| Budget Amount *help |
¥384,800,000 (Direct Cost: ¥384,800,000)
Fiscal Year 2009: ¥77,500,000 (Direct Cost: ¥77,500,000)
Fiscal Year 2008: ¥77,500,000 (Direct Cost: ¥77,500,000)
Fiscal Year 2007: ¥77,500,000 (Direct Cost: ¥77,500,000)
Fiscal Year 2006: ¥77,500,000 (Direct Cost: ¥77,500,000)
Fiscal Year 2005: ¥74,800,000 (Direct Cost: ¥74,800,000)
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| Research Abstract |
In this study, we have developed several mouse models simulating the process of human carcinogenesis induced by the activation of oncogenic signaling such as Wnt and Sonic hedgehog signaling. Through the analysis of tumor formation in these mouse models, we could have successfully elucidated the molecular mechanisms of carcinogenesis. Functional roles of cancer related genes elucidated through this analysis could suggest strong candidates for novel molecular targets of human cancer therapy.
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