Regulation of signal transduction by cancer-related genes

• Project/Area Number: 17012010
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nagoya University
• Principal Investigator: KUNIHIRO Matsumoto Nagoya University, 大学院・理学研究科, 教授 (70116375)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥84,700,000 (Direct Cost: ¥84,700,000); Fiscal Year 2009: ¥16,900,000 (Direct Cost: ¥16,900,000); Fiscal Year 2008: ¥16,900,000 (Direct Cost: ¥16,900,000); Fiscal Year 2007: ¥16,900,000 (Direct Cost: ¥16,900,000); Fiscal Year 2006: ¥16,900,000 (Direct Cost: ¥16,900,000); Fiscal Year 2005: ¥17,100,000 (Direct Cost: ¥17,100,000)
• Keywords: MAPキナーゼ / シグナル伝達 / 癌 / 増殖 / リン酸化 / TAK1 / シグナル伝達経路 / ノックアウトマウス / プロテインキナーゼ / 細胞死 / 活性酵素 / EGFR / 細胞周期 / 増殖因子 / モーター蛋白質 / 細胞内トラフィック / 活性酸素 / Wnt

Research Abstract

We have previously identified TAK1 kinase, a member of mitogen-activated kinase kinase kinase, as an indispensable signaling molecule in proinflammatory signaling pathways. In this project, we aimed to define the role of TAK1 signaling in an in vivo setting in both normal and tumor epithelial tissues. We identified that TAK1 regulates reactive oxygen species and epithelial cell survival. TAK1 deficiency causes massive cell death in tumor tissues that generate a higher level of ROS compared to normal tissues. Thus, TAK1 kinase could be a new and effective target for tumor killing.

Research Products

• [Journal Article] Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex (2010)
  • Author(s): Ishitani, T., Hirao, T., Suzuki, M., Isoda, M., Ishitani, S., Harigaya, K., Kitagawa, M., Matsumoto, K,,, Itoh, M.
  • Journal Title: Nature Cell Biol 12 Pages: 278-285
  • NAID: 120005293254
  • Peer Reviewed
• [Journal Article] Phosphorylation of the Conserved Transcription Factor ATF-7 by PMK-1 p38 MAPK Regulates Innate Immunity in Caenorhabditis elegans (2010)
  • Author(s): Shivers, R.P., Pagano, D.J., Kooistra1, T., Richardson, C.E., Reddy, K.C., Whitney, J.K., Matsumoto, K., Hisamoto, N.,, Kim, D.H.
  • Journal Title: PLoS Genet 6
  • Peer Reviewed
• [Journal Article] The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the JNK signaling pathway mediating the stress response (2010)
  • Author(s): Fujiki, K., Mizuno, T., Hisamoto, N.,, Matsumoto, K.
  • Journal Title: Mol. Cell. Biol. 30 Pages: 995-1003
  • Peer Reviewed
• [Journal Article] J. A TAK1 kinase adaptor, TAB2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in TNF signaling pathway (2010)
  • Author(s): Broglie, P., Matsumoto, K., Akira, S., Brautigan, D.L.,, Ninomiya-Tsuji
  • Journal Title: J. Biol. Chem. 285 Pages: 2333-2339
  • Peer Reviewed
• [Journal Article] Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells (2010)
  • Author(s): Takamatsu, R., Teruya, H., Takeshima, E., Ishikawa, C., Matsumoto, K., Mukaida, N., Li, J-D., Heuner, K., Higa, F., Fujita, J.,, Mori, N.
  • Journal Title: BMC Micro 8 Pages: 7-16
  • NAID: 120001968714
  • Peer Reviewed
• [Journal Article] The Caenorhabditis elegans Ste20-related kinase and Rae-type small GTPase regulate the JNK (2010)
  • Author(s): Fujiki, K., Mizuno, T., Hisamoto, N., Matsumoto, K.
  • Journal Title: Mol.Cell.Biol. 30 Pages: 995-1003
  • Peer Reviewed
• [Journal Article] A TAK1 kinase adaptor, TAB2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in TNF signaling pathway (2010)
  • Author(s): Broglie, P., Matsumoto, K., Akira, S., Brautigan, D.L., Ninomiya-Tsuji, J.
  • Journal Title: J.Biol.Chem. 285 Pages: 2333-2339
  • Peer Reviewed
• [Journal Article] Regulation of the ERK activity duration by Sprouty contributes to dorsoventral patterning (2009)
  • Author(s): Hanafusa, H., Matsumoto, K.,, Nishida, E.
  • Journal Title: Nature Cell Biol. 11 Pages: 106-109
  • Peer Reviewed
• [Journal Article] LRRK2 modulates vulnerability to mitochondrial dysfunction in C (2009)
  • Author(s): Lanceta, J., Chan, D., Ghosh, J., Hsu, C., Segal, L., Raghavan, K., Matsumoto, K., Hisamoto, N., Kuwahara, T., Iwatsubo, T., Moore, L., Goldstein, L., Cookson, M.,, Wolozin, B.
  • Journal Title: elegans. J. Neurosci. 29 Pages: 9210-9218
  • Peer Reviewed
• [Journal Article] J. TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP (2009)
  • Author(s): Morioka1, S., Omori, E., Kajino, T., Kajino-Sakamoto, R., Matsumoto, K.,, Ninomiya-Tsuji
  • Journal Title: Oncogene 28 Pages: 2257-2265
  • Peer Reviewed
• [Journal Article] elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation (2009)
  • Author(s): Hiatt, S.M., Duren, H.M., Shyu, Y.J., Ellis, R.E., Hisamoto, N., Matsumoto, K., Kariya, K., Kerppola, T.M.,, Hu, C-D.C.
  • Journal Title: Mol. Biol. Cell 20 Pages: 3888-3895
  • Peer Reviewed
• [Journal Article] Nemo-like kinase is involved in NGF-induced neurite outgrowth via phosphorylating MAP1B and paxillin (2009)
  • Author(s): Ishitani, T., Ishitani, S., Matsumoto, K.,, Itoh, M.
  • Journal Title: J. Neurochem 111 Pages: 1104-1118
  • Peer Reviewed
• [Journal Article] A mechanism for the suppression of IL-1-induced NF-κB activation by the protein phosphatase 2Cε-2 (2009)
  • Author(s): Henmi, T., Amano, K., Nagaura, Y., Matsumoto, K., Echigo, S., Tamura, S.,, Kobayashi,T.
  • Journal Title: Biochem. J. 423 Pages: 71-78
  • Peer Reviewed
• [Journal Article] J.M. The Germinal Center Kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline (2009)
  • Author(s): Schouest, K.R., Kurasawa, Y., Furuta, T., Hisamoto, N., Matsumoto, K.,, Schumacher
  • Journal Title: PLoS One 4
  • Peer Reviewed
• [Journal Article] LRRK2 modulates vulnerability to mitochondrial dysfunction in C.elegans. (2009)
  • Author(s): Saha, S., Guillily, M., Ferree, A., Lanceta, J., Chan, D., Ghosh, J., Hsu, C., Segal, L., Raghavan, K., Matsumoto, K., Hisamoto, N., Kuwahara, T., Iwatsubo, T., Moore, L., Goldstein, L., Cookson, M., Wolozin.B.
  • Journal Title: J.Neurosci. 29 Pages: 9210-9218
  • Peer Reviewed
• [Journal Article] TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP. (2009)
  • Author(s): Morioka, S., Omori, E., Kajino, T., Kajino-Sakamoto, R., Matsumoto, K., Ninomiya-Tsuji, J.
  • Journal Title: Oncogene 28 Pages: 2257-2265
  • Peer Reviewed
• [Journal Article] Regulation of the ERK activity duration by Sprouty contributes to dorsoventral patterning (2009)
  • Author(s): Hanafusa, H., Matsumoto, K., and Nishida, E
  • Journal Title: Nature Cell Biol 11 Pages: 106-109
  • Peer Reviewed
• [Journal Article] Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans (2008)
  • Author(s): Kuhara, A., Okumura, M., Kimata, T., Tanizawa, Y., Takano, R., Kimura, K.D., Inada, H., Matsumoto, K.,, Mori, I.
  • Journal Title: Science 320 Pages: 803-807
  • Peer Reviewed
• [Journal Article] A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance (2008)
  • Author(s): Olahova, M., Taylor, S.R., Khazaipoul, S., Wang, J., Morgan, B.A., Matsumoto, K., Blackwell, T.K.,, Veal, E.A.
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 19839-19844
  • Peer Reviewed
• [Journal Article] Hisamoto, N., Moriguchi, T., Urushiyama, S., Mitani, S., Shibuya, H., and Matsumoto, K.C. elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity (2008)
  • Author(s): Hisamoto, N., Moriguchi, T., Urushiyama, S., Mitani, S., Shibuya, H.
  • Journal Title: EMBO Rep. 9 Pages: 70-75
  • Peer Reviewed
• [Journal Article] Role of the C. elegans Shc adaptor 1 protein in the JNK signaling pathway (2008)
  • Author(s): Mizuno, T., Fujiki, K., Sasakawa, A., Hisamoto, N.,, Matsumoto, K.
  • Journal Title: Mol. Cell. Biol. 28 Pages: 7041-7049
  • Peer Reviewed
• [Journal Article] J. Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis (2008)
  • Author(s): Kajino-Sakamoto, R., Inagaki, M., Lippert, E., Akira, S., Robine, S., Matsumoto, K., Jobin, C.,, Ninomiya-Tsuji
  • Journal Title: J. Immunol. 181 Pages: 1143-1152
  • Peer Reviewed
• [Journal Article] J. TAK1 is a central mediator of NOD2 signaling in epidermal cells (2008)
  • Author(s): Kim, J.Y., Omori, E., Matsumoto, K., Nunez, G.,, Ninomiya-Tsuji
  • Journal Title: J. Biol. Chem. 283 Pages: 137-144
  • Peer Reviewed
• [Journal Article] J. TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity (2008)
  • Author(s): Omori, E., Morioka, S., Matsumoto, K.,, Ninomiya-Tsuji
  • Journal Title: J. Biol. Chem. 283 Pages: 26161-26168
  • Peer Reviewed
• [Journal Article] J. TAK1 binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling (2008)
  • Author(s): Inagaki, M., Omori, E., Kim, J-Y., Komatsu, Y., Scott, G., Ray, M.K., Yamada, G., Matsumoto, K., Mishina, Y.,, Ninomiya-Tsuji
  • Journal Title: J. Biol. Chem. 283 Pages: 33080-33086
  • Peer Reviewed
• [Journal Article] Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos (2008)
  • Author(s): Ishibashi, H., Matsumura, N., Hanafusa, H., Matsumoto, K., De Robertis, E.M.,, Kuroda, H.
  • Journal Title: Mech. Dev. 125 Pages: 58-66
  • NAID: 120000796548
  • Peer Reviewed
• [Journal Article] TAK 1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity (2008)
  • Author(s): Omori, E., Morioka, S., Matsumoto, K., and Ninomiya-Tsuji, J
  • Journal Title: J. Biol. Chem 283 Pages: 26161-26168
  • Peer Reviewed
• [Journal Article] Role of the C. elegans She adaptor 1 protein in the JNK signalingpathway (2008)
  • Author(s): Mizuno, T., Fujiki, K., Sasakawa, A., Hisamoto, N., and Matsumoto, K
  • Journal Title: Mol. Cell. Biol 28 Pages: 7041-7049
  • Peer Reviewed
• [Journal Article] C. elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity (2008)
  • Author(s): Hisamoto, N., Moriguchi, T., Urushiyama, S., Mitani, S., Shibuya, H., and Matsumoto, K.
  • Journal Title: EMBO Rep. 9 Pages: 70-75
  • Peer Reviewed
• [Journal Article] A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-g transactivation (2007)
  • Author(s): Takada1, I., Mihara, M., Suzawa, M., Ohtake, F., Kobayashi, S., Igarashi, M., Youn, M-Y., Takeyama, K., Nakamura, T., Mezaki, Y., Takezawa, S., Yogiashi, Y., Kitagawa, H., Yamada, G., Takada, S., Minami, Y., Shibuya, H., Matsumoto, K.,, Kato, S.
  • Journal Title: Nature Cell Biol. 9 Pages: 1273-1285
  • Peer Reviewed
• [Journal Article] a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins (2007)
  • Author(s): Sakaguchi-Nakashima, A., Meir, J.Y., Jin, Y., Matsumoto, K.,, Hisamoto, N. LRK-1
  • Journal Title: Curr. Biol. 17 Pages: 592-598
  • Peer Reviewed
• [Journal Article] the C. elegans P granule protein, is controlled by the JNK KGB-1 and the COP9 subunit CSN-5 (2007)
  • Author(s): Orsborn, A.M., Li, W., McEwen, T.J., Mizuno, T., Kuzmin, E., Matsumoto, K.,, Bennett, K.L. GLH-1
  • Journal Title: Development 134 Pages: 3383-3392
  • Peer Reviewed
• [Journal Article] TAK1 MAPKKK mediates TGF-β signaling by targeting SnoN oncoprotein for degradation (2007)
  • Author(s): Kajino, T., Omori, E., Ishii, S., Matsumoto, K.,, Ninomiya-Tsuji, J.
  • Journal Title: J. Biol. Chem. 282 Pages: 9475-9481
  • Peer Reviewed
• [Journal Article] Osmotic stress blocks NF-κB-dependent inflammatory responses by inhibiting ubiquitination of IκB (2007)
  • Author(s): HuangFu, W-C., Matsumoto, K.,, Ninomiya-Tsuji, J.
  • Journal Title: FEBS Lett. 581 Pages: 5549-5554
  • Peer Reviewed
• [Journal Article] LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins. (2007)
  • Author(s): Sakaguchi-Nakashima, A., Meir, J. Y., Jin, Y., Matsumoto, K., and Hisamoto, N.
  • Journal Title: Curr. Biol. 17 Pages: 592-598
  • Peer Reviewed
• [Journal Article] TAK1 MAPKKK mediates TGF-β signaling by targeting SnoN oncoprotein for degradation. (2007)
  • Author(s): Kajino, T., Omori, E., Ishii, S., Matsumoto, K., and Ninomiya-Tsuji, J.
  • Journal Title: J. Biol. Chem. 282 Pages: 9475-9481
  • Peer Reviewed
• [Journal Article] TAK1 MAPKKK mediates TGF-β signaling by targeting SnoN oncoprotein fo degradation (2007)
  • Author(s): Kajino, T., et al.
  • Journal Title: J. Biol. Chem. 282 Pages: 9475-9481
• [Journal Article] The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway (2006)
  • Author(s): Thiefes, A., Wolf, A., Doerrie, A., Grassl, G.A., Matsumoto. K., Autenrieth, I., Bohn, E., Sakurai, H., Niedenthal, R., Resch, R.,, Kracht, M.
  • Journal Title: EMBO Rep. 7 Pages: 838-844
  • Peer Reviewed
• [Journal Article] J. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-κB. (2006)
  • Author(s): Uemura, N., Kajino, T., Sanjo, H., Sato, S., Akira, A., Matsumoto, K.,, Ninomiya-Tsuj
  • Journal Title: J. Biol. Chem. 281 Pages: 7863-7872
  • Peer Reviewed
• [Journal Article] J. TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis (2006)
  • Author(s): Omori, E., Matsumoto, K., Sanjo, H., Sato, S., Akira, S., Smart, R.C.,, Ninomiya-Tsuji
  • Journal Title: J. Biol. Chem. 281 Pages: 19610-19617
  • Peer Reviewed
• [Journal Article] J. Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kB activation: TAO2 regulates TAK1 pathways (2006)
  • Author(s): HuangFu, W-C., Omori, E., Akira, S., Matsumoto, K.,, Ninomiya-Tsuji
  • Journal Title: J. Biol. Chem. 281 Pages: 28802-28810
  • Peer Reviewed
• [Journal Article] J. Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling Pathway (2006)
  • Author(s): Kajino, T., Ren, H., Iemura, S., Natsume, T., Stefansson, B., Brautigan, D.L., Matsumoto, K.,, Ninomiya-Tsuji
  • Journal Title: J. Biol. Chem. 281 Pages: 39891-39896
  • Peer Reviewed
• [Journal Article] Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans (2006)
  • Author(s): Inada, H., Ito, H., Satterlee, J., Sengupta, P., Matsumoto, K.,, Mori, I.
  • Journal Title: Genetics 172 Pages: 2239-2252
  • Peer Reviewed
• [Journal Article] TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-κB (2006)
  • Author(s): Uemura, N., et al.
  • Journal Title: J. Biol. Chem. 281 Pages: 7863-7872
• [Journal Article] TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis (2006)
  • Author(s): Omori, E., et al.
  • Journal Title: J. Biol. Chem. 281 Pages: 19610-19617
• [Journal Article] Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability (2005)
  • Author(s): Ishitani, T., Matsumoto, K., Chitnis, A.B.,, Itoh, M.
  • Journal Title: Nature Cell Biol. 7 Pages: 1106-1112
  • Peer Reviewed
• [Journal Article] ROS-dependent activation of TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity (2005)
  • Author(s): Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K.,, Ichijo, H.
  • Journal Title: Nature Immunol 6 Pages: 587-592
  • Peer Reviewed
• [Journal Article] Essential function of the kinase TAK1 in innate and adaptive immune responses (2005)
  • Author(s): Sato, S., Sanjo, H., Takeda, K., Ninomiya-Tsuji, J., Yamamoto, M., Kawai, T., Matsumoto, K., Takeuchi, O.,, Akira, S.
  • Journal Title: Nature Immunol 6 Pages: 1087-1095
  • Peer Reviewed
• [Journal Article] The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response (2005)
  • Author(s): Inoue, H., Hisamoto, N., An, J.H., Oliveira, R.P., Nishida, E., Blackwell, T.K.,, Matsumoto, K.
  • Journal Title: Genes Dev. 19 Pages: 2278-2283
  • Peer Reviewed
• [Journal Article] but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo (2005)
  • Author(s): Jae-Hyuck Shim, J-H., Xiao, C., Paschal, A.E., Bailey, S.T., Rao, P., Hayden, M.S., Lee, K-Y., Bussey, C., Steckel, M., Tanaka, N., Yamada, G., Akira, S., Matsumoto, K.,, Ghosh, S. TAK1
  • Journal Title: Genes Dev. 19 Pages: 2668-2681
  • Peer Reviewed
• [Journal Article] STAT3 enhances TAK1-dependent NLK activation for its Ser727 phosphorylatgion by acting as a scaffold specifically in IL-6 signaling (2005)
  • Author(s): Kojima, H., Sasaki, T., Ishitani, T., Iemura, S., Zhao, H., Kaneko, S., Kunimoto, H., Natsume, T., Matsumoto, K.,, Nakajima, K.
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 4524-4529
  • Peer Reviewed
• [Journal Article] Regulation of the C. elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3 (2005)
  • Author(s): An, J.H., Vranas, K., Lucke, M., Inoue, H., Hisamoto, N., Matsumoto, K.,, Blackwell, T.K.
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 16275-16280
  • Peer Reviewed
• [Journal Article] The C. elegans UNC-14 RUN domain protein binds to the Kinesin-1/UNC-16 complex and regulates synaptic vesicle localization (2005)
  • Author(s): Sakamoto, R., Byrd, D.T., Brown, H.M., Hisamoto, N., Matsumoto, K.,, Jin, Y.
  • Journal Title: Mol. Biol. Cell 16 Pages: 483-496
  • Peer Reviewed
• [Journal Article] WNK1 regulates phosphorylation of cation-chloride-coupled kinases, SPAK and OSR1 (2005)
  • Author(s): Moriguchi, T., Urushiyama, S., Hisamoto, N., Iemura, S., Uchida, S., Natsume, T., Matsumoto, K.,, Shibuya, H.
  • Journal Title: J. Biol. Chem. 280 Pages: 42685-42693
  • Peer Reviewed
• [Journal Article] TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway (2005)
  • Author(s): Kishida, S., Sanjo, H., Akira, S., Matsumoto, K.,, Ninomiya-Tsuji, J.
  • Journal Title: Genes Cells 10 Pages: 447-454
  • Peer Reviewed
• [Journal Article] The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei (2005)
  • Author(s): Kondo M., Yanase. S., Ishii, T., Hartman, P.S., Matsumoto, K.,, Ishii, N.
  • Journal Title: Mech. Ageing Dev. 126 Pages: 642-647
  • Peer Reviewed
• [Journal Article] Essential function of the kinase TAK1 in innate and adaptive immune responses. (2005)
  • Author(s): Sato, S., et al.
  • Journal Title: Nature Immunol. 6 Pages: 1087-1095
• [Journal Article] TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. (2005)
  • Author(s): Jae-Hyuck Shim, et al.
  • Journal Title: Genes Dev. 19 Pages: 2668-2681
• [Presentation] ROCOファミリーキナーゼLRRK1によるEGFR細胞内トラフィック制御 (2009)
  • Author(s): 花房洋、松本邦弘
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] LRRK1とARAP1によるEGFR細胞内トラフィックの制御 (2009)
  • Author(s): 石川光紀、花房洋、渋谷浩司、松本邦弘
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 松本邦弘NudCは、LRRK1-EGFR複合体とDyneinをつなぐアダプターとして機能し、EGFRの細胞内トラフィックを制御する (2009)
  • Author(s): 慶田城迅、花房洋、松本邦弘
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 細胞質分裂時におけるROCOファミリーキナーゼLRRK1の機能解析 (2009)
  • Author(s): 手塚基弘、花房洋、松本邦弘
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] LRRK 1はESCRT-0複合体と相互作用することでEGFR細胞内トラフィックを制御している (2008)
  • Author(s): 花房洋、石川光紀、渋谷浩司、駒田雅之、松本邦弘
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] LRRK1はGrb2を介したEGFRエンドサイトーシスを制御する (2007)
  • Author(s): 花房洋、石川光紀、後藤美樹、家村俊一郎、夏目徹、渋谷浩司、松本邦弘
  • Organizer: 第30回日本分子生物学会年会 第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Remarks]
  • URL: http://bunshi3.bio.nagoya-u.ac.jp/~bunshi6/matsumoto_japanese/index.html