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がん研究の資材有効保存と利用に関する研究

Research Project

Project/Area Number 17012003
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

清木 元治  The University of Tokyo, 医科学研究所, 教授 (10154634)

Co-Investigator(Kenkyū-buntansha) 松居 靖久  東北大学, 加齢医学研究所, 教授 (40241575)
丹羽 太貫  京都大学, 放射線生物研究センター, 教授 (80093293)
佐竹 正延  東北大学, 加齢医学研究所, 教授 (50178688)
立松 正衛  愛知県がんセンター研究所, 副所長 (70117836)
福島 昭治  大阪市立大学, 大学院・医学研究科, 教授 (00137077)
中江 大  (財)佐々木研究所, 病理部, 部長 (90207712)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥44,200,000 (Direct Cost: ¥44,200,000)
Fiscal Year 2007: ¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2006: ¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2005: ¥24,000,000 (Direct Cost: ¥24,000,000)
Keywords腫瘍細胞株 / 可移植性 / 細胞バンク / 遺伝性疾患 / コホート研究 / DNA資料 / 病理解析 / 遺伝子改変マウス
Research Abstract

松居班員は、本年度は、ヒト細胞株983件、マウス細胞株268件、ラット細胞株73件、ハイブリドーマ79件、その他細胞株37件、施設別として集計すると、国内の大学及び公共機関1213件、民間機関178件、国外49件であり、合計1440件の細胞株を全国の研究者へ供給した。その他、平成19年度は1株の新規ヒト培養細胞株を収集した。
また、京都大学放射線生物研究センターで収集された遺伝子疾患患者由来の正常2倍体細胞株の保存が医薬基盤研究所に移動したことに伴った余剰予算で、ペプチド合成サービスを単年度限りの事業として行った。

Report

(3 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (15 results)

All 2007 2006 2005 Other

All Journal Article (15 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice2007

    • Author(s)
      Taniwaki, K., Seiki, M. (他10名)
    • Journal Title

      Cancer Research 67

      Pages: 4311-4319

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells2007

    • Author(s)
      Yana, I., Seiki, M. (他10名)
    • Journal Title

      J Cell Sci 120

      Pages: 1607-1614

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mistaken indentity of widely used esophageal adenocarcinoma cell line TE-72007

    • Author(s)
      Boonstra, JJ., Matsui, Y (他12)
    • Journal Title

      Cancer Research 67

      Pages: 7996-8001

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic control for induction of meiosis2007

    • Author(s)
      Matsui. Y 他1名
    • Journal Title

      Cell. Mol. Life Sci. 64

      Pages: 257-262

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells2006

    • Author(s)
      Egawa, N. 他5名
    • Journal Title

      J. Biol. Chem 281・49

      Pages: 37576-37585

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cell surface collagenolysis requires homodimenzation of the membrane-bound collagenase MT1-MMP2006

    • Author(s)
      Itoh, Y 他5名
    • Journal Title

      Mol Biol Cell 17・12

      Pages: 5390-5399

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Radiation induction of dynamic mutation and transecncrational effects2006

    • Author(s)
      Niwa, O.
    • Journal Title

      J. Radiat. Res. 47

      Pages: 25-30

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Indirect mechanisms of genomic instability and the biological significance of mutations at tandem repeat loci2006

    • Author(s)
      Niwa, O.
    • Journal Title

      Mutation Research 598

      Pages: 61-72

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of low density lipoprotein receptor-related protein 4(Lpr4) gene in the mouse germ cells.2006

    • Author(s)
      Yamaguchi, L. Y. 他5名
    • Journal Title

      Gene Expression Patterns 6

      Pages: 607-612

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Disruption of spermatogenic cell adhesion and male in fertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule.2006

    • Author(s)
      Yamada, D., NaKae, D, 他10名
    • Journal Title

      Mol.Biol.Cell 26(in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CC44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase2005

    • Author(s)
      Suenaga, N., Seiki, M., 他2名
    • Journal Title

      Oncogene 24・5

      Pages: 859-868

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Membrane-type 1 matrix metalloproteinase cytopiasmic tail binding protein-1(MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway2005

    • Author(s)
      Hirano, W., Seiki, M., 他2名
    • Journal Title

      Genes Cells 10・6

      Pages: 565-574

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates the clathrin-dependent endocytosis.2005

    • Author(s)
      Tanabe, K, Satake, M. 他3名
    • Journal Title

      Mol.Biol.Cell 16

      Pages: 1617-1628

    • NAID

      120002338809

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibitory effect of etodolac a selective cyclooxygenase-2 inhibitor, on stomach carcinogenesis in Helicobacter pylori-infected Mongolian gerbils

    • Author(s)
      Magari, H., Tatekatsu, M, 他12名
    • Journal Title

      Biochem Biophys Res Commun. 334・2

      Pages: 606-621

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Suppression of replication fork progression in low dose specific p53 dependent S-phase DNA damage checkpoint

    • Author(s)
      Shimura, T., Niwa, T.他7名
    • Journal Title

      Oncogene (in press)

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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