Molecular mechanisms of multi-step leukemogenesis in Down syndrome
Project/Area Number |
17013004
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Hirosaki University |
Principal Investigator |
ITO Etsuro Hirosaki University, 大学院・医学研究科, 教授 (20168339)
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Co-Investigator(Kenkyū-buntansha) |
土岐 力 弘前大学, 大学院・医学研究科, 講師 (50195731)
|
Project Period (FY) |
2005 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥47,000,000 (Direct Cost: ¥47,000,000)
Fiscal Year 2009: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2008: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2007: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2006: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2005: ¥9,400,000 (Direct Cost: ¥9,400,000)
|
Keywords | ダウン症候群 / 白血病 / 転写因子 / GATA1 / 21番染色体 / TMD / WL-DS / BACH1 / STAT3 / KIT / JAK3 / 急性巨核球性白血病 / AML1 / RUNX1 / AMKL |
Research Abstract |
To understand the mechanism of leukemogensis in Down syndrome, we investigate the genes on chromosome 21 and identified ERG, RUNX1 and BACH1 as the candidates of the causative genes. JAK3 activating mutations were identified in about 10% of preleukemia (TMD) in Down syndrome. GATA1 mutations affected the expression levels of GATA1s protein. GATA1s low mutations in TMD were significantly associated with a risk of progression to acute megakaryoblastic leukemia and lower WBC counts.
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Report
(6 results)
Research Products
(38 results)
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[Journal Article] Array-based genomic resequencing of human leukemia.2010
Author(s)
Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, Mano H.
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Journal Title
Oncogene (Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia.2010
Author(s)
Konno Y, Toki T, Tandai S, Xu G, Wang RN, Terui K, Ohoga S, Hara T, Hama A, Kojima S, Hasegawa D, Kosaka Y, Yanagisawa R, Koike K, Kanai R, Imai T, Hongo T, Park MJ, Sugita K, Ito E.
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Journal Title
Haematologica (Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Transgenic expression of Bach1 transcription factor results in megakaryocytic impairment.2005
Author(s)
Toki T, Katsuoka F, Kanezaki R, Xu G, Kurotaki H, Sun J, Kamio T, Watanabe S, Tandai S, Terui K, Yagihashi S, Komatsu N, Igarashi K, Yamamoto M, Ito E.
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Journal Title
Blood 105巻
Pages: 3100-3108
Related Report
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[Journal Article] Transgenic expression of Bach1 transcription factor results in megakaryocytic impairment.2005
Author(s)
Toki T, Katusuoka F, Kanezaki R, Xu G, Kurotaki H, Sun J, Kamio T, Watanabe S, Tandai S, Terui K, Yagihashi S, Komatsu N, Igarashi K, Yamamoto M, Ito E.
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Journal Title
Blood 105
Pages: 3100-3108
Related Report
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