The core unit supporting research, communication, network and young scientists in the cancer research field

• Project/Area Number: 17012024
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Japanese Foundation For Cancer Research
• Principal Investigator: NAKAMURA Takuro Japanese Foundation For Cancer Research, 発がん研究部, 部長 (00180373)
• Co-Investigator(Kenkyū-buntansha): IMAMURA Takeshi 財団法人癌研究会, 癌研究所生化学部, 部長 (70264421) ; MIYAZONO Kouhei 東京大学, 大学院・医学系研究科, 教授 (90209908) ; ISHIKAWA Fuyuki 京都大学, 大学院・生命科学研究科, 教授 (30184493) ; MATUDA Michiyuki 京都大学, 大学院・医学研究科, 教授 (10199812)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥250,000,000 (Direct Cost: ¥250,000,000); Fiscal Year 2009: ¥46,900,000 (Direct Cost: ¥46,900,000); Fiscal Year 2008: ¥46,900,000 (Direct Cost: ¥46,900,000); Fiscal Year 2007: ¥46,900,000 (Direct Cost: ¥46,900,000); Fiscal Year 2006: ¥46,900,000 (Direct Cost: ¥46,900,000); Fiscal Year 2005: ¥62,400,000 (Direct Cost: ¥62,400,000)
• Keywords: 国際交流 / 若手支援 / 広報支援 / 青少年育成 / 広報活動

Research Abstract

The core unit (Chukaku Kyoten) supported researches in the priority area for cancer research. The unit consisted of committees for support of young scientists, international affairs, public relations and youth education, and promoted research activities of young scientists, traveling of researchers to abroad, international workshop, publication and internet service of research activities and youth education for cancer.

Research Products

• [Journal Article] BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its muclear body. (2008)
  • Author(s): Kuwata T, Nakamura T.
  • Journal Title: Genes Cells 13 Pages: 931-940
  • Peer Reviewed
• [Journal Article] Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. (2008)
  • Author(s): Fukunaga E, Inoue Y, komiya S, Horiguchi K, Goto K, Saitoh M, MiyazawaK, Koinuma D, Hanyu A, Imamura T,
  • Journal Title: J Biol Chem 283 Pages: 35660-35667
  • Peer Reviewed
• [Journal Article] An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-b signaling. (2008)
  • Author(s): Ikushima H. Komuro A, IsogayaK, Shinozaki M, Hellman U, Miyazawa K, Miyazono K.
  • Journal Title: EMBO J 27 Pages: 2955-2965
  • Peer Reviewed
• [Journal Article] Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. (2008)
  • Author(s): Miyoshi T, Kanoh J, Saito M, Ishikawa F.
  • Journal Title: Science 320 Pages: 1341-1344
  • Peer Reviewed
• [Journal Article] Imaging of Rab5 activity identifies essential regulators for phagosome maturation. (2008)
  • Author(s): Kitano M, Nakaya M, Nakamura T. Nagata S. Matsuda M.
  • Journal Title: Nature 453 Pages: 214-245
  • Peer Reviewed
• [Journal Article] Pitx2 prevents osteoblastic trans-differentiation of myoblasts by bone morphogenetic proteins. (2008)
  • Author(s): Hayashi M, Maeda S, Aburatani H, et. al.
  • Journal Title: J Biol Chem 283 Pages: 565-571
  • Peer Reviewed
• [Journal Article] Identification of candidate cooperative genes of the Apc mutation in transformation of the colon epithelial cell by retroviral insertional mutagenesis. (2008)
  • Author(s): Tanaka M, Jin G, Yamazaki Y, et. al.
  • Journal Title: Cancer Sci. 99 Pages: 979-985
  • Peer Reviewed
• [Journal Article] Tribl and Evil cooperate with Hoxa and Meisl in myeloid leukemogenesis. (2007)
  • Author(s): Jin G, Yamazaki Y, Takuwa M, et. al.
  • Journal Title: Blood 109 Pages: 3998-4005
  • Peer Reviewed
• [Journal Article] An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of NGF-stimulated PC12 cells. (2007)
  • Author(s): Aoki K, Nakamura T, Inoue T, et. al.
  • Journal Title: J Cell Biol 177 Pages: 817-827
  • Peer Reviewed
• [Journal Article] Transforming growth factor-b promotes survival of mammary carcinoma cells through induction of anti-apoptotic transcription factor DEC1. (2007)
  • Author(s): Ehata S, Hanyu A, Hayashi M, et. al.
  • Journal Title: Cancer Res. 67 Pages: 9694-9703
  • Peer Reviewed
• [Journal Article] Improvement of cancer-targeting therapy using nanocarriers for intractable solid tumors by inhibition of TGF-6 signaling. (2007)
  • Author(s): Kano M.R., Bae Y., Mivazono K.et al.
  • Journal Title: Proc Natl Acad Sci USA 104・9 Pages: 3460-3465
• [Journal Article] Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. (2006)
  • Author(s): Kawamura-Saito M., Yamazaki Y., Kaneko K., Kawaguchi N., Nakamura T.et al.
  • Journal Title: Hum Mot Genet 15・13 Pages: 2125-2137
• [Journal Article] CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation. (2006)
  • Author(s): Shirakawa K., Maeda M., Gotoh T., Imamura T.et al.
  • Journal Title: Mol Cell Biol 26・16 Pages: 6105-6116
• [Journal Article] Loss of Linker Histone H1 in Cellular Senescence. (2006)
  • Author(s): Funayama R., Saito M., Tanobe H., Ishikawa F.
  • Journal Title: J. Cell Biol 175・6 Pages: 869-880
• [Journal Article] The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf. (2006)
  • Author(s): Terai K., Matsuda M.
  • Journal Title: EMBO J 25・15 Pages: 3556-3564
• [Journal Article] Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase. (2006)
  • Author(s): Nishiyama A, Muraki K, Saito M, Ohsumi K, Kishimoto T, Ishikawa F.
  • Journal Title: EMBO J 25・3 Pages: 575-584
• [Journal Article] Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. (2005)
  • Author(s): Iwasaki M, Kuwata T, Yamazaki Y, Jenkins NA, Copeland NG, Osato M, Ito Y, Kroon E, Sauvageau G, Nakamura T.
  • Journal Title: Blood 105 Pages: 784-793
• [Journal Article] EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12). (2005)
  • Author(s): Yamaguchi S, Yamazaki Y, Ishikawa Y, Kawaguchi N, Mukai H, Nakamura T
  • Journal Title: Chromosomes Cancer 43 Pages: 217-222
• [Journal Article] The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. (2005)
  • Author(s): Tojo M, Hamashima Y, Hanyu A, Kajimoto T, Saitoh M, Miyazono K, Node M, Imamura T.
  • Journal Title: Cancer Sci 96 Pages: 791-800
• [Journal Article] Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. (2005)
  • Author(s): Azuma H, Ehata S, Miyazaki H, Watabe T, Miyazono K. et al.
  • Journal Title: J.Natl.Cancer Inst 97・23 Pages: 1734-1746
• [Journal Article] Dynamics of the RAS/ERK map kinase cascade as monitored by fluorescence probes.
  • Author(s): Fujioka A, Terai K, Itoh RE, Aoki K, Nakamura T, Kuroda S, Nishida E, Matsuda M.
  • Journal Title: J Biol Chem (In press)
• [Presentation] Molecular mechanisms of Hoxa9/Meisl-induced myeloid leukemogenes is (2007)
  • Author(s): 中村卓郎
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-10-04
• [Remarks]
  • URL: http://gantoku3.umin.jp/
• [Remarks]
  • URL: http://gantoku3.umin.jp/about/chukaku.html
• [Remarks]
  • URL: http://gantoku3.umin.jp/about/chukaku.html
• [Remarks]
  • URL: http://gantoku3.umin.jp/about/chukaku.html
• [Patent(Industrial Property Rights)] TGF-βシグナル阻害剤と抗腫瘍剤の組み合せ使用 (2006)
  • Inventor(s): 宮園浩平 他7名
  • Industrial Property Number: 2006-024843
  • Filing Date: 2006-02-01