New Frontiers of Cancer Sciences

• Project/Area Number: 17012004
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: TANIGUCHI Tadatsugu The University of Tokyo, 大学院・医学系研究科, 教授 (50133616)
• Co-Investigator(Kenkyū-buntansha): 松田 道行 京都大学, 大学院・医学研究科, 教授 (10199812) ; 濡木 理 東京工業大学, 大学院・生命理工学研究科, 教授 (10272460) ; 西田 栄介 京都大学, 大学院・生命科学研究科, 教授 (60143369)
• Co-Investigator(Renkei-kenkyūsha): MATSUDA Michiyuki 京都大学, 大学院・医学研究科, 教授 (10199812) ; NUREKI Osamu 東京工業大学, 大学院・生命理工学研究科, 教授 (10272460) ; NISHIDA Eisuke 京都大学, 大学院・生命科学研究科, 教授 (60143369)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥8,400,000 (Direct Cost: ¥8,400,000); Fiscal Year 2009: ¥1,700,000 (Direct Cost: ¥1,700,000); Fiscal Year 2008: ¥1,700,000 (Direct Cost: ¥1,700,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000); Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000); Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: 情報科学 / がん免疫 / 構造生物学 / 発生と発がん / シグナル伝達

Research Abstract

This consortium project were established with the aim of developing and exploiting cutting-edge cancer research technologies and ideas. Overall, the entire project bore fruit in many areas including the discovery of novel molecules involved in the signaling and regulation of gene expression in cancer cells, development of new technologies for imaging of the signaling system, elucidation of the solid structure of several critical molecules for oncogenesis and new drug delivery system with which to treat cancers.

Research Products

• [Journal Article] The Caenorhabditis elegans Ste20-related kinase and Rac-type small GT Pase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response (2010)
  • Author(s): Fujiki K., et al.
  • Journal Title: Mol.Cell.Biol. 30 Pages: 995-1003
  • Peer Reviewed
• [Journal Article] The PHCCEx domain of Tiam1/2 is a novel protein-and membrane-binding module (2010)
  • Author(s): Terawaki S., et al.
  • Journal Title: EMBO J. 29 Pages: 236-250
  • Peer Reviewed
• [Journal Article] HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses (2009)
  • Author(s): Yanai H., et al.
  • Journal Title: Nature 462 Pages: 99-103
  • Peer Reviewed
• [Journal Article] The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes (2009)
  • Author(s): Nada S., et al.
  • Journal Title: EMBO J. 28 Pages: 477-489
  • Peer Reviewed
• [Journal Article] Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport (2009)
  • Author(s): Kosako H., et al.
  • Journal Title: Nat.Struct.Mol.Biol. 16 Pages: 1026-1035
  • Peer Reviewed
• [Journal Article] Dual role of Cdc42 in spindle orientation control of adherent cells (2009)
  • Author(s): Mitsushima M., et al.
  • Journal Title: Mol.Cell.Biol. 29 Pages: 2816-2827
  • Peer Reviewed
• [Journal Article] Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells (2009)
  • Author(s): Suzuki, S., Nakasato, M., Shibue, T., Koshima, I. and Taniguchi, T.
  • Journal Title: Cancer Science 100 Pages: 759-769
  • NAID: 10025144902
  • Peer Reviewed
• [Journal Article] Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning (2009)
  • Author(s): Hanafusa, H., Matsumoto, K . and Nishida, E.
  • Journal Title: Nat. Cell Biol. 11 Pages: 106-109
  • Peer Reviewed
• [Journal Article] Phosphorylation and activation of the Rac l and Cdc42 GEF Asef in A431 cells stimulated by EGF (2008)
  • Author(s): Itoh, R.E., Kiyokawa, E., Aoki, K., Nishioka, T., Akiyama, T.and Matsuda, M.
  • Journal Title: J. Cell Science 121 Pages: 2635-2642
  • Peer Reviewed
• [Journal Article] Conformational transition of Sec machinery inferred from bacterial SecYE structures (2008)
  • Author(s): Tsukazaki, T., Mori, H., Fukai, S., Ishitani, R., Mori, T., Dohmae, N., Perederina, A., Sugita, Y., Vassylyev, D.G., Ito, K.and Nureki, O.
  • Journal Title: Nature 455 Pages: 879-880
  • Peer Reviewed
• [Journal Article] Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit. (2008)
  • Author(s): Nakajima, H., Yonemura, S., Murata, M., Nakayama, N., Piwnica-Worms, H., and Nishida, E.
  • Journal Title: J. Cell Biol. 181 Pages: 89-103
  • Peer Reviewed
• [Journal Article] DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. (2007)
  • Author(s): Takaoka, A., Wang, Z., Choi, MK., Yanai, H., Negishi, H., Ban, T., Yan, L., Miyagishi, M., Kodama, T., Honda, K., Ohba, Y. and Taniguchi, T.
  • Journal Title: Nature. 448(26) Pages: 501-506
  • Peer Reviewed
• [Journal Article] An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of NGF-stimulated PC12 cells. (2007)
  • Author(s): Aoki, K., T. Nakamura, T. Inoue, T. Meyer, and M. Matsuda.
  • Journal Title: J. Cell Biol. 177 Pages: 817-827
  • Peer Reviewed
• [Journal Article] Crystal structure of the Sec4p-Sec2p complex in the nucleotide exchanging intermediate state. (2007)
  • Author(s): Y. Sato, S. Fukai, R. Ishitani, and O. Nureki.
  • Journal Title: Proc. Natl. Acad. Sci. 104 Pages: 8305-8310
  • Peer Reviewed
• [Journal Article] Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression. (2007)
  • Author(s): Yanai, H., Chen, H., Inuzuka, T., Kondo, S., Mak, W.T., Takaoka.A., Honda, K., Taniguchi, T.
  • Journal Title: PNAS 104 Pages: 3402-3407
• [Journal Article] GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. (2006)
  • Author(s): Kawase, K., Nakamura, T., Takaya, A., Aoki, K., Namikawa, K., Kiyama, H., Inagaki, S., Takemoto, H., Saltiel, A.R., Matsuda, M.
  • Journal Title: Dev.Cell 11 Pages: 411-421
• [Journal Article] Complete crystallographic analysis of the dynamics of CCA-addition. (2006)
  • Author(s): K.Tomita, R.Ishitani, S.Fukai, O.Nureki
  • Journal Title: Nature 443 Pages: 956-960
  • NAID: 130006997728
• [Journal Article] Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression. (2006)
  • Author(s): Yamamoto, T., Ebisuya, M., Ashida, F., Okamoto, K., Yonehara, S., Nishida, E.
  • Journal Title: Curr. Biol. 16 Pages: 1171-1182
• [Journal Article] Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms. (2006)
  • Author(s): Kondoh, K., Terasawa, K., Morimoto, H., Nishida, E.
  • Journal Title: Mol.Cell.Biol. 26 Pages: 1679-1690
• [Journal Article] Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. (2005)
  • Author(s): Takaoka A.,...Taniguchi T.
  • Journal Title: Nature 434 Pages: 243-249
• [Journal Article] Res binding opens c-Raf to expose the docking site for MEK. (2005)
  • Author(s): Terai, K., Matusuda, M.
  • Journal Title: EMBO Rep.6 Pages: 251-255
• [Journal Article] Structural basis for anticodon recognition by methionyl-tRNA synthetase (2005)
  • Author(s): K.Nakanishi, Y.Ogiso, S.Fukai, O.Nureki
  • Journal Title: Nat.Struct.Mol.Biol. 12 Pages: 931-932
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