Functional analysis of a tumor suppressor gene PTEN in vivo
Project/Area Number |
17013014
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Kyushu University (2008-2009) Akita University (2005-2007) |
Principal Investigator |
SUZUKI Akira Kyushu University, 生体防御医学研究所, 教授 (10311565)
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Project Period (FY) |
2005 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥47,000,000 (Direct Cost: ¥47,000,000)
Fiscal Year 2009: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2008: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2007: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2006: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2005: ¥9,400,000 (Direct Cost: ¥9,400,000)
|
Keywords | 遺伝子改変動物 / 分子腫瘍学 / 疾患モデル動物2 / PTEN / PI3K / 膵ベータ細胞 / 肝臓 / 皮膚 / T細胞 / PI3キナーゼ / 癌抑制遺伝子 / 脂質 / ホスファターゼ / 色素上皮細胞 / P13キナーゼ / 肺胞上皮細胞 / NKT細胞 / 膀胱 / ボスファターゼ / 血管内皮細胞 / 糖尿病 |
Research Abstract |
We analyzed the functions of PTEN/PI3kinase pathway by generating PTEN tissue specific knock-out mice. Results show that PTEN deficiency causes various cancers and non-cancerous diseases. Therefore, these mutant mice have become attractive and powerful tools to analyze these diseases and to develop new therapeutic methods.
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Report
(6 results)
Research Products
(129 results)
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[Journal Article] The PtdIns(3, 4)P2-phosphatase INPP4A is a suppressor of excitotoxic neuronal death2010
Author(s)
Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davis M, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T
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[Journal Article] Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins2008
Author(s)
Qui W, Federico L, Naples M, Avramoglu RK, Meshkani R, Zhang J, Tsai J, Hussain M, Iqbai J, Kontos CD, Horie Y, Suzuki A, Adeli K
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Journal Title
HEPATOLOGY Vol.48(6)
Pages: 1799-1809
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Peer Reviewed
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[Journal Article] Pten deficiency in melanocytes results in resistance to hair graying and susceptiblity to carcinogen-induced melanomagenesis2008
Author(s)
Inoue-Narita T, Hamada K, Sasaki T, Hatakeyama S, Fujita S, Kawahara K, Sasaki M, Kishimoto H, Eguchi S, Kojima I, Beermann F, Kimura T, Osawa M, Itami S, Mak TW, Nakano T, Manabe M, Suzuki A
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Journal Title
CANCER RESAERCH Vol.68(14)
Pages: 5760-8
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[Journal Article] Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages2008
Author(s)
Kuroda S, Nishio M, Sasaki T, Horie Y, Kawahara K, Sasaki M, Natsui M, Matozaki T, Tezuka H, Ohteki T, Forster I, Mak TW, Nakano T, Suzuki A
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Journal Title
EUROPEAN JOURNAL OF IMMUNOLOGY Vol.38(5)
Pages: 1331-40
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[Journal Article] Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation2007
Author(s)
Plum L, Rother E, Munzberg H, Wunderlich FT, Morgan DA, Hampel B, Shanabrough M, Janoschek R, Konner AC, Alber J, Suzuki A, Krone W, Horvath TL, Rahmouni K, Bruning JC
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Journal Title
CELL METABOLISM Vol.6(6)
Pages: 431-445
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[Journal Article] Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas2007
Author(s)
Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Sasaki M, Nishio M, Yajima N, Hamada K, Horie Y, Kubo H, Mak TW, Nakano T, Nakazato M, Suzuki A
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Journal Title
JOURNAL OF CLINICAL INVESTIGATION Vol.117(10)
Pages: 2929-40
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[Journal Article] The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells2007
Author(s)
Kishimoto H, Ohteki T, Yajima N, Kawahara K, Natsui M, Kawarasaki S, Hamada K, Horie Y, Kubo Y, Arase S, Taniguchi M, Vanhaesebroeck B, Mak TW, Nakano N, Koyasu S, Sasaki T, Suzuki A
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Journal Title
BLOOD Vol.109(8)
Pages: 3316-24
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[Journal Article] Control of Cell Polarity and motility byPI(3, 4, 5)P3 phosphatase2007
Author(s)
Nishio M, Watanabe K, Sasaki J, Taya C, Takasuga S, Iizuka R, Bella T, Yamazaki M, Watanabe H, Kuroda S, Itoh R, Forster I, Mak TW, Kanaho Y, Yonehara H, Penninger JM, Suzuki A(equal last author), Sasaki T.
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Journal Title
SHIP NATURE CELL BIOLOGY Vol.9(1)
Pages: 36-44
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[Journal Article] Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients2006
Author(s)
Tsuruta H, Kishimoto H, Sasaki T, Horie Y, Natsui M, Shibata Y, Hamada K, Yajima N, Kawahara K, Sasaki M, Tsuchiya N, Enomoto K, Mak TW, Nakano T, Habuchi T, Suzuki A
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Journal Title
CANCER RESEARCH Vol.66(17)
Pages: 8389-96
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[Journal Article] Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN2006
Author(s)
Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, McCaig CD, Penninger JM
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Journal Title
NATURE Vol.442(7101)
Pages: 457-60
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[Journal Article] Enhanced PIP3 Signaling in POMC Neurons Causes Neuronal Silencing via KATP Channel Activation and Leads to Diet-sensitive Obesity2006
Author(s)
Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Munzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Bruning JC
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Journal Title
JOURNAL OF CLINICAL INVESTIGATION Vol.116(7)
Pages: 1886-901
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Peer Reviewed
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[Journal Article] Essential role of Pten in body size determination and pancreatic beta cell homeostasis in vivo2006
Author(s)
Nguyen KT, Tajmir P, Lin CH, Liadis N, Zhu XD, Eweida M, Tolasa-Karaman G, Cai F, Wang R, Kitamura T, Belsham DD, Wheeler MB, Suzuki A, Mak TW, Woo M
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Journal Title
MOLECULAR AND CELLULAR BIOLOGY Vol.26(12)
Pages: 4511-8
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Peer Reviewed
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[Journal Article] Hepatocic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge2006
Author(s)
Sato W, Horie Y, Kataoka E, Ohshima S, Dohmen T, Iizuka M, Sasaki J, Sasaki T, Hamada K, Kishimoto H, Suzuki A, Watanabe S
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Journal Title
HEPATOLOGY RESEARCH Vol.34(4)
Pages: 256-65
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[Journal Article] The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis2005
Author(s)
Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Hasegawa G, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A
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Journal Title
GENES AND DEVELOPMENT Vol.19(17)
Pages: 2054-2065
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[Journal Article] Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I alpha2005
Author(s)
Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T, Miyazaki H, Watanabe H, Iizuka R, Kubo S, Murata S, Chiba T, Maehama T, Hamada K, Kishimoto H, Frohman MA, Tanaka K, Penninger JM, Yonekawa H, Suzuki A, Kanaho Y
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Journal Title
JOURNAL OF EXPERIMENTAL MEDICINE Vol.201(6)
Pages: 859-870
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[Journal Article] Muscle-specific Pten deletion protects against insulin resistance and diabetes2005
Author(s)
Wijesekara N, Konrad D, Edeida M, Jefferies C, Liadis N, Giacca A, Crockower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M
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Journal Title
MOLECULAR AND CELLULAR BIOLOGY Vol.25(3)
Pages: 1135-1145
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Peer Reviewed
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[Presentation]2005
Author(s)
黒田聖子, 岸本恕征, 佐々木雄彦, 仲野徹, 鈴木聡
Organizer
日本免疫学会学術集会
Place of Presentation
横浜
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[Presentation] Mechanism of steatohepatitis in hepatocyte-specific Pten deficient mice, an animal model of nonalcoholic steatohepatitis2005
Author(s)
Horie Y, Kataoka E, Ohshima S, Sato W, Dohmen T, Goto T, Takeuchi S, Iizuka M, Suzuki A, Watanabe S
Organizer
第56回アメリカ肝臓病学会(AASLD:American Association for the Study of Liver Disease)
Place of Presentation
サンフランシスコ
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