• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

New Frontiers of Cancer Sciences

Research Project

Project/Area Number 17012004
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

TANIGUCHI Tadatsugu  The University of Tokyo, 大学院・医学系研究科, 教授 (50133616)

Co-Investigator(Kenkyū-buntansha) 松田 道行  京都大学, 大学院・医学研究科, 教授 (10199812)
濡木 理  東京工業大学, 大学院・生命理工学研究科, 教授 (10272460)
西田 栄介  京都大学, 大学院・生命科学研究科, 教授 (60143369)
Co-Investigator(Renkei-kenkyūsha) MATSUDA Michiyuki  京都大学, 大学院・医学研究科, 教授 (10199812)
NUREKI Osamu  東京工業大学, 大学院・生命理工学研究科, 教授 (10272460)
NISHIDA Eisuke  京都大学, 大学院・生命科学研究科, 教授 (60143369)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 2009: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2008: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords情報科学 / がん免疫 / 構造生物学 / 発生と発がん / シグナル伝達
Research Abstract

This consortium project were established with the aim of developing and exploiting cutting-edge cancer research technologies and ideas. Overall, the entire project bore fruit in many areas including the discovery of novel molecules involved in the signaling and regulation of gene expression in cancer cells, development of new technologies for imaging of the signaling system, elucidation of the solid structure of several critical molecules for oncogenesis and new drug delivery system with which to treat cancers.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (24 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (22 results) (of which Peer Reviewed: 14 results) Remarks (2 results)

  • [Journal Article] The Caenorhabditis elegans Ste20-related kinase and Rac-type small GT Pase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response2010

    • Author(s)
      Fujiki K., et al.
    • Journal Title

      Mol.Cell.Biol. 30

      Pages: 995-1003

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The PHCCEx domain of Tiam1/2 is a novel protein-and membrane-binding module2010

    • Author(s)
      Terawaki S., et al.
    • Journal Title

      EMBO J. 29

      Pages: 236-250

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses2009

    • Author(s)
      Yanai H., et al.
    • Journal Title

      Nature 462

      Pages: 99-103

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes2009

    • Author(s)
      Nada S., et al.
    • Journal Title

      EMBO J. 28

      Pages: 477-489

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport2009

    • Author(s)
      Kosako H., et al.
    • Journal Title

      Nat.Struct.Mol.Biol. 16

      Pages: 1026-1035

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual role of Cdc42 in spindle orientation control of adherent cells2009

    • Author(s)
      Mitsushima M., et al.
    • Journal Title

      Mol.Cell.Biol. 29

      Pages: 2816-2827

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells2009

    • Author(s)
      Suzuki, S., Nakasato, M., Shibue, T., Koshima, I. and Taniguchi, T.
    • Journal Title

      Cancer Science 100

      Pages: 759-769

    • NAID

      10025144902

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning2009

    • Author(s)
      Hanafusa, H., Matsumoto, K . and Nishida, E.
    • Journal Title

      Nat. Cell Biol. 11

      Pages: 106-109

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation and activation of the Rac l and Cdc42 GEF Asef in A431 cells stimulated by EGF2008

    • Author(s)
      Itoh, R.E., Kiyokawa, E., Aoki, K., Nishioka, T., Akiyama, T.and Matsuda, M.
    • Journal Title

      J. Cell Science 121

      Pages: 2635-2642

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformational transition of Sec machinery inferred from bacterial SecYE structures2008

    • Author(s)
      Tsukazaki, T., Mori, H., Fukai, S., Ishitani, R., Mori, T., Dohmae, N., Perederina, A., Sugita, Y., Vassylyev, D.G., Ito, K.and Nureki, O.
    • Journal Title

      Nature 455

      Pages: 879-880

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit.2008

    • Author(s)
      Nakajima, H., Yonemura, S., Murata, M., Nakayama, N., Piwnica-Worms, H., and Nishida, E.
    • Journal Title

      J. Cell Biol. 181

      Pages: 89-103

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.2007

    • Author(s)
      Takaoka, A., Wang, Z., Choi, MK., Yanai, H., Negishi, H., Ban, T., Yan, L., Miyagishi, M., Kodama, T., Honda, K., Ohba, Y. and Taniguchi, T.
    • Journal Title

      Nature. 448(26)

      Pages: 501-506

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of NGF-stimulated PC12 cells.2007

    • Author(s)
      Aoki, K., T. Nakamura, T. Inoue, T. Meyer, and M. Matsuda.
    • Journal Title

      J. Cell Biol. 177

      Pages: 817-827

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the Sec4p-Sec2p complex in the nucleotide exchanging intermediate state.2007

    • Author(s)
      Y. Sato, S. Fukai, R. Ishitani, and O. Nureki.
    • Journal Title

      Proc. Natl. Acad. Sci. 104

      Pages: 8305-8310

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.2007

    • Author(s)
      Yanai, H., Chen, H., Inuzuka, T., Kondo, S., Mak, W.T., Takaoka.A., Honda, K., Taniguchi, T.
    • Journal Title

      PNAS 104

      Pages: 3402-3407

    • Related Report
      2006 Annual Research Report
  • [Journal Article] GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion.2006

    • Author(s)
      Kawase, K., Nakamura, T., Takaya, A., Aoki, K., Namikawa, K., Kiyama, H., Inagaki, S., Takemoto, H., Saltiel, A.R., Matsuda, M.
    • Journal Title

      Dev.Cell 11

      Pages: 411-421

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Complete crystallographic analysis of the dynamics of CCA-addition.2006

    • Author(s)
      K.Tomita, R.Ishitani, S.Fukai, O.Nureki
    • Journal Title

      Nature 443

      Pages: 956-960

    • NAID

      130006997728

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression.2006

    • Author(s)
      Yamamoto, T., Ebisuya, M., Ashida, F., Okamoto, K., Yonehara, S., Nishida, E.
    • Journal Title

      Curr. Biol. 16

      Pages: 1171-1182

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms.2006

    • Author(s)
      Kondoh, K., Terasawa, K., Morimoto, H., Nishida, E.
    • Journal Title

      Mol.Cell.Biol. 26

      Pages: 1679-1690

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.2005

    • Author(s)
      Takaoka A.,...Taniguchi T.
    • Journal Title

      Nature 434

      Pages: 243-249

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Res binding opens c-Raf to expose the docking site for MEK.2005

    • Author(s)
      Terai, K., Matusuda, M.
    • Journal Title

      EMBO Rep.6

      Pages: 251-255

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural basis for anticodon recognition by methionyl-tRNA synthetase2005

    • Author(s)
      K.Nakanishi, Y.Ogiso, S.Fukai, O.Nureki
    • Journal Title

      Nat.Struct.Mol.Biol. 12

      Pages: 931-932

    • Related Report
      2005 Annual Research Report
  • [Remarks]

    • URL

      http://gantoku3.umin.jp/about/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://gantoku3.umin.jp/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi