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Structural basis for carcinogenesis and cancer metastasis by oncogene products

Research Project

Project/Area Number 17012009
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo (2007-2009)
Tokyo Institute of Technology (2005-2006)

Principal Investigator

NUREKI Osamu  The University of Tokyo, 医科学研究所, 教授 (10272460)

Co-Investigator(Kenkyū-buntansha) ISHITANI Ryuichiro  東京大学, 大学院・理学系研究科, 准教授 (90361568)
石谷 隆一郎  東京工業大学, 大学院生命理工学研究科, 助手 (30401186)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥123,800,000 (Direct Cost: ¥123,800,000)
Fiscal Year 2009: ¥25,000,000 (Direct Cost: ¥25,000,000)
Fiscal Year 2008: ¥25,000,000 (Direct Cost: ¥25,000,000)
Fiscal Year 2007: ¥25,000,000 (Direct Cost: ¥25,000,000)
Fiscal Year 2006: ¥25,000,000 (Direct Cost: ¥25,000,000)
Fiscal Year 2005: ¥23,800,000 (Direct Cost: ¥23,800,000)
Keywordsがん化 / がん細胞の転移 / 細胞骨格再構築 / 開口放出 / 転写因子 / 自然免疫 / X線結晶構造解析 / 発がん / がんの転移 / 創薬 / TGF-βシグナル / 細胞内ホメオスタシス / シグナル伝達 / レセプター / がん遺伝子 / 薬剤設計 / がん細胞の浸潤 / 細胞骨格再形成 / 細胞膜の開口放出 / 低分子量Gタンパク質 / Wnt / β-catenineシグナル
Research Abstract

To elucidate the mechanism of carcinogenesis, cancer metastasis and anti-tumor immune reaction, atomic structures of the player, the oncoproteins and anti-oncoproteins will be determined by X-ray crystallography. Based on the structures, new anti-cancer drug will be developed to achieve an efficient cancer treatment. For carcinogenesis, we focus on TGF-β signal under which many transcription regulatory molecules interplay for cellular development signal transduction. For cancer metastasis and invasion, we focus on proteins responsible for cytoskeleton reorganization and plasma membrane supply coupled with exocytosis. For innate immune reaction, we focus on Toll-like receptor (TLR) and its endogenous ligands, and on IRF transcriptional regulators acting mainly under the control of TLR to activate the transcription of proinflammatory cytokines and γ-interferon.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (68 results)

All 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article (45 results) (of which Peer Reviewed: 5 results) Presentation (16 results) Book (6 results) Remarks (1 results)

  • [Journal Article] Structure and function of a membrane component SecDF that enhances protein export2011

    • Author(s)
      T.Tsukazaki, H.Mori, Y.Echizen, R.Ishitani, S.Fukai, T.Tanaka, A.rederina, D.G.Vassylyev, T.Kohno, A.D.Maturana, K.Ito, O.Nureki
    • Journal Title

      Nature in press

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog2011

    • Author(s)
      L.Bonnefond, T.Arai, Y.Sakaguchi, T.Suzuki, R.Ishitani, O.Nureki
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 108

      Pages: 3912-3917

    • Related Report
      2009 Final Research Report
  • [Journal Article] Crystal structure of autotaxin and insight into GPCR activation by lipid mediators2011

    • Author(s)
      H.Nishimasu, S.Okudaira, K.Hama, E.Mihara, N.Dohmae, A.Inoue, R.Ishitani, J.Takagi, J.Aoki, O.Nureki
    • Journal Title

      Nat.Struct.Mol.Biol. 18

      Pages: 205-212

    • Related Report
      2009 Final Research Report
  • [Journal Article] Crystal structure of autotaxin and insight into GPCR activation by lipid mediators2011

    • Author(s)
      H.Nishimasu
    • Journal Title

      Nat.Struct.Mol.Biol.

      Volume: 18 Pages: 205-212

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Omnipotent role of archaeal elongation factor 1 alpha (EF1α in translational elongation and termination, and quality control of protein synthesis2010

    • Author(s)
      K.Saito, K.Kobayashi, M.Wada, I.Kikuno, A.Takusagawa, M.Mochizuki, T.Uchiumi, R.Ishitani, O.Nureki, K.Ito
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 107

      Pages: 19242-19247

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structural Basis for mRNA Surveillance by Archaeal Pelota and GTP-bound EF1? Complex2010

    • Author(s)
      K.Kobayashi, I.Kikuno, K.Kuroha, K.Saito, K.Ito, R.Ishitani, T.Inada, O.Nureki
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 107

      Pages: 17575-17579

    • Related Report
      2009 Final Research Report
  • [Journal Article] Mg^<2+>-dependent gating of bacterial MgtE channel underlies Mg^<2+> homeostasis2009

    • Author(s)
      M.Hattori, N.Iwase, N.Furuya, Y.Tanaka, T.Tsukazaki, R.Ishitani, M.E.Maguire, K.Ito, A.Maturana, O.Nureki
    • Journal Title

      EMBO J 28

      Pages: 3602-3612

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structural basis for translational fidelity ensured by tRNA lysidine synthetase2009

    • Author(s)
      K.Nakanishi, L.Bonnefond, S.Kimura, T.Suzuki, R.Ishitani, O.Nureki.
    • Journal Title

      Nature 461

      Pages: 1144-1148

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structural basis of novel interactions between the small-GTPase and GDI-like domains in prokaryotic FeoB iron transporter.2009

    • Author(s)
      M.Hattori, Y.Jin, H.Nishimasu, Y.Tanaka, M.Mochizuki, T.Uchiumi, R.Ishitani, K.Ito, O.Nureki.
    • Journal Title

      Structure 17

      Pages: 1345-1355

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structure of a tRNA-dependent kinase essential for selenocysteine decoding.2009

    • Author(s)
      Y.Araiso, R.L.Sherrer, R.Ishitani, J.M.L.Ho, D.Soll, O.Nureki.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 106

      Pages: 16215-16220

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2.2009

    • Author(s)
      M.Umitsu, H.Nishimasu, A.Noma, T.Suzuki, R.Ishitani, O.Nureki
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 106

      Pages: 15616-15621

    • Related Report
      2009 Final Research Report
  • [Journal Article] Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases.2009

    • Author(s)
      R.Shirakawa, S.Fukai, M.Kawato, T.Higashi, H.Kondo, T.Ikeda, E.Nakayama, K.Okawa, O.Nureki, T.Kimura, T.Kita, H.Horiuchi.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 21580-21588

    • Related Report
      2009 Final Research Report
  • [Journal Article] Conserved Cysteine Residues of GidA Are Essential for Biogenesis of 5-Carboxymethylaminomethyluridine at tRNA Anticodon2009

    • Author(s)
      T.Osawa, K.Ito, H.Inanaga, O.Nureki, K.Tomita, T.Numata.
    • Journal Title

      Structure. 17

      Pages: 713-724

    • Related Report
      2009 Final Research Report
  • [Journal Article] Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase2009

    • Author(s)
      H.Nishimasu, R.Ishitani, K.Yamashita, C.Iwashita, A.Hirata, H.Hori, O.Nureki
    • Journal Title

      Proc.Natl.Acad.USA. 106

      Pages: 8180-8185

    • Related Report
      2009 Final Research Report
  • [Journal Article] Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator2009

    • Author(s)
      A.Seto, H.Ikushima, T.Suzuki, Y.Sato, S.Fukai, K.Yuki, K.Miyazawa, K.Miyazono, R.Ishitani, O.Nureki
    • Journal Title

      Acta Crystallogr.Sect.F. 65

      Pages: 21-24

    • Related Report
      2009 Final Research Report
  • [Journal Article] Pyrrolysyl-tRNA synthetase-tRNA(Pyl) structure reveals the molecular basis of orthogonality2009

    • Author(s)
      K.Nozawa, P.O'Donoghue, S.Gundllapalli, Y.Araiso, R.Ishitani, T.Umehara, D.Soll, O.Nureki
    • Journal Title

      Nature 457

      Pages: 1163-1167

    • Related Report
      2009 Final Research Report
  • [Journal Article] Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases.2009

    • Author(s)
      R.Shirakawa, et al.
    • Journal Title

      J.Biol.Chem.

      Volume: 284 Pages: 21580-21588

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformational transition of Sec machinery inferred from bacterial SecYE structures2008

    • Author(s)
      T.Tsukazaki, H.Mori, S.Fukai, R.Ishitani, T.Mori, N.Dohmae, A.Perederina, Y.Sugita, D.G.Vassylyev, K.Ito, O.Nureki
    • Journal Title

      Nature 455

      Pages: 988-991

    • Related Report
      2009 Final Research Report
  • [Journal Article] Mg^<2+>-sensing mechanism of Mg^<2+> transporter MgtE probed by molecular dynamics study2008

    • Author(s)
      R.Ishitani, Y.Sugita, N.Dohmae, N.Furuya, M.Hattori, O.Nureki
    • Journal Title

      Proc.Natl.Acad.USA. 105

      Pages: 15393-15398

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains2008

    • Author(s)
      Y.Sato, A.Oshikawa, A.Yamagata, H.Mimura, M.Yamashita, K.Ookata, O.Nureki, K.Iwai, M.Komada, S.Fukai
    • Journal Title

      Nature 455

      Pages: 358-362

    • Related Report
      2009 Final Research Report
  • [Journal Article] Biochemical Characterization of the Rho GTPase-regulated Actin Assembly by Diaphanous-related Formins, mDia1 and Daam1, in Platelets2008

    • Author(s)
      T.Higashi, T.Ikeda, R.Shirakawa, H.Kondo, M.Kawato, M.Horiguchi, T.Okuda, K.Okawa, S.Fukai, O.Nureki, T.Kita, H.Horiuchi.
    • Journal Title

      J.Biol.Chem. 283

      Pages: 8746-8755

    • Related Report
      2009 Final Research Report
  • [Journal Article] Regulation of platelet dense granule secretion by the Ral GTPase-Exocyst pathway2008

    • Author(s)
      M.kawato, R.Shirakawa, H.Kondo, T.Higashi, T.Ikeda, K.Okawa, S.Fukai, O.Nureki, T.Kita, H.Horiuchi
    • Journal Title

      J.Biol.Chem. 283

      Pages: 166-174

    • Related Report
      2009 Final Research Report
  • [Journal Article] Biochemical Characterization of the Rho GTPase-regulated Actin Assembly by Diaphanous-related Formins, mDial and Daaml, in Platelets2008

    • Author(s)
      T. Higashi, T. Ikeda, R. Shirakawa, H. Kondo, M. Kawato, M. Horiguchi, T. Okuda, K. Okawa, S. Fukai, O. Nureki, T. Kita, H. Horiuchi
    • Journal Title

      J. Biol. Chem. 283

      Pages: 8746-8755

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of platelet dense granule secretion by the Ral GTPase-Exocyst pathway2008

    • Author(s)
      M. kawato, R. Shirakawa, H. Kondo, T. Higashi, T. Ikeda, K. Okawa, S. Fukai, O. Nureki, T. Kita. H. Horiuchi
    • Journal Title

      J. Biol. Chem. 283

      Pages: 166-174

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary X-ray diffraction analysis of GCIP/HRM transcriptional regulator2008

    • Author(s)
      A. Seto, H. Ikushima, T. Suzuki , Y. Sato, S. Fukai, K. Yuki, K. Miyazawa, K. Miyazono, R. Ishitani and O. Nureki
    • Journal Title

      Acta Crystallogr. Sect. F. 65

      Pages: 21-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of human DAAM1 formin homology 2 domain2007

    • Author(s)
      M.Yamashita, T.Higashi, S.Suetsugu, Y.Sato, T.Ikeda, R.Shirakawa, T.Kita, T.Takenawa, H.Horiuchi, S.Fukai, O.Nureki
    • Journal Title

      Genes Cells 12

      Pages: 1255-1265

    • Related Report
      2009 Final Research Report
  • [Journal Article] Crystal structure of the MgtE Mg2+ transporter2007

    • Author(s)
      M Hattori, Y.Tanaka, S.Fukai, R.Ishitani, O.Nureki
    • Journal Title

      Nature 448

      Pages: 1072-1075

    • Related Report
      2009 Final Research Report
  • [Journal Article] Crystal structure of the Sec4p・Sec2p complex in the nucleotide exchanging intermediatetate2007

    • Author(s)
      Y.Sato, S.Fukai, R.Ishitani, O.Nureki
    • Journal Title

      Proc.Natl.Acad.Sci.USA 104

      Pages: 8305-8310

    • Related Report
      2009 Final Research Report
  • [Journal Article] Asymmetric coiled-coil structure with guanine nucleotide exchange activity2007

    • Author(s)
      Sato, R.Shirakawa, H.Horiuchi, N.Dohmae, S.Fukai, O.Nureki
    • Journal Title

      Structure 15

      Pages: 245-252

    • Related Report
      2009 Final Research Report
  • [Journal Article] Asymmetric coiled-coil structure with guanine nucleotide exchange activity2007

    • Author(s)
      Y.Sato, R.Shirakawa, H.Horiuchi, N.Dohmae, S.Fukai, O.Nureki
    • Journal Title

      Structure 15

      Pages: 245-252

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Crystal structure of the Sec4poSec2p complex in the nucleotide exchanging intermediate state2007

    • Author(s)
      Y.Sato, S.Fukai, R.Ishitani, O.Nureki
    • Journal Title

      Proc. Natl. Acad. Sci. USA 21(in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Complete crystallographic analysis of the dynamics of CCA-addition2006

    • Author(s)
      K.Tomita, R.Ishitani, S.Fukai, O.Nureki
    • Journal Title

      Nature 443

      Pages: 956-960

    • NAID

      130006997728

    • Related Report
      2009 Final Research Report 2006 Annual Research Report
  • [Journal Article] Structural basis of RNA-dependent recruitment of glutamine to the genetic code2006

    • Author(s)
      H.Oshikane, K.Sheppard, S.Fukai, Y.Nakamura, R.Ishitani, T.Numata, L.R.Sherrer, L.Feng, E.Schmitt, M.Panvert, S.Blanquet, Y.Mechulam, D.Soll, O.Nureki
    • Journal Title

      Science 312

      Pages: 1950-1954

    • Related Report
      2009 Final Research Report
  • [Journal Article] Snapshots of tRNA sulfuration via an adenylated intermediate2006

    • Author(s)
      T.Numata, Y.Ikeuchi, S.Fukai, T.Suzuki, O.Nureki
    • Journal Title

      Nature 442

      Pages: 419-424

    • Related Report
      2009 Final Research Report 2006 Annual Research Report
  • [Journal Article] Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa2006

    • Author(s)
      T.Sengoku, O.Nureki, A.Nakamura, S.Kobayashi, S.Yokoyama
    • Journal Title

      Cell 125

      Pages: 287-300

    • Related Report
      2009 Final Research Report 2006 Annual Research Report
  • [Journal Article] Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex2006

    • Author(s)
      T.Numata, S.Fukai, Y.Ikeuchi., T.Suzuki., O.Nureki
    • Journal Title

      Structure 14

      Pages: 357-366

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structural basis of RNA-dependent recruitment of glutamine to the genetic code2006

    • Author(s)
      (12名)D.Soll, 0.Nureki
    • Journal Title

      Science 312

      Pages: 1950-1954

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex2006

    • Author(s)
      T.Numata, S.Fukai, Y.Ikeuchi, T.Suzuki, O.Nureki
    • Journal Title

      Structure 14

      Pages: 357-366

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural basis for anticodon recognition by methionyl-tRNA synthetase2005

    • Author(s)
      K.Nakanishi, Y.Ogiso, S.Fukai, O.Nureki
    • Journal Title

      Nature Struct.Mol.Biol. 12

      Pages: 931-932

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structural basis for lysidine formation by ATP pyrophosphatase accompanied with alysine-specific loop and a tRNA-recognition domain2005

    • Author(s)
      K.Nakanishi, S.Fukai, Y.Ikeuchi, A.Soma, Y.Sekine, T.Suzuki, O.Nureki
    • Journal Title

      Proc.Natl.Acad.Sci.USA 21

      Pages: 7487-7492

    • Related Report
      2009 Final Research Report
  • [Journal Article] Roles of conserved amino acid sequence motifs in the SpoU(TrmH) RNA methyltransferase family2005

    • Author(s)
      K.Watanabe, O.Nureki, S.Fukai, R.Ishii, H.Okamoto, S.Yokoyama, Y.Endo, H.Hori
    • Journal Title

      J Biol Chem 280

      Pages: 10368-10377

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural basis for lysidine formation by ATP pyrophosphatase accompanied with a lysine-specific loop and a tRNA-recognition domain2005

    • Author(s)
      K.Nakanishi, S.Fukai, Y.Ikeuchi, A.Soma, Y.Sekine, T.Suzuki, O.Nureki
    • Journal Title

      Proc.Natl.Acad.Sci.USA 21

      Pages: 7487-7492

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Recent progress of structural biology of tRNA processing and modification2005

    • Author(s)
      K.Nakanishi, O.Nureki
    • Journal Title

      Mol.Cells 19

      Pages: 157-166

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural basis for anticodon recognition by methionyl-tRNA synthetase2005

    • Author(s)
      K.Nakanishi, Y.Ogiso, T.Nakama, S.Fukai, O.Nureki
    • Journal Title

      Nat.Struct.Mol.Biol 12

      Pages: 931-932

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa

    • Author(s)
      T.Sengoku, O.Nureki, A.Nakamura, S.Kobayashi, S.Yokoyama
    • Journal Title

      Cell (in press)

    • Related Report
      2005 Annual Research Report
  • [Presentation] New structure-based drug design of cell motility activating factor, ATX2011

    • Author(s)
      O.Nureki
    • Organizer
      BioPharma China Congress 2011
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2011-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multiple conformational states of Sec machinery components implicated from bacterial SecYE crystal structure2009

    • Author(s)
      O.Nureki
    • Organizer
      VIII European Symposium of The Protein Society
    • Place of Presentation
      Zurich, Switzerland
    • Related Report
      2009 Final Research Report
  • [Presentation] 11^<th> International Congress on Amino Acids, Peptides and Proteins2009

    • Author(s)
      O.Nureki
    • Organizer
      Genetic code expansion by non-canonical tRNA synthetases
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2009 Final Research Report
  • [Presentation] 発がんとがん転移の構造生物学2008

    • Author(s)
      濡木理(以下10名)
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report 2007 Annual Research Report
  • [Presentation] Crystal structure of the MgtE Mg^<2+> transporter2008

    • Author(s)
      O.Nureki
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      CA, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Gating control mechanism of magnesium transporter MgtE2008

    • Author(s)
      O.Nureki
    • Organizer
      The Joint 2^<nd> Pacific Rim International Conference on Protein Science
    • Place of Presentation
      Cairns, Australia
    • Related Report
      2009 Final Research Report
  • [Presentation] Stop codon recoding mechanism revealed by the suppressor tRNAPyl and PylS complex structure2008

    • Author(s)
      O.Nureki
    • Organizer
      ULP-JSPS forum
    • Place of Presentation
      Strasbourg, France
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetc code extension and establishment by aminoacyl-tRNA synthetase and tRNA modification enzymes2008

    • Author(s)
      O.Nureki
    • Organizer
      aaRS2008
    • Place of Presentation
      Veyrier du Lac, France
    • Related Report
      2009 Final Research Report
  • [Presentation] Structural basis for highly specific chemical reaction in the genetic code translation2007

    • Author(s)
      O.Nureki
    • Organizer
      A Three-day Symposium on Advances in Structural Biology and Structure Prediction
    • Place of Presentation
      Hyderabad, India
    • Related Report
      2009 Final Research Report
  • [Presentation] Structural basis for highly specific chemical reaction in the genetic code translation2007

    • Author(s)
      O.Nureki
    • Organizer
      International Symposium on Chemical Biology
    • Place of Presentation
      Kolkata, India
    • Related Report
      2009 Final Research Report
  • [Presentation] Structural Insights into Translational Quality Control2007

    • Author(s)
      O.Nureki
    • Organizer
      American Society for Microbiology General 107^<th> Meeting
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2009 Final Research Report
  • [Presentation] Structural insights into the modification in the tRNA anticodon region2007

    • Author(s)
      O.Nureki
    • Organizer
      FEBS-CNRS Workshop
    • Place of Presentation
      Aussois, France
    • Related Report
      2009 Final Research Report
  • [Presentation] Structural insights into the gating control in bacterial transporters2007

    • Author(s)
      O.Nureki
    • Organizer
      AsCA'07 (Plenary lecture)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2009 Final Research Report
  • [Presentation] Deep knot folding of methyltransferase structures2006

    • Author(s)
      O.Nureki
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Vermont, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Structural Basis of RNA-Dependent Recruitment of Amino Acid to the Genetic Code2006

    • Author(s)
      O.Nureki
    • Organizer
      International Conference on aaRSs
    • Place of Presentation
      San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Structural biology on translation of genetic code2005

    • Author(s)
      O.Nureki
    • Organizer
      The 10th Symposium on Recent Advances in Biophysics (Plenary Lecture)
    • Place of Presentation
      Taipei, Taiwan(2005)
    • Related Report
      2009 Final Research Report
  • [Book] 日本結晶学会誌2011

    • Author(s)
      西増弘志, 喬木淳一, 青木淳賢, 濡木理
    • Publisher
      脂質メディエーター産生酵素ATXの結晶構造(刊行確定)
    • Related Report
      2009 Annual Research Report
  • [Book] RNA修飾マシーナリーの時間分解能での反応機構(蛋白質核酸酵素) 51巻2006

    • Author(s)
      濡木理
    • Publisher
      共立出版社
    • Related Report
      2009 Final Research Report
  • [Book] RNA修飾マシーナリーの時間分解能での反応機構2006

    • Author(s)
      濡木 理
    • Publisher
      蛋白質核酸酵素
    • Related Report
      2006 Annual Research Report
  • [Book] 細胞の生と死を統括するアミノアシルtRNA合成酵素複合体(蛋白質核酸酵素) 50巻2005

    • Author(s)
      濡木理
    • Publisher
      共立出版社
    • Related Report
      2009 Final Research Report
  • [Book] RNA成熟マシーン(実験医学) 22巻2005

    • Author(s)
      濡木理
    • Publisher
      羊土社
    • Related Report
      2009 Final Research Report
  • [Book] ヒト由来トリプトファニルtRNA合成酵素による血管新生抑制機構の構造的基盤2005

    • Author(s)
      濡木 理
    • Total Pages
      5
    • Publisher
      日本生物物理学会
    • Related Report
      2005 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.nurekilab.net/

    • Related Report
      2009 Final Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

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