 2
  • Publisher: 東京化学同人
• [Book] プロテアソーム : キーワード : 蛋白質の一生.蛋白質核酸酵素」増刊号 (2008)
  • Author(s): 田中啓二
  • Total Pages: 7
  • Publisher: 共立出版
• [Book] ユビキチン-プロテアソーム系「細胞の蛋白質品質管理機構と心血管疾患」血管医学 (2008)
  • Author(s): 田中啓二
  • Total Pages: 4
  • Publisher: メディカルレビュー社
• [Book] ユビキチンと神経変性 : 臨床神経科学(Clinical Neuroscience) (2008)
  • Author(s): 田中啓二
  • Total Pages: 2
  • Publisher: 中外医薬社
• [Book] プロテアソームの新しいユビキチンレセプター.細胞工学 (2008)
  • Author(s): 佐伯泰、田中啓二
  • Total Pages: 2
  • Publisher: 秀潤社
• [Book] Ubiquity and diversity of the proteasome system. In " Protein Degradation" (Eds. By Mayer, R. J., Ciechanover, A., and Rechsteiner, M.) (2006)
  • Author(s): Tanaka, K., Yashiroda, H., Murata, S.
  • Publisher: Wiley-VCH Verlag GmbH, Weinheim, Germany
• [Book] Ubiquity and diversity of the proteasome system. In "Protein Degradation"(Eds. By Mayer, R.J., Ciechanover, A., and Rechsteiner, M.) (2006)
  • Author(s): Tanaka, K.
  • Publisher: Wiley-VCH Verlag GmbH, Weinheim, Germany in press
• [Book] Large- and small-scale purification of mammalian 26S proteasomes. Methods in Enzymology (2005)
  • Author(s): Hirano, Y.
  • Publisher: Elseivier Inc..
• [Book] Preparation of proteasomes. in "Cell Biology : A Laboratory Handbook" (Ed. by J.E.Celis) 3rd edition. (2005)
  • Author(s): Tanaka, K.
  • Publisher: Academic Press, New York
• [Book] ユビキチン・プロテアソーム・オートファジー:免疫の事典
  • Author(s): 田中啓二
  • Publisher: 朝倉書店(印刷中)
• [Book] 巨大で複雑な蛋白質分解装置の動態と作動機構「構造プロテオミクスの新時代:医薬の分子設計と構造生物学の融合」蛋白質核酸酵素増刊号
  • Author(s): 水島恒裕・田中啓二
  • Publisher: 共立出版
• [Remarks] 研究代表者:田中啓
  • URL: http://www.rinshoken.or.jp/
• [Remarks] 研究分担者:村田茂穂
  • URL: http://www.f.u-tokyo.ac.jp/
• [Remarks] (1)研究代表者 : 田中啓二
  • URL: http://www.rinshoken.or.jp/
• [Remarks] (2)研究分担者 : 村田茂穂
  • URL: http://www.f.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.rinshoken.or.jp/