Functional analysis of a tumor suppressor gene PTEN in vivo

• Project/Area Number: 17013014
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyushu University (2008-2009); Akita University (2005-2007)
• Principal Investigator: SUZUKI Akira Kyushu University, 生体防御医学研究所, 教授 (10311565)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥47,000,000 (Direct Cost: ¥47,000,000); Fiscal Year 2009: ¥9,400,000 (Direct Cost: ¥9,400,000); Fiscal Year 2008: ¥9,400,000 (Direct Cost: ¥9,400,000); Fiscal Year 2007: ¥9,400,000 (Direct Cost: ¥9,400,000); Fiscal Year 2006: ¥9,400,000 (Direct Cost: ¥9,400,000); Fiscal Year 2005: ¥9,400,000 (Direct Cost: ¥9,400,000)
• Keywords: 遺伝子改変動物 / 分子腫瘍学 / 疾患モデル動物2 / PTEN / PI3K / 膵ベータ細胞 / 肝臓 / 皮膚 / T細胞 / PI3キナーゼ / 癌抑制遺伝子 / 脂質 / ホスファターゼ / 色素上皮細胞 / P13キナーゼ / 肺胞上皮細胞 / NKT細胞 / 膀胱 / ボスファターゼ / 血管内皮細胞 / 糖尿病

Research Abstract

We analyzed the functions of PTEN/PI3kinase pathway by generating PTEN tissue specific knock-out mice. Results show that PTEN deficiency causes various cancers and non-cancerous diseases. Therefore, these mutant mice have become attractive and powerful tools to analyze these diseases and to develop new therapeutic methods.

Research Products

• [Journal Article] The PtdIns(3, 4)P2-phosphatase INPP4A is a suppressor of excitotoxic neuronal death (2010)
  • Author(s): Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davis M, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T
  • Journal Title: NATURE (in press)
  • Peer Reviewed
• [Journal Article] Nod-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo (2010)
  • Author(s): Asano J, Tada H, Onai N, Sato T, Horie Y, Fujimoto Y, Fukase K, Suzuki A, Mak TW, Ohteki T
  • Journal Title: JOURNAL OF IMMUNOLOGY Vol.184(2) Pages: 736-745
  • Peer Reviewed
• [Journal Article] The PtdIns(3,4)P2-Phosphatase INPP4A is a Suppressor of Excitotoxic Neuronal Death (2010)
  • Author(s): Sasaki J, et al
  • Journal Title: Nature (In press)
  • Peer Reviewed
• [Journal Article] Nod-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo (2010)
  • Author(s): Asano J, et al
  • Journal Title: J.Immunol 184 Pages: 736-745
  • Peer Reviewed
• [Journal Article] PTEN deletion and concomitant c-Myc activation does not lead to tumor formation in pancreatic beta cells (2009)
  • Author(s): Radziszewska A, Choi D, Nguyen KT, Schroer SA, Tajmir P, Wang L, Suzuki A, Mak TW, Evan GI, Woo M
  • Journal Title: JOURNAL OF BIOLOGICAL CHEMISTRY Vol.284(5) Pages: 2917-2922
  • Peer Reviewed
• [Journal Article] Sex difference in the liver of hepatocyte-specific Pten-deficient mice : A model of nonalcoholic steatohepatitis (2009)
  • Author(s): Anezaki Y, et al
  • Journal Title: Hepatol Res 39 Pages: 609-618
  • Peer Reviewed
• [Journal Article] Mammalian phosphoinositide kinases and phosphatases (2009)
  • Author(s): Sasaki T, et al
  • Journal Title: Prog Lipid Res. 48 Pages: 307-343
  • Peer Reviewed
• [Journal Article] Induction of gene encoding FABP4 in Pten-null keratinocytes. (2009)
  • Author(s): Tsuda M
  • Journal Title: FEBS lett 583 Pages: 1319-1322
  • Peer Reviewed
• [Journal Article] Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins (2008)
  • Author(s): Qui W, Federico L, Naples M, Avramoglu RK, Meshkani R, Zhang J, Tsai J, Hussain M, Iqbai J, Kontos CD, Horie Y, Suzuki A, Adeli K
  • Journal Title: HEPATOLOGY Vol.48(6) Pages: 1799-1809
  • Peer Reviewed
• [Journal Article] The role of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey (2008)
  • Author(s): Knobbe CB, Lapin V, Suzuki A, Mak TW
  • Journal Title: ONCOGENE Vol.27(41) Pages: 5398-5415
  • Peer Reviewed
• [Journal Article] Pten deficiency in melanocytes results in resistance to hair graying and susceptiblity to carcinogen-induced melanomagenesis (2008)
  • Author(s): Inoue-Narita T, Hamada K, Sasaki T, Hatakeyama S, Fujita S, Kawahara K, Sasaki M, Kishimoto H, Eguchi S, Kojima I, Beermann F, Kimura T, Osawa M, Itami S, Mak TW, Nakano T, Manabe M, Suzuki A
  • Journal Title: CANCER RESAERCH Vol.68(14) Pages: 5760-8
  • Peer Reviewed
• [Journal Article] Partial deletion of PTEN in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone (2008)
  • Author(s): Choi D, Nguyen KT, Wang L, Schroer S, Suzuki A, Mak TW, Woo M
  • Journal Title: ENDOCRINOLOGY Vol.149(9) Pages: 4382-6
  • Peer Reviewed
• [Journal Article] Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages (2008)
  • Author(s): Kuroda S, Nishio M, Sasaki T, Horie Y, Kawahara K, Sasaki M, Natsui M, Matozaki T, Tezuka H, Ohteki T, Forster I, Mak TW, Nakano T, Suzuki A
  • Journal Title: EUROPEAN JOURNAL OF IMMUNOLOGY Vol.38(5) Pages: 1331-40
  • Peer Reviewed
• [Journal Article] Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice (2008)
  • Author(s): Xue L, Nolla H, Suzuki A, Mak TW, Winoto A
  • Journal Title: PROCEEDING OF NATIONAL ACADEMY OF SCIENCE USA Vol.105(6) Pages: 2022-2027
  • Peer Reviewed
• [Journal Article] Portrait of PTEN:Messages from Mutant Mice (2008)
  • Author(s): Suzuki A, Nakano T, Mak TW, Sasaki T
  • Journal Title: CANCER SCIENCE Vol.9(2) Pages: 209-13
  • Peer Reviewed
• [Journal Article] Pten deficiency in melanocytes results in resistance to hair graying and suscentiblitv to carcinogen-induced melanomanenesis (2008)
  • Author(s): Inoue-Narita, ら
  • Journal Title: CANCER RESAERCH 68 Pages: 5760-5768
  • Peer Reviewed
• [Journal Article] Effective clearance of intracellular Leishmania major in vivo requires Pten in macrouhages (2008)
  • Author(s): Kuroda, ら
  • Journal Title: EUROPEAN JOURNAL OF IMMUNOLOGY 38 Pages: 1331-1340
  • Peer Reviewed
• [Journal Article] Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins (2008)
  • Author(s): Qui, ら
  • Journal Title: HEPATOLOGY 48 Pages: 1799-1809
  • Peer Reviewed
• [Journal Article] The role of PTEN in development, physiology and tumorigenesis in mouse models : a tissue-by-tissue survey (2008)
  • Author(s): Knobbe, ら
  • Journal Title: ONCOGENE 27 Pages: 5398-5415
  • Peer Reviewed
• [Journal Article] Partial deletion of PTEN in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone (2008)
  • Author(s): Choi, ら
  • Journal Title: ENDOCRINOLOGY 149 Pages: 4382-4386
  • Peer Reviewed
• [Journal Article] Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice (2008)
  • Author(s): Xue, ら
  • Journal Title: PROCEEDING OF NATIONAL ACADEMY OF SCIENCE USA 105 Pages: 2022-2027
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice (2008)
  • Author(s): Ishh, ら
  • Journal Title: JOURNAL OF HEPATOLOGY 50 Pages: 562-571
  • Peer Reviewed
• [Journal Article] 癌抑制遺伝子PTEN異常による各種疾患-PTEN欠損マウスが教えてくれたもの- (2008)
  • Author(s): 河原, ら
  • Journal Title: 生化学 80 Pages: 1017-1025
  • Peer Reviewed
• [Journal Article] 血管内皮細胞におけるPTEN/PI3キナーゼシグナル経路の役割 (2008)
  • Author(s): 濱田, ら
  • Journal Title: 細胞工学 27 Pages: 480-485
  • Peer Reviewed
• [Journal Article] Normal development is an integral part of tumorigenesis in Tcell-specific PTEN-deficient mice. (2008)
  • Author(s): Xue, L, et. al.
  • Journal Title: Peoc. Natl. Acad. Sci. USA 105 Pages: 2022-2027
  • Peer Reviewed
• [Journal Article] Portrait of PTEN:messages from mutant mice. (2008)
  • Author(s): Suzuki, et. al.
  • Journal Title: Cancer Sci. 99 Pages: 209-213
  • Peer Reviewed
• [Journal Article] Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation (2007)
  • Author(s): Plum L, Rother E, Munzberg H, Wunderlich FT, Morgan DA, Hampel B, Shanabrough M, Janoschek R, Konner AC, Alber J, Suzuki A, Krone W, Horvath TL, Rahmouni K, Bruning JC
  • Journal Title: CELL METABOLISM Vol.6(6) Pages: 431-445
  • Peer Reviewed
• [Journal Article] Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas (2007)
  • Author(s): Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Sasaki M, Nishio M, Yajima N, Hamada K, Horie Y, Kubo H, Mak TW, Nakano T, Nakazato M, Suzuki A
  • Journal Title: JOURNAL OF CLINICAL INVESTIGATION Vol.117(10) Pages: 2929-40
  • Peer Reviewed
• [Journal Article] Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models (2007)
  • Author(s): Sasaki T, Sasaki J, Watanabe K, Suzuki A
  • Journal Title: BIOCHEMICAL SOCIETY TRANSACTION Vol.35(Pt2) Pages: 215-8
  • Peer Reviewed
• [Journal Article] The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells (2007)
  • Author(s): Kishimoto H, Ohteki T, Yajima N, Kawahara K, Natsui M, Kawarasaki S, Hamada K, Horie Y, Kubo Y, Arase S, Taniguchi M, Vanhaesebroeck B, Mak TW, Nakano N, Koyasu S, Sasaki T, Suzuki A
  • Journal Title: BLOOD Vol.109(8) Pages: 3316-24
  • Peer Reviewed
• [Journal Article] Role of Pten/PI3K pathway in endothelial cells (2007)
  • Author(s): Suzuki A, Hamada K, Sasaki T, Mak TW, Nakano T
  • Journal Title: Biochemical Society Transaction Vol.35(Pt2) Pages: 172-6
  • Peer Reviewed
• [Journal Article] Control of Cell Polarity and motility byPI(3, 4, 5)P3 phosphatase (2007)
  • Author(s): Nishio M, Watanabe K, Sasaki J, Taya C, Takasuga S, Iizuka R, Bella T, Yamazaki M, Watanabe H, Kuroda S, Itoh R, Forster I, Mak TW, Kanaho Y, Yonehara H, Penninger JM, Suzuki A(equal last author), Sasaki T.
  • Journal Title: SHIP NATURE CELL BIOLOGY Vol.9(1) Pages: 36-44
  • Peer Reviewed
• [Journal Article] Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas (2007)
  • Author(s): Yanagi, et. al.
  • Journal Title: J. Clin. Invest. 117 Pages: 2929-2940
  • Peer Reviewed
• [Journal Article] Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. (2007)
  • Author(s): Plum, et. al.
  • Journal Title: Cell Metab. 6 Pages: 431-445
  • Peer Reviewed
• [Journal Article] Disruption of the mouse protein Ser/Thr phosphatase 2Cβ gene leads to early pre-implantation lethality. (2007)
  • Author(s): Sasaki, et. al.
  • Journal Title: Mech. Dev. 124 Pages: 489-499
  • Peer Reviewed
• [Journal Article] Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homlolg (PTEN)-deficient mice. (2007)
  • Author(s): Watanabe, et. al.
  • Journal Title: J Gastroenterol Hepatol. Suppl1
  • Peer Reviewed
• [Journal Article] Role of Pten/PI3K pathway in endothelial cells (2007)
  • Author(s): Suzuki et al.
  • Journal Title: Biochemical Society Transaction (in press)
• [Journal Article] The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells (2007)
  • Author(s): Kishimoto et al.
  • Journal Title: Blood (in press)
• [Journal Article] Control of Cell Polarity and motility by PI(3,4,5)P3 phosphatase SHIP (2007)
  • Author(s): Nishio et al.
  • Journal Title: Nature Cell Biology 9(1) Pages: 36-44
• [Journal Article] Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients (2006)
  • Author(s): Tsuruta H, Kishimoto H, Sasaki T, Horie Y, Natsui M, Shibata Y, Hamada K, Yajima N, Kawahara K, Sasaki M, Tsuchiya N, Enomoto K, Mak TW, Nakano T, Habuchi T, Suzuki A
  • Journal Title: CANCER RESEARCH Vol.66(17) Pages: 8389-96
  • Peer Reviewed
• [Journal Article] Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN (2006)
  • Author(s): Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, McCaig CD, Penninger JM
  • Journal Title: NATURE Vol.442(7101) Pages: 457-60
  • Peer Reviewed
• [Journal Article] Enhanced PIP3 Signaling in POMC Neurons Causes Neuronal Silencing via KATP Channel Activation and Leads to Diet-sensitive Obesity (2006)
  • Author(s): Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Munzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Bruning JC
  • Journal Title: JOURNAL OF CLINICAL INVESTIGATION Vol.116(7) Pages: 1886-901
  • Peer Reviewed
• [Journal Article] Essential role of Pten in body size determination and pancreatic beta cell homeostasis in vivo (2006)
  • Author(s): Nguyen KT, Tajmir P, Lin CH, Liadis N, Zhu XD, Eweida M, Tolasa-Karaman G, Cai F, Wang R, Kitamura T, Belsham DD, Wheeler MB, Suzuki A, Mak TW, Woo M
  • Journal Title: MOLECULAR AND CELLULAR BIOLOGY Vol.26(12) Pages: 4511-8
  • Peer Reviewed
• [Journal Article] Hepatocic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge (2006)
  • Author(s): Sato W, Horie Y, Kataoka E, Ohshima S, Dohmen T, Iizuka M, Sasaki J, Sasaki T, Hamada K, Kishimoto H, Suzuki A, Watanabe S
  • Journal Title: HEPATOLOGY RESEARCH Vol.34(4) Pages: 256-65
  • Peer Reviewed
• [Journal Article] Neonatal estrogen exposure suppress PTEN-related endometrial carcinogenesis in recombinant mice (2006)
  • Author(s): Begum M, Tashiro H, Katabuchi H, Suzuki A, Kurman RJ, Okamura H
  • Journal Title: LABORATORY INVESTIGATION Vol.86(3) Pages: 286-296
  • Peer Reviewed
• [Journal Article] Hyperplasia and carcinomas in Pten- deficient mice and reduced PTEN protein in human bladder cancer patients (2006)
  • Author(s): Tsuruta et al.
  • Journal Title: Cancer Research 66(17) Pages: 8389-8390
• [Journal Article] Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN (2006)
  • Author(s): Zhao et al.
  • Journal Title: Nature 442(7101) Pages: 457-460
• [Journal Article] Essential role of Pten in body size determination and pancreatic beta cell homeostasis in vivo (2006)
  • Author(s): Nguyen et al.
  • Journal Title: Molecular and Cellular Biology 26(12) Pages: 4511-4518
• [Journal Article] Hepatocic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge (2006)
  • Author(s): Sato et al.
  • Journal Title: Hepatology Research 34(4) Pages: 256-265
• [Journal Article] 血液細胞におけるPTENの役割 (2006)
  • Author(s): 佐々木雅人ら
  • Journal Title: 血液・腫瘍科 (in press)
• [Journal Article] 脂質結合モジユールによるイノシトールリン脂質動態解析 (2006)
  • Author(s): 佐々木雄彦ら
  • Journal Title: 形と運動を司る細胞のダイナミクス(実験医学増刊号) 24(13)
• [Journal Article] 血管形成・腫瘍血管新生におけるPTEN/PI3K経路の役割 (2006)
  • Author(s): 濱田浩一ら
  • Journal Title: 実験医学増刊号 急速進展する血管研究 24(18)
• [Journal Article] Neonatal estrogen exposure suppress PTEN-related endometrial carcinogenesis in recombinant mice (2006)
  • Author(s): Begum M et al.
  • Journal Title: LABORATORY INVESTIGATION 86(3) Pages: 286-296
• [Journal Article] 生活習慣と肝臓病:診断と治療の進歩〜非アルコール性脂肪肝炎〜NASHの病態解明(実験モデルからのレッスン) (2006)
  • Author(s): 堀江泰夫ら
  • Journal Title: 日本内科学雑誌 95(1) Pages: 57-65
• [Journal Article] The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis (2005)
  • Author(s): Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Hasegawa G, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A
  • Journal Title: GENES AND DEVELOPMENT Vol.19(17) Pages: 2054-2065
  • Peer Reviewed
• [Journal Article] Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I alpha (2005)
  • Author(s): Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T, Miyazaki H, Watanabe H, Iizuka R, Kubo S, Murata S, Chiba T, Maehama T, Hamada K, Kishimoto H, Frohman MA, Tanaka K, Penninger JM, Yonekawa H, Suzuki A, Kanaho Y
  • Journal Title: JOURNAL OF EXPERIMENTAL MEDICINE Vol.201(6) Pages: 859-870
  • Peer Reviewed
• [Journal Article] Muscle-specific Pten deletion protects against insulin resistance and diabetes (2005)
  • Author(s): Wijesekara N, Konrad D, Edeida M, Jefferies C, Liadis N, Giacca A, Crockower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M
  • Journal Title: MOLECULAR AND CELLULAR BIOLOGY Vol.25(3) Pages: 1135-1145
  • Peer Reviewed
• [Journal Article] Hepatocyte-specific Pten deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellolar carcinoma (2005)
  • Author(s): Watanabe S, Horie Y, Suzuki a
  • Journal Title: HEPATPLOGY RESEACH Vol.33 Pages: 161-166
  • Peer Reviewed
• [Journal Article] The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis (2005)
  • Author(s): Hamada K et al.
  • Journal Title: GENES AND DEVELOPMENT 19(17) Pages: 2054-2065
• [Journal Article] Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I alpha. (2005)
  • Author(s): Sasaki J et al.
  • Journal Title: JOURNAL OF EXPERIMENTAL MEDICINE 201(6) Pages: 859-870
• [Journal Article] Muscle-specific Pten deletion protects against insulin resistance and diabetes. (2005)
  • Author(s): Wijesekara N et al.
  • Journal Title: MOLECULAR AND CELLULAR BIOLOGY 25(3) Pages: 1135-1145
• [Journal Article] ホスファチジルイノシトール4,5-二リン酸のコンパートメント化 (2005)
  • Author(s): 佐々木雄彦ら
  • Journal Title: 細胞工学 24(6) Pages: 607-611
• [Journal Article] 非アルコール性脂肪性肝炎(NASH)とPTEN遺伝子 (2005)
  • Author(s): 佐藤亘ら
  • Journal Title: 日本臨床 63(8) Pages: 1475-1483
• [Journal Article] 非アルコール性脂肪性肝炎-脂肪肝を発症する遺伝子変異マウスを用いた機序の解析- (2005)
  • Author(s): 渡邊純夫ら
  • Journal Title: 最新医学 60(4) Pages: 54-66
• [Journal Article] 非アルコール性脂肪性肝炎モデル動物としての肝細胞特異的PTEN欠損マウス (2005)
  • Author(s): 片岡 英ら
  • Journal Title: BIO Clinica 20(13) Pages: 1213-1217
• [Journal Article] 生活習慣病と非アルコール性脂肪性肝炎(NASH)〜肝の脂肪化と発癌〜 (2005)
  • Author(s): 渡辺純夫ら
  • Journal Title: Progress in Medicine 25(6) Pages: 1651-1656
• [Journal Article] PTEN欠損マウスによる疾患モデルマウス (2005)
  • Author(s): 河原崎哲ら
  • Journal Title: 分子細胞治療 4(2) Pages: 151-156
• [Journal Article] 脂肪肝から肝がんへ・・・NASHの新展開 (2005)
  • Author(s): 堀江泰夫ら
  • Journal Title: 日本内科学雑誌 94(5) Pages: 990-998
• [Journal Article] NAFLDの成因・NASH病変を呈する遺伝子改変マススにおける肝発癌機構 (2005)
  • Author(s): 堀江泰夫
  • Journal Title: 細胞工学 37(9) Pages: 352-356
• [Journal Article] 細胞遊走ホスホイノシタイド動態の遺伝子学的解析 (2005)
  • Author(s): 佐々木雄彦ら
  • Journal Title: 脂質生化学研究 47 Pages: 39-42
• [Presentation] PTEN結合分子PICT1の機能解析 (2009)
  • Author(s): 西尾美希、河原康一、佐々木雅人、前濱朝彦、佐々木雄彦、鈴木聡
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] 癌抑制遺伝子Matsの役割 (2009)
  • Author(s): 濱田浩一, ら
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] PTEN結合分子PICT1の細胞分化における機能解析 (2009)
  • Author(s): 西尾美希, ら
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] Novel role for PTEN in the development of the inner ear (2009)
  • Author(s): 董有毅, ら
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] PI(3,5)P_2が制御する生命現象 (2009)
  • Author(s): 佐々木雄彦, ら
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] PTEN結合分子PICT1の機能解析 (2009)
  • Author(s): 河原康一、佐々木雅人、西尾美希、濱田浩一、前濱朝彦、佐々木雄彦、鈴木聡
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-03
• [Presentation] PTEN結合分子PICT1の機能解析 (2009)
  • Author(s): 河原康一, ら
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] Function of Pten/PI3K/Akt Pathway in Bronchioalveolar Epithelium in the Pathogenesis of Lung Fibrosis (2009)
  • Author(s): Tsubouchi H, ら
  • Organizer: Eurropean respiratory Society
  • Place of Presentation: Vienna
  • Year and Date: 2009-09-16
• [Presentation] Functions of the tumor suppressor gene PTEN and its binding protein PICT1 (2009)
  • Author(s): Akira Suzuki
  • Organizer: International COE Symposium : Signal Transduction in the regulatory system and its disorders
  • Place of Presentation: Akita
  • Year and Date: 2009-06-25
• [Presentation] Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas (2008)
  • Author(s): Shigehisa Yanagi, Masamitsu Nakazato, Akira Suzuki
  • Organizer: 第13回日韓がんワークショップ
  • Place of Presentation: 韓国・大田
  • Year and Date: 2008-12-13
• [Presentation] Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas (2008)
  • Author(s): Yanagi, ら
  • Organizer: 第13回日韓がん国際ワークショップ
  • Place of Presentation: 韓国太田
  • Year and Date: 2008-12-13
• [Presentation] pi3k/aktシグナルによる多能性幹細胞システムの制御 (2008)
  • Author(s): 木村透、中村肇伸、山野範子、山本敏之、鈴木聡、仲野徹
  • Organizer: bmb学術集会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-12
• [Presentation] PI3K/Aktシグナルによる多能性幹細胞システムの制御(シンポジウム) (2008)
  • Author(s): 木村, ら
  • Organizer: BMB学術集会2008, シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] スファチジルイノシトール3リン酸5-キナーゼの生理機能解析 (2008)
  • Author(s): 高須賀, ら
  • Organizer: BMB学術集会2008
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis (2008)
  • Author(s): Inoue-Narita, ら
  • Organizer: 第8回国際ホスファターゼシンポジウム
  • Place of Presentation: 前橋
  • Year and Date: 2008-11-12
• [Presentation] Analysis of Pten Function in Bronchioalveolar Epithelium (2008)
  • Author(s): Yanagi, ら
  • Organizer: 第8回国際ホスファターゼシンポジウム
  • Place of Presentation: 前橋
  • Year and Date: 2008-11-12
• [Presentation] 神経細胞におけるL-PIPaseの機能(シンポジウム) (2008)
  • Author(s): 佐々木, ら
  • Organizer: BMB学術集会2008, シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-12
• [Presentation] PTEN欠損による肺腺がんとメラノーマのマウスモデルの樹立ーPTENと組織幹細胞 (2008)
  • Author(s): 鈴木聡、柳重久、中里雅光、井上多恵、真鍋求、濱田浩一、河原康一、佐々木雅人、西尾美希、仲野徹、佐々木雄彦
  • Organizer: 第67回日本癌学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-29
• [Presentation] PTEN欠損による肺腺がんとメラノーマのマウスモデルの樹立一PTENと組織幹細胞(シンポジウム) (2008)
  • Author(s): 鈴木, ら
  • Organizer: 第67回日本癌学会学術集会, シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Functions of PTEN in various tissues Pohang Conference on Cellular (2008)
  • Author(s): Akira Suzuki
  • Organizer: Signaling -Phospholipid-mediated signaling ligands and diseases-
  • Place of Presentation: POSTECH Biotech Center
• [Presentation] Functions of PTEN in various tissues (2008)
  • Author(s): Suzuki, A, et. al.
  • Organizer: Pohang Conference on Cellular Signaling-Phospholipid-mediated signaling-Ligands&diseases
  • Place of Presentation: Pohang, Korea
• [Presentation] PTENによる組織幹細胞制御 (2007)
  • Author(s): 鈴木聡井上多恵、柳重久、河原浩一、佐々木雅人、西尾美希、夏井美幸、真鍋求、中里雅光、仲野徹、佐々木雄彦
  • Organizer: BMB2007
  • Place of Presentation: 横浜
• [Presentation] PTEN/PI3K経路によるValpha14iNKT細胞の制御 (2007)
  • Author(s): 鈴木聡、岸本恕征、樗木俊聡、矢島伸之、河原康一、夏井美幸、谷口克、仲野徹、小安重夫、佐々木雄彦
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
• [Presentation] 気管支肺胞上皮におけるPTENの機能解析 (2007)
  • Author(s): 柳重久、中里雅光、鈴木聡
  • Organizer: 第47回日本呼吸器学会学術総会
  • Place of Presentation: 東京
• [Presentation] PTEN function in bronchioalveolar epithelium American Thoracic Society International Conference (2007)
  • Author(s): Yanagi S., Nakazato M., Suzuki A
  • Organizer: Mini-symposium
  • Place of Presentation: San Francisco
• [Presentation] PTEN function in bronchioalveolar epithelium (2007)
  • Author(s): Yanagi, S, et. al.
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: San Francisco
• [Presentation] Sex differences in hepatocyte-specific Pten-deficient mice showing steatohepatitis without ethanol challenge (2007)
  • Author(s): Anezaki, et. al.
  • Organizer: 42nd Annual Meeting of the European Associati on for the Study of the Liver
  • Place of Presentation: Barcelona
• [Presentation] Eicosapentaenoic acid improves steatohepatitis in newly established mice model of nonalcoholic steatohepatitis (2007)
  • Author(s): Ishii, et. al.
  • Organizer: 42nd Annual Meeting of the European Associati on for the Study of the Liver
  • Place of Presentation: Barcelona
• [Presentation] N-acetyl-cystein blocks progression of NASH by reducing reactive oxygen species. An examination using hepatocyte-specific Pten deficient mice (2007)
  • Author(s): Ohshima, et. al.
  • Organizer: 42nd Annual Meeting of the European Associati on for the Study of the Liver
  • Place of Presentation: Barcelona
• [Presentation] PTENによる組織幹細胞制御 (2007)
  • Author(s): 鈴木, ら
  • Organizer: BMB2007(第80回日本生化学会・第30回日本分子生物学会合同総会)ワークショップ
  • Place of Presentation: 横浜
• [Presentation] ボスホイノシチドホスファターゼの生理機能 (2007)
  • Author(s): 佐々木, ら
  • Organizer: BMB2007(第80回日本生化学会・第30回日本分子生物学会合同総会)ワークショップ
  • Place of Presentation: 横浜
• [Presentation] Functions of tumor suppressor gene PTEN in various tissues (2007)
  • Author(s): Suzuki, et. al.
  • Organizer: 第66回日本癌学会総会シンポジウム
  • Place of Presentation: 横浜
• [Presentation] 細気管支肺胞上皮におけるPTENの機能解析 (2007)
  • Author(s): 柳, ら
  • Organizer: 第47回日本呼吸器学会学術総会
  • Place of Presentation: 東京
• [Presentation] 細気管支肺胞上皮におけるPTENの機能解析 (2007)
  • Author(s): 柳, ら
  • Organizer: 第10回日本臨床分子医学会学術総会
  • Place of Presentation: 和歌山
• [Presentation] PTEN/PI3K経路によるValpha14iNKT細胞の制御 (2007)
  • Author(s): 鈴木, ら
  • Organizer: 第69回日本血液学会, 臨床血液学会総会
  • Place of Presentation: 横浜
• [Presentation] Function of PTEN in endothelial cells and NKT cells (2006)
  • Author(s): Suzuki A, Hamada K, Kishimoto H, Vanhaesbroeck B, Sasaki T
  • Organizer: 3rd Focused Meeting on PI3K Signalling and Diseases, Biochemical Society Focused Meeting
  • Place of Presentation: Bath Spa UK
• [Presentation] Role of phosphoinositide phosphatase in neutrophil migration 3rd Focused Meeting on PI3K Signalling and Diseases (2006)
  • Author(s): Sasaki T, Nishio M, Watanabe K, Takasuga S, Sasaki J, Suzuki A
  • Organizer: Biochemical Society Focused Meeting
  • Place of Presentation: Bath Spa UK
• [Presentation] PICT-1によるPTEN制御機構とその生理機能の解析 (2006)
  • Author(s): 佐々木雅人, 濱田浩一, 河原浩一, 佐々木雄彦, 前濱朝彦, 鈴木聡
  • Organizer: 第66回日本癌学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 肺胞細気管支上皮におけるPTENの機能解析 (2006)
  • Author(s): 柳重久, 岸本恕征, 河原浩一, 佐々木雄彦, 仲野徹, 中里雅光, 鈴木聡
  • Organizer: 第66回日本癌学会学術集会
  • Place of Presentation: 横浜
• [Presentation] PICT-1 is involved in early embryogenesis. Role of PTEN/PI3K pathway in T cells (2006)
  • Author(s): Sasaki M, Hamada K, Kawahara K, Sasaki T, Maehama T, Suzuki A
  • Organizer: The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: 京都
• [Presentation] Functional analysis of a tumor suppressor gene PTEN in the urothelial carcinogenesis using a conditional PTEN-deficient mouse model (2006)
  • Author(s): Tsuruta H, Kishimoto H, Sasaki T, Shibata Y, Hamada K, Tsuchiya N, Nakano T, Habuchi T, Suzuki A
  • Organizer: 米国泌尿器科学会
  • Place of Presentation: ATLANTA
• [Presentation] 膀胱・尿路上皮におけるPTENの機能解析 (2006)
  • Author(s): 鶴田大, 岸本恕征, 佐々木雄彦, 濱田浩一, 仲野徹, 羽渕友則, 鈴木聡
  • Organizer: 第94回日本泌尿器科学会総会
  • Place of Presentation: 福岡
• [Presentation] (2005)
  • Author(s): 黒田聖子, 岸本恕征, 佐々木雄彦, 仲野徹, 鈴木聡
  • Organizer: 日本免疫学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Mechanism of steatohepatitis in hepatocyte-specific Pten deficient mice, an animal model of nonalcoholic steatohepatitis (2005)
  • Author(s): Horie Y, Kataoka E, Ohshima S, Sato W, Dohmen T, Goto T, Takeuchi S, Iizuka M, Suzuki A, Watanabe S
  • Organizer: 第56回アメリカ肝臓病学会(AASLD:American Association for the Study of Liver Disease)
  • Place of Presentation: サンフランシスコ
• [Presentation] メラノサイトにおけるptenの機能解析 (2005)
  • Author(s): 井上多恵, 濱田浩一, 岸本恕征, 佐々木雄彦, 仲野徹, 真鍋求, 鈴木聡
  • Organizer: 第64回日本癌学会学術集会
  • Place of Presentation: 札幌
• [Presentation] 膀胱・尿路上皮におけるPTENの機能解析 (2005)
  • Author(s): 鶴田大, 岸本恕征, 佐々木雄彦, 濱田浩一, 仲野徹, 羽淵友則, 鈴木聡
  • Organizer: 第64回日本癌学会学術集会
  • Place of Presentation: 札幌
• [Presentation] 発がん研究と動物モデル脂質メディエーターPTEN/pi3K経路異常による発癌と疾患 (2005)
  • Author(s): 鈴木聡, 佐々木雄彦, 濱田浩一, 岸本恕征, 佐々木雅人, 鶴田大, 羽淵友則, 井上多恵, 真鍋求, 仲野徹
  • Organizer: 第64回日本癌学会学術集会
  • Place of Presentation: 札幌
• [Presentation] Mechanism for the onset of steatohepatitis in hepatocyte-specific Pten deficient mice, an animal model of nonalcoholic steatohepatitis(NASH) (2005)
  • Author(s): Watanabe S, Horie Y, Kataoka E, Ohshima S, Sato W, Dohmen T, Goto T, Takeuchi S, Suzuki A
  • Organizer: World Congress of Gastroenterology
  • Place of Presentation: Montreal
• [Book] 造血器腫瘍アトラス (2009)
  • Author(s): 阿部達生, ら
  • Total Pages: 594
  • Publisher: 日本医事新報社
• [Book] 分子細胞生物学辞典(第二版) (2008)
  • Author(s): 鈴木聡
  • Total Pages: 1
  • Publisher: PTEN
• [Book] 医学のあゆみ (2007)
  • Author(s): 河原, ら
  • Publisher: PTEN/PI3K経路による血管制御
• [Book] 遺伝子医学MOOK(がん抑制遺伝子PTEN, 6) (2006)
  • Author(s): 柳重久、中里雅光、鈴木聡
• [Book] 発がんの分子機構と防御(発がんモデルマウスとがん関連遺伝子の機能解析) (2006)
  • Author(s): 鈴木聡、柳沼克幸、野田哲生
  • Publisher: 東大出版会
• [Book] 造血器腫瘍アトラス (2006)
  • Author(s): 矢島伸之ら
  • Publisher: 日本医事新報社(In press)
• [Book] 遺伝子医学MOOK6号 (2006)
  • Author(s): 柳重久ら
  • Publisher: メディカルドゥ(In press)
• [Book] 発がんの分子機構と防御 (2006)
  • Author(s): 鈴木聡ら
  • Publisher: 東京大学出版会
• [Book] 発がんの分子機構と防御 (2006)
  • Author(s): 鈴木 聡ら
  • Total Pages: 197
  • Publisher: 東大出版会
• [Book] 再生医療のための分子生物学 (2006)
  • Author(s): 佐々木雄彦ら
  • Total Pages: 250
• [Remarks]
  • URL: http://www.bioreg.kyushu-u.ac.jp/hassei/Home.html