| Budget Amount *help |
¥47,000,000 (Direct Cost: ¥47,000,000)
Fiscal Year 2009: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2008: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2007: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2006: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2005: ¥9,400,000 (Direct Cost: ¥9,400,000)
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| Research Abstract |
To elucidate in vivo function of Maf oncogenes for tumorigenesis, I tried to generate transgenic mice which overexpressed c-Maf in lymphoid cells. By analyzing these mice, I identified the development of lymphomas. ARK5, Cyclin D2 and Integrinβ7 were confirmed as target genes of c-Maf in the tumor cells. In addition, I analyzed patients with T cell lymphomas and found that c-Maf was overexpressed in Anigioimmunoblastic T cell lumphoma (AILT) cells in collaboration. These results indicate that c-Maf is the responsible gene for tumorigenesis of lymphocytes.
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