Roles of transcription factors for carcinogenesis and carcinogenesisdefense

• Project/Area Number: 17013017
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University (2007-2009); University of Tsukuba (2005-2006)
• Principal Investigator: MASAYUKI Yamamoto Tohoku University, 大学院・医学系研究科, 教授 (50166823)
• Co-Investigator(Kenkyū-buntansha): RITSUKO Shimizu 東北大学, 大学院・医学系研究科, 教授 (40226262) ; KINUKO Ohneda 高崎健康福祉大学, 薬学部・薬学科, 教授 (50323291)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥124,000,000 (Direct Cost: ¥124,000,000); Fiscal Year 2009: ¥24,800,000 (Direct Cost: ¥24,800,000); Fiscal Year 2008: ¥24,800,000 (Direct Cost: ¥24,800,000); Fiscal Year 2007: ¥24,800,000 (Direct Cost: ¥24,800,000); Fiscal Year 2006: ¥24,800,000 (Direct Cost: ¥24,800,000); Fiscal Year 2005: ¥24,800,000 (Direct Cost: ¥24,800,000)
• Keywords: 転写因子 / 発癌 / 癌抑制 / 多段階発がん / GATA1 / 白血病幹細胞 / 幹細胞性 / 治療抵抗性 / 巨核芽球白血病 / ダウン症候群 / 一過性骨髄増殖症 / 前赤芽球性性白血病 / 質的異常 / 量的異常 / GATA-1 / GATA-2 / Nrf2 / Keap1造血 / 白血病 / 酸化ストレス / 遺伝子改変マウス

Research Abstract

In this study, we investigated roles transcription factors play on carcinogenesis and carcinogenesis defense in vivo, focusing on the Nrf2 and GATA transcription factors. We have found that co-operative function of Nrf2 and Keap1, which mediates cellular stress response, is important for the cancer carcinogenesis defense so that the failure in Nrf2-Keap1 system leads to the onset of cancer and poor prognosis. We have further found that deregulated function of GATA factors, which act as key molecules in hematopoietic homeostasis, causes leukemogenesis.

Research Products

• [Journal Article] Novel regulation of the Nrf2-Keap1 pathway by the selective autophagy substrate p62 (2010)
  • Author(s): Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou Y-S, Ueno I, Sakamoto A, Tong KI, Kim M, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M
  • Journal Title: Nature Cell Biol 12 Pages: 213-223
  • Peer Reviewed
• [Journal Article] Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis (2010)
  • Author(s): Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M
  • Journal Title: Mol Cell Biol 12 Pages: 3016-3026
• [Journal Article] Genetic analysis of cytoprotective functions supported by graded expression of Keap1 (2010)
  • Author(s): Taguchi K, Maher JM, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M
  • Journal Title: Mol Cell Biol
• [Journal Article] Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domain (2010)
  • Author(s): Kobayashi E, Shimizu R, Kikuchi Y, Takahashi S, Yamamoto M
  • Journal Title: J Biol Chem 285 Pages: 773-783
• [Journal Article] NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation (2010)
  • Author(s): Motohashi H, Kimura M, Fujita R, Takayama M, Pan XQ, Katsuoka F, Aburatani H, Bresnick EH, Yamamoto M
  • Journal Title: Blood 115 Pages: 677-686
• [Journal Article] Keap1 homodimer is a forked-stem structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains (2010)
  • Author(s): Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, Yamamoto M
  • Journal Title: Proc Natl Acad Sci USA 107 Pages: 2842-2847
• [Journal Article] Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucurono syltransferases during BBN-induced urinary bladder carcinogenesis in mice (2010)
  • Author(s): Iida K, Itoh K, Mimura J, Ohyama C, Fujii-Kuriyama Y, Shimazui T, Akaza H, Yamamoto M
  • Journal Title: J Biochem 147 Pages: 353-360
  • NAID: 10027874393
  • Peer Reviewed
• [Journal Article] Novel regulation of the Nrf2-Keap1 pathway by the selective autophagy substrate p62 (2010)
  • Author(s): Komatsu M, Kurokawa H, Waqun S, Iaguchi K, Kobayashi A, Ichimura Y, Sou Y-S, Ueno I, Sakamoto A, Tong KI, Kim M, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M
  • Journal Title: Nature Cell Biol 12 Pages: 213-223
  • Peer Reviewed
• [Journal Article] The transcriptome of Nrf2^<-/-> Mice provides evidence for impaired cell cycle progress ion in the development of cigarette-smoke-induced emphysematous changes (2010)
  • Author(s): Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schuller J, Xu H, Taguchi K, Yamamoto M, Muller T
  • Journal Title: Tox Sci (印刷中)
  • Peer Reviewed
• [Journal Article] The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds (2009)
  • Author(s): Kobayashi M, Li L, Iwamoto N, Nakajima- Takagi Y, Kaneko H, Nakayama Y, Eguchi M, Wada Y, Kumagai Y, Yamamoto M
  • Journal Title: Mol Cell Biol 29 Pages: 493-502
  • NAID: 120007138388
• [Journal Article] Stem cells of GATA1-related leukemia undergo pernicious changes after 5-fluorouracil treatment (2009)
  • Author(s): Abe K, Shimizu R, Pan X, Hamada H, Yoshikawa H, Yamamoto M
  • Journal Title: Exp Hematol 37 Pages: 435-445
• [Journal Article] Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis (2009)
  • Author(s): Kadri Z, Shimizu R, Ohneda O, Maouche-Chretien L, Gisselbrecht S, Yamamoto M, Romeo PH, Leboulch P, Chretien S
  • Journal Title: PLoS Biol 7
• [Journal Article] Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant (2009)
  • Author(s): Shimizu R, Kobayashi E, Engel JD, Yamamoto M
  • Journal Title: Genes Cells 14 Pages: 1119-1131
• [Journal Article] Structural basis of alternative DNA recognition by Maf transcription factors (2009)
  • Author(s): Kurokawa H, Motohashi H, Sueno S, Kimura M, Takagawa H, Kanno Y, Yamamoto M, Tanaka T
  • Journal Title: Mol Cell Biol 29 Pages: 6232-6244
• [Journal Article] The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds (2009)
  • Author(s): Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, Nakayama Y, Eguchi M, Wada Y, Kumagai Y, Yamamoto M
  • Journal Title: Mol Cell Biol 29 Pages: 493-502
  • NAID: 120007138388
  • Peer Reviewed
• [Journal Article] Differential contribution of the Gata1 gene hematopoietic enhancer to erythroid differentiation (2009)
  • Author(s): Suzuki M, Moriguchi T, Ohneda K, Yamamoto M
  • Journal Title: Mol Cell Biol 29 Pages: 1163-1175
  • Peer Reviewed
• [Journal Article] Increased Nrf2 activation in Keap1-knockdown mice increases hepatic cytoprotective genes that detoxify electrophiles but not reactive oxygen species (2009)
  • Author(s): Reisman SA, Yeager RL, Yamamoto M, Klaassen CD
  • Journal Title: Tox Sci 108 Pages: 35-47
  • Peer Reviewed
• [Journal Article] Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents (2009)
  • Author(s): Higgins LG, Kelleher MO, Eggleston IM, Itoh K, Yamamoto M, Hayes JD
  • Journal Title: Toxicol Appl Pharmacol 237 Pages: 267-280
  • Peer Reviewed
• [Journal Article] Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice (2009)
  • Author(s): Prince M, Li Y, Childers A, Itoh K, Yamamoto M, Kleiner HE
  • Journal Title: Toxicol Lett 185 Pages: 180-186
  • Peer Reviewed
• [Journal Article] Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans (2009)
  • Author(s): Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M
  • Journal Title: Cancer Prev Res 2 Pages: 353-360
  • Peer Reviewed
• [Journal Article] Genetic versus chemoprotective activation of Nrf2 signaling : overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid treated mice (2009)
  • Author(s): Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW
  • Journal Title: Carcinogenesis 30 Pages: 1024-1031
  • Peer Reviewed
• [Journal Article] Nrf2 enhances cell proliferation and resistance to anticancer drugs in hum an lung cancer (2009)
  • Author(s): Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, Kikuchi N, Satoh H, Sakamoto T, Hizawa N, Itoh K, Yamamoto M
  • Journal Title: Clin Cancer Res 15 Pages: 3423-3432
  • Peer Reviewed
• [Journal Article] 1-Cyano-2, 3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic{alpha},{beta}-unsaturated aldehyde acrolein (2009)
  • Author(s): Kelleher MO, McMahon M, Eggleston IM, Dixon MJ, Taguchi K, Yamamoto M, Hayes JD
  • Journal Title: Carcinogenesis 30 Pages: 1754-1762
  • Peer Reviewed
• [Journal Article] Targeting Nrf2 with the Triterpenoid CDDO-Imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice (2009)
  • Author(s): Sussan IE, Hangasamy T, Blake DJ, Mainotra U, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 250-255
  • Peer Reviewed
• [Journal Article] Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems (2009)
  • Author(s): Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Sugimoto H, Utsunomiya H, Oda K, Warabi E, Ishii T, Yamamoto M
  • Journal Title: Biochem Biophys Res Commun 389 Pages: 431-436
  • Peer Reviewed
• [Journal Article] Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs (2009)
  • Author(s): Singh A, Ling G, Suhasini AN, Z hang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S
  • Journal Title: Free Radic Biol Med 46 Pages: 376-386
  • Peer Reviewed
• [Journal Article] Stem cells of GATA1-related leukemia undergo pernicious changes after 5-fluorouracil treatment (2009)
  • Author(s): Abe K, Shimizu R, Pan X, Hamada H, Yoshikawa H, and Yamamoto M
  • Journal Title: Exp Hematol 37 Pages: 435-445
  • Peer Reviewed
• [Journal Article] Increased Nrf2 activation in Keapl-knockdown mice increases hepatic cyto protective genes that detoxify electrophiles but not reactive oxygen species (2009)
  • Author(s): Reisman SA, Yeager RL, Yamamoto M, and Klaassen CD
  • Journal Title: Tox Sci 108 Pages: 35-47
  • Peer Reviewed
• [Journal Article] Leukemia-related transcription factor TEL/ETV6 expands erythroid precursors and stimulates hemoglobin synthesis. (2009)
  • Author(s): Eguchi-lshimae M, Eguchi M, Maki K, Porcher C, Shimizu R, Yamamoto M, and Mitani K
  • Journal Title: Cancer Sci 100 Pages: 689-697
  • NAID: 10025144516
  • Peer Reviewed
• [Journal Article] Deletion of the selenocysteine tRNA gene in macrophage and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2 (2008)
  • Author(s): Suzuki T, Kelly VP, Motohashi H, Nakajima O, Takahashi S, Nishimura S, Yamamoto M
  • Journal Title: J Biol Chem 283 Pages: 2021-2030
• [Journal Article] Molecular evolution of Keap1: Two Keap1 molecules with distinctive IVR structures are conserved among fish (2008)
  • Author(s): Li L, Kobayashi M, Kaneko H, Nakajima-Takagi Y, Nakayama Y, Yamamoto M
  • Journal Title: J Biol Chem 283 Pages: 3248-3255
• [Journal Article] Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity (2008)
  • Author(s): Yamamoto T, Suzuki T, Kobayashi A, Wakabayashi J, Maher J, Motohashi H, Yamamoto M
  • Journal Title: Mol Cell Biol 28 Pages: 2758-2770
• [Journal Article] Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy (2008)
  • Author(s): Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 13568-13573
• [Journal Article] NRF1 and NRF2 play distinct roles in activation of antioxidant response element-dependent genes (2008)
  • Author(s): Ohtsuji M, Katsuoka F, Kobayashi A, Aburatani H, Hayes JD, Yamamoto M
  • Journal Title: J Biol Chem 283 Pages: 33554-33562
• [Journal Article] Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice (2008)
  • Author(s): Yoh K, Hirayama A, Ishizaki K, Yamada A, Takeuchi M, Yamagishi S, Morito N, Nakano T, Ojima M, Shimohata H, Itoh K, Takahashi S, Yamamoto M
  • Journal Title: Genes Cells 13 Pages: 1159-1170
• [Journal Article] GATA1-related leukaemias (2008)
  • Author(s): Shimizu R, Engel JD, Yamamoto, M.
  • Journal Title: Nature Reviews Cancer 8 Pages: 279-287
• [Journal Article] Impairment of erythroid and megakaryocytic differentiation by a leukemia-associated and t(9 ; 9)-derived fusion gene product, SET/TAF-IB-CAN/Nup214 (2008)
  • Author(s): Saito S, Nouno K, Shimizu R, Yamamoto M, and Nagata K
  • Journal Title: J Cell Physiol 214 Pages: 322-333
  • Peer Reviewed
• [Journal Article] Loss of Keap 1 function activates Nrf2 and provides advantages for lung cancer cells growth (2008)
  • Author(s): Ohta T, Iijima K, Miyamoto M, Nakahara I, Odagawa R, Mimaki S, Sakiyama T, Tanaka H, Ohtsuji M, Suzuki T, Kobayashi A, Shibata T, Yamamoto M, and Hirohashi S
  • Journal Title: Cancer Res 68 Pages: 1303-1309
  • Peer Reviewed
• [Journal Article] Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein (2008)
  • Author(s): Higgins LG, Cavin C, Itoh K, Yamamoto M, and Hayes JD
  • Journal Title: Toxicol Appl Pharmacol 226 Pages: 328-337
  • Peer Reviewed
• [Journal Article] Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice (2008)
  • Author(s): Kawachi Y, Xu X, Taguchi S, Sakurai H, Nakamura Y, Ishii Y, Fujisawa Y, Furuta J, Takahashi T, Itoh K, Yamamoto M, Yamazaki F, and Otsuka F
  • Journal Title: J Invest Dermatol 128 Pages: 1773-1779
  • Peer Reviewed
• [Journal Article] Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction (2008)
  • Author(s): Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo M V, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas P, de Cabo R
  • Journal Title: Proc Nati Acad Sci USA 105 Pages: 2325-2330
  • Peer Reviewed
• [Journal Article] Ephrin-A1 promotes the malignant progression of intestinal tumors in Apc-mice (2008)
  • Author(s): Shi L, Itoh F, Itoh S, Takahashi S, Yamamoto M, and Kato M
  • Journal Title: Oncogene 27 Pages: 3265-3273
  • Peer Reviewed
• [Journal Article] Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady state and stress erythropoiesis (2008)
  • Author(s): Gutierrez L, Tsukamoto S, Suzuki M, Yamamoto-Mukai H, Yamamoto M, Philipsen S, and Ohneda K
  • Journal Title: Blood 111 Pages: 4375-4385
  • Peer Reviewed
• [Journal Article] Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts (2008)
  • Author(s): Harada H, Sugimoto R, Watanabe A, Taketani S, Okada K, Warabi E, Siow R, Itoh K, Yamamoto M, and Ishii T
  • Journal Title: Free Radical liesearcn 42 Pages: 297-304
  • Peer Reviewed
• [Journal Article] Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells (2008)
  • Author(s): Taguchi K, Shimada M, Fujii S, Sumi D, Pan X, Yamano S, Nishiy ama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, and Kumagai Y
  • Journal Title: Free Radic Biol Med 44 Pages: 1645-1655
  • Peer Reviewed
• [Journal Article] Activation of nuclear factor E2-related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development (2008)
  • Author(s): Marhenke S, Lamle J, Buitrago-Molina LE, Canon JM, Geffers R, Finegold M, Sporn M, Yamamoto M, Manns MP, Grompe M, and Vogel A
  • Journal Title: Hepatology 48 Pages: 487-496
  • Peer Reviewed
• [Journal Article] A possible role of Nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate (2008)
  • Author(s): Kanki K, Umemura T, Kitamura Y , Ishii Y, Kuroiwa Y, Kodama Y, Itoh K, Yamamoto M, Nishikawa A. and Hirose M
  • Journal Title: Toxicol Pathol 36 Pages: 353-361
  • Peer Reviewed
• [Journal Article] Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap 1 (2008)
  • Author(s): Padmanabhan B, Tong KI, Kobay ashi A, Yamamoto M, and Yokoyama S
  • Journal Title: J Synchrotron Radiat 15(Pt3) Pages: 273-276
  • Peer Reviewed
• [Journal Article] Genetic or pharmacologic amplification of Nrf2 signaling inhibits acute intiammatory liver injury in mice (2008)
  • Author(s): Osburn WO, Yates MS, Dolan PD Liby KT, Sporn MB, Taguchi K, Yamamoto M, and Kensler T
  • Journal Title: Toxicol Sci 104 Pages: 218-227
  • Peer Reviewed
• [Journal Article] The transcription factor Nrf2 is a therapeutic target against brain intlammation (2008)
  • Author(s): Innamorato NG, Rojo Al, Garcia-Yagile kJ, Yamamoto M, de Ceballos ML. and Cuadrado A
  • Journal Title: J Immunol 181 Pages: 680-689
  • Peer Reviewed
• [Journal Article] Nuclear Factor E2-Related Factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress (2008)
  • Author(s): Zhu H, Jia Z, Misra BR, Zhang L , Cao Z, Yamamoto M, Trush M A, Misra HP, and Li Y
  • Journal Title: Cardiovasc Toxicol 8 Pages: 71-85
  • Peer Reviewed
• [Journal Article] Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice (2008)
  • Author(s): Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S. and Suaawara I
  • Journal Title: Clin Immunol 128 Pages: 366-373
  • Peer Reviewed
• [Journal Article] Activation of nuclear factor E2-related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development (2008)
  • Author(s): Marhenke S, Lamle J, Buitrago-M olina LE, Cali& JM, Geffers R, Finegold M, Sporn M, Yamamoto M, Manns MP, Grompe M, and Vogel A
  • Journal Title: Hepatology 48 Pages: 487-496
  • Peer Reviewed
• [Journal Article] Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer (2008)
  • Author(s): Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, and Hirohashi S
  • Journal Title: Gastroenterology 135 Pages: 1358-1368
  • Peer Reviewed
• [Journal Article] Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy (2008)
  • Author(s): Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, and Hirohashi S
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 13568-13573
  • Peer Reviewed
• [Journal Article] Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter (2008)
  • Author(s): Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, and Georas SN
  • Journal Title: J Immunol 181 Pages: 4545-4159
  • Peer Reviewed
• [Journal Article] Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice (2008)
  • Author(s): Yoh K, Hirayama A, Ishizaki K, Y amada A, Takeuchi M, Yamagishi S, Morito N, Nakano T, Ojima M, Shimohata H, Itoh K, Takahashi S, and Yamamoto M
  • Journal Title: Genes Cells 13 Pages: 1159-1170
  • Peer Reviewed
• [Journal Article] GATA1-related leukaemias (2008)
  • Author(s): Shimizu R, Engel JD and Yamamoto, M
  • Journal Title: Nature Reviews Cancer 8 Pages: 279-287
  • Peer Reviewed
• [Journal Article] GATA-1の機能異常と白血病-Leukemogenesis related to GATA-1 mutation- (2008)
  • Author(s): 安倍加奈子・清水律子・山本雅之
  • Journal Title: 日本産婦人科血液学会誌 17 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Nrf2-Keap1制御系から望む呼吸器疾患 (2008)
  • Author(s): 佐藤大希・山本雅之
  • Journal Title: 呼吸 27 Pages: 439-445
  • Peer Reviewed
• [Journal Article] Impairment of erythroid and megakaryocytic differentiation by a leukemia -associated and t(9; 9)-derived fusion gene product, SET/TAF-Ib-CAN/Nup 214. (2008)
  • Author(s): Saito S, Nouno K, Shimizu R, Yamamoto M, and Nagata K.
  • Journal Title: J Cell Physiol. 214 Pages: 322-333
  • Peer Reviewed
• [Journal Article] GATA-1の機能異常と白血病-Leukemogenesis related to GATA-1 mutation- (2008)
  • Author(s): 安倍加奈子、清水律子、山本雅之
  • Journal Title: 日本産婦人科血液学会誌 17 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes (2007)
  • Author(s): Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, Yamamoto M
  • Journal Title: Biochem J 404 Pages: 459-466
• [Journal Article] Enhanced spontaneous and benzo[a]pyrene- induced mutations in the lung of Nrf2-deficient gpt delta mice (2007)
  • Author(s): Aoki Y, Hashimoto AH, Amanuma K, Matsumoto M, Hiyoshi K, Takano H, Masumura K, Itoh K, Nohmi T, Yamamoto M
  • Journal Title: Cancer Res 67 Pages: 5643-5648
• [Journal Article] Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis (2007)
  • Author(s): Iida K, Itoh K, Maher JM, Kumagai Y, Oyasu R, Mori Y, Fukushima S, Shimazui T, Akaza H, Yamamoto M
  • Journal Title: Carcinogenesis 28 Pages: 2398-2403
• [Journal Article] Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response (2007)
  • Author(s): Tong KI, Padmanabhan B, Kobayashi A, Shang C, Hirotsu Y, Yokoyama S, Yamamoto M
  • Journal Title: Mol Cell Biol 27 Pages: 7511-7521
• [Journal Article] Subcellul localization and cytoplasmic complex status of endogenous Keap1 (2007)
  • Author(s): Watai Y, Kobayashi A, Nagase H, Mizukami M, McEvoy J, Singer JD, Itoh K, Yamamoto M
  • Journal Title: Genes Cells 12 Pages: 1163-1178
• [Journal Article] Potential involvement of pathophysiologically formed 8-nitorguanosine 3', 5'-cyclic monophosphate in nitric oxide-induced signal transduction (2007)
  • Author(s): Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T
  • Journal Title: Nature Chem Biol 3 Pages: 727-735
• [Journal Article] Loss of p62/SQSTM1 suppresses cytoplasmic inclusion body formation and liver injury in autophagy-deficient mouse (2007)
  • Author(s): Komatsu M, Waguri S, Koike M, Sou Y, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K
  • Journal Title: Cell 131 Pages: 1149-1163
• [Journal Article] Molecular basis distinguishing the DNA binding profile of NRF2-MAF heterodimer from that of MAF homodimer (2007)
  • Author(s): Kimura M, Yamamoto T, Zhang J, Itoh K, Kyo M, Kamiya T, Aburatani H, Katsuoka F, Kurokawa H, Tanaka T, Motohashi H, Yamamoto M
  • Journal Title: J Biol Chem 282 Pages: 33681-33690
• [Journal Article] Carcinogenesis and transcriptional regulation through Maf recognition elements (2007)
  • Author(s): Motohashi H, Yamamoto M
  • Journal Title: Cancer Sci 98 Pages: 135-139
• [Journal Article] Characterization of GATA-1^+ hemangioblastic cells in the mouse embryo. (2007)
  • Author(s): Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, and Yamamoto M.
  • Journal Title: EMBO J. 26 Pages: 184-196
  • Peer Reviewed
• [Journal Article] Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo [4, 5-f] quinoline. (2007)
  • Author(s): Kitamura Y, Umemura T, kanki K, Kodama Y, Kitamoto S, Saito K, Itoh K, Yamamoto M, Masegi T, Nishikawa A, and Hirose M.
  • Journal Title: Cancer Sci. 98 Pages: 19-24
  • Peer Reviewed
• [Journal Article] Shear stress stabilizes NF-E2 related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species. (2007)
  • Author(s): Warabi E, Takabe W, Minami T, Inoue K, Itoh K, Yamamoto M, Ishii T, Kodama T, and Noguchi N.
  • Journal Title: Free Rad Biol Med. 42 Pages: 260-269
  • Peer Reviewed
• [Journal Article] Inchinkoto, an herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in ratlivers. (2007)
  • Author(s): Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y and Suzuki H.
  • Journal Title: Am J Physiol Gastrointestinal Liver Physiol. 295 Pages: 1450-1463
  • Peer Reviewed
• [Journal Article] Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. (2007)
  • Author(s): Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, and Kensler TW.
  • Journal Title: Mol Cancer Therapeutics. 6 Pages: 154-161
  • Peer Reviewed
• [Journal Article] Does K-11706 enhance performance and why? (2007)
  • Author(s): Imagawa S, Matsumoto K, Horie M, Ohkoshi N, Nagasawa T, Doi T, Suzuki N, and Yamamoto M.
  • Journal Title: Int J Sports Med. 28 Pages: 928-933
  • Peer Reviewed
• [Journal Article] Functional polymorphisms in the transcription factor NRF2 increase the risk of acute lung injury. (2007)
  • Author(s): Marzec JM, Christie JD, Reddy SP, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Yamamoto T, Yamamoto M, Cho, H-Y, and Kleeberger SR.
  • Journal Title: FASEB J. 21 Pages: 2237-2246
  • Peer Reviewed
• [Journal Article] Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t (8;21)(q24;q22) acute myeloid leukemia. (2007)
  • Author(s): Asou N, Yanagida M, Huang L, Yamamoto M, Shigesada K, Mitsuya H, Ito Y, and Osato M.
  • Journal Title: Blood. 109 Pages: 4023-4027
  • Peer Reviewed
• [Journal Article] Cell cycle-dependent oscillation of GATA2 expression in hematopoietic cells. (2007)
  • Author(s): Koga S, Yamaguchi N, Abe T, Minegishi M, Tsuchiya S, Yamamoto M, and Minegishi N.
  • Journal Title: Blood. 109 Pages: 4200-4208
  • Peer Reviewed
• [Journal Article] Dynamic regulation of Gata factor levels is more important than their identity. (2007)
  • Author(s): Ferreira R, Wai A, Shimizu R, Gillemans N, Rottier R, von Lindem M, Ohneda K, Grosveld F, Yamamoto M, and Philipsen S.
  • Journal Title: Blood. 109 Pages: 5481-5490
  • Peer Reviewed
• [Journal Article] Nrf2 Neh5 domain is differentially utilized in the transactivation of cytop rotective genes. (2007)
  • Author(s): Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, and Yamamoto M.
  • Journal Title: Biochem J. 404 Pages: 459-466
  • Peer Reviewed
• [Journal Article] A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. (2007)
  • Author(s): Khandekar M, Brandt W, Zhou Y, Dagenais S, Glover TW, Suzuki N, Shimizu R, Yamamoto M, Lim K-C, and Engel JD.
  • Journal Title: Development. 139 Pages: 1703-1712
  • Peer Reviewed
• [Journal Article] Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. (2007)
  • Author(s): Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, . Chen YT, Chang C, Yamamoto M, Tanimoto K, Engel JD.
  • Journal Title: EMBO J. 26 Pages: 2295-2306
  • Peer Reviewed
• [Journal Article] GATA-1 self-association controls erythroid development in vivo. (2007)
  • Author(s): Shimizu R, Trainor CD, Nishikawa K, Kobayashi M, Ohneda K, and Yamamoto M.
  • Journal Title: J Biol Chem. 282 Pages: 15862-15871
  • Peer Reviewed
• [Journal Article] Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. (2007)
  • Author(s): Reddy NM, Kleeberger SR, Cho H-Y, Yamamoto M, Kensler TW, Biswal S, and Reddy SP.
  • Journal Title: Am J Res Cell Mol Biol. 37 Pages: 3-8
  • Peer Reviewed
• [Journal Article] Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. (2007)
  • Author(s): Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, and Dore S.
  • Journal Title: Neuroscience. 147 Pages: 53-59
  • Peer Reviewed
• [Journal Article] Enhanced spontaneous and benzo[α]pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice. (2007)
  • Author(s): Aoki Y, Hashimoto AH, Amanuma K, Matsumoto M, Hiyoshi K, Takano H, Masumura K, Itoh K, Nohmi T and Yamamoto M.
  • Journal Title: Cancer Res. 67 Pages: 5643-5648
  • Peer Reviewed
• [Journal Article] Oxidative and electrophilic stress induces Mrp transporters via the Nrf2 transcriptional pathway. (2007)
  • Author(s): Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, and Klaassen CD.
  • Journal Title: Hepatology. 46 Pages: 1597-1610
  • Peer Reviewed
• [Journal Article] Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. (2007)
  • Author(s): Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, and Dore S.
  • Journal Title: Free Rad Biol Med. 43 Pages: 408-414
  • Peer Reviewed
• [Journal Article] Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis. (2007)
  • Author(s): Iida K, Itoh K, Maher JM, Kumagai Y, Oyasu R, Mori Y, Fukushima S, Shimazui T, Akaza H, and Yamamoto M.
  • Journal Title: Carcinogenesis. 28 Pages: 2398-2403
  • Peer Reviewed
• [Journal Article] NRF2 modulates ary1 hydrocarbon receptor signaling: Influence on adipogenesis. (2007)
  • Author(s): Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, Yamamoto M, and Kensler TW.
  • Journal Title: Mol Cell Biol. 27 Pages: 7188-7197
  • Peer Reviewed
• [Journal Article] Different Electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. (2007)
  • Author(s): Tong KI, Padmanabhan B, Kobayashi A, Shang C, Hirotsu Y, Yokoyama S, and Yamamoto M.
  • Journal Title: Mol Cell Biol. 27 Pages: 7511-7521
  • Peer Reviewed
• [Journal Article] Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. (2007)
  • Author(s): Osburn WO, Karim B, Dolan PM, Liu G, Yamamoto M, Huso DL, and Kensler TW.
  • Journal Title: Int J Cancer. 121 Pages: 1883-1891
  • Peer Reviewed
• [Journal Article] Subcellul localization and cytoplasmic complex status of endogenous Keapl. (2007)
  • Author(s): Watai Y, Kobayashi A, Nagase H, Mizukami M, McEvoy J, Singer JD, Itoh K, and Yamamoto M.
  • Journal Title: Genes Cells. 12 Pages: 1163-1178
  • Peer Reviewed
• [Journal Article] In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression. (2007)
  • Author(s): Takeuchi Y, Yahagi N, Nakagawa Y, Matsuzaka T, Shimizu R, Sekiya M, Iizuka Y, Ohashi K, Gotoda T, Yamamoto M, Nagai R, Kadowaki T, Yamada N, Osuga JI, and Shimano H.
  • Journal Title: Biochem Biophys Res Commun. 363 Pages: 329-335
  • NAID: 120007139072
  • Peer Reviewed
• [Journal Article] Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity. (2007)
  • Author(s): Toyama T, Sumi D, Shinkai Y, Yasutake A, Taguchi K, Tong KI, Yamamoto M, and Kumagai Y.
  • Journal Title: Biochem Biophys Res Commun. 363 Pages: 645-650
  • Peer Reviewed
• [Journal Article] Potential involvement of pathophysiologically formed 8-nitroguanosine 3', 5'-cyclic monophosphate in nitric oxide-induced signal transduction. (2007)
  • Author(s): Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, and Akaike T.
  • Journal Title: Nature Chem Biol. 3 Pages: 727-735
  • Peer Reviewed
• [Journal Article] The N-terminal homology box 1 (NHB1) sequence in transcription factor Nrfl is required to anchor it to the endoplasmic reticulum and also to enable its Asn-glycosylation. (2007)
  • Author(s): Zhang Y, Lucocq JM, Yamamoto M, and Hayes JD.
  • Journal Title: Biochem J. 408 Pages: 161-172
  • Peer Reviewed
• [Journal Article] The TR2 and TR4 orphan nuclear receptors repress Gatal transcription. (2007)
  • Author(s): Tanabe O, Shen Y, Liu Q, Campbell AD, Kuroha T, Yamamoto M, and Engel JD.
  • Journal Title: Genes Dev. 21 Pages: 2832-2844
  • Peer Reviewed
• [Journal Article] Loss of p62/SQSTM1 suppresses cytoplasmic inclusion body formation and liver injury in autophagy-deficient mouse. (2007)
  • Author(s): Komatsu M, Waguri S, Koike M, Sou Y, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E and Tanaka K
  • Journal Title: Cell. 131 Pages: 1149-1163
  • Peer Reviewed
• [Journal Article] Molecular basis distinguishing the DNA binding profile of NRF2-MAF heterodimer from that of MAF homodimer. (2007)
  • Author(s): Kimura M, Yamamoto T, Zhang J, Itoh K, Kyo M, Kamiya T, Aburatani H, Katsuoka F, Kurokawa H, Tanaka T, Motohashi H, and Yamamoto M.
  • Journal Title: JBiol Chem. 282 Pages: 33681-33690
  • Peer Reviewed
• [Journal Article] A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. (2007)
  • Author(s): Nangaku M, Izuhara Y, Takizawa S, Yamashita T, Fujii-Kuriyama Y, Ohneda O, Yamamoto M, van Ypersele de Strihou C, Hirayama N, and Miyata T.
  • Journal Title: Arterioscler Thromb Vas Biol. 27 Pages: 2548-2554
  • Peer Reviewed
• [Journal Article] Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. (2007)
  • Author(s): Oshima M, Mimura J, Yamamoto M, and Fujii-Kuriyama Y.
  • Journal Title: Biochem Biophys Res Commun. 364 Pages: 276-282
  • Peer Reviewed
• [Journal Article] Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. (2007)
  • Author(s): Okitsu Y, Takahashi S, Minegishi N, Kameoka J, Kaku M, Yamamoto M, Sasaki T, and Harigae H
  • Journal Title: Biochem Biophys Res Commun. 364 Pages: 383-387
  • Peer Reviewed
• [Journal Article] Dysfunction of Nrf2 decreases KBrO_3-induced oxidative DNA damage in Oggl-null mice. (2007)
  • Author(s): Jaloszynski P, Murata S, Shinkai Y, Takahashi S, Kumagai Y, Nishimura S, and Yamamoto M.
  • Journal Title: Biochem Biophys Res Commun. 364 Pages: 966-971
  • Peer Reviewed
• [Journal Article] Carcinogenesis and transcriptional regulation through Maf recognition elements. (2007)
  • Author(s): Motohashi H, and Yamamoto M.
  • Journal Title: Cancer Sci. 98 Pages: 135-139
  • Peer Reviewed
• [Journal Article] Regulation of GATA1 gene expression. (2007)
  • Author(s): Kobayashi M, and Yamamoto M.
  • Journal Title: J Biochem. 142 Pages: 1-10
  • NAID: 10020097555
  • Peer Reviewed
• [Journal Article] Use of gene manipulated mice in the study of erythropoietin gene expression. (2007)
  • Author(s): Suzuki N, Obara N, and Yamamoto M.
  • Journal Title: Methods Enzymol. 435 Pages: 157-177
  • Peer Reviewed
• [Journal Article] 酸素センシングと赤血球造血シグナル (2007)
  • Author(s): 今川重彦、小原 直、鈴木教郎、山本雅之
  • Journal Title: 細胞 39 Pages: 537-540
  • Peer Reviewed
• [Journal Article] GATA因子スイッチングとGATA-1白血病 (2007)
  • Author(s): 清水律子、山本雅之
  • Journal Title: 生化学 79 Pages: 941-952
  • Peer Reviewed
• [Journal Article] 酸化ストレス防御のための生体内センサー: Keap1-Nrf2制御システム (2007)
  • Author(s): 田口恵子、山本雅之
  • Journal Title: 化学と生物 45 Pages: 857-862
  • NAID: 10019973647
  • Peer Reviewed
• [Journal Article] 食物と酸素由来の環境ストレスを感知するセンサー系 (2007)
  • Author(s): 大辻摩希子、山本雅之
  • Journal Title: 細胞工学 12月号 Pages: 1386-1390
  • Peer Reviewed
• [Journal Article] Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1 (2006)
  • Author(s): Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M
  • Journal Title: Mol Cell Biol 26 Pages: 221-229
• [Journal Article] Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer (2006)
  • Author(s): Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang M-I, Kobayashi A, Yokoyama S, Yamamoto M
  • Journal Title: Mol Cell 21 Pages: 689-700
• [Journal Article] Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model (2006)
  • Author(s): Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M
  • Journal Title: Mol Cell Biol 26 Pages: 2887-2900
• [Journal Article] Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements (2006)
  • Author(s): Yamamoto T, Kyo M, Kamiya T, Tanaka T, Engel JD, Motohashi M, Yamamoto M
  • Journal Title: Genes Cells 11 Pages: 575-591
• [Journal Article] MafG sumoylation is required for active transcriptional repression (2006)
  • Author(s): Motohashi H, Katsuoka F, Miyoshi C, Uchimura Y, Saitoh H, Francastel C, Engel JD, Yamamoto M
  • Journal Title: Mol Cell Biol Pages: 4652-4663
• [Journal Article] BRG1 Interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress (2006)
  • Author(s): Zhang J, Ohta T, Maruyama A, Hosoya T, Nishikawa K, Maher JM, Shibahara S, Itoh K, Yamamoto M
  • Journal Title: Mol Cell Biol 26 Pages: 7942-7952
• [Journal Article] Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species (2006)
  • Author(s): Kobayashi M, Yamamoto M
  • Journal Title: Adv Enz Regl Elsevier Science B.V., New York vol.46 Pages: 113-140
• [Journal Article] Two-site substrate recognition model for the Keap1-Nrf2 System: a hinge and latch mechanism (2006)
  • Author(s): Tong KI, Kobayashi A, Katsuoka F, Yamamoto M
  • Journal Title: Biol Chem 387 Pages: 1311-1320
• [Journal Article] Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. (2006)
  • Author(s): Kobayashi, A., et al.
  • Journal Title: Mol.Cell.Biol. 26 Pages: 221-229
• [Journal Article] Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. (2006)
  • Author(s): Okawa, H., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 339 Pages: 79-88
• [Journal Article] A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol. (2006)
  • Author(s): Umemura, T., et al.
  • Journal Title: Toxicol.Sci. 90 Pages: 111-119
• [Journal Article] Combinatorial Gata2 and Sca1 expression define hematopoietic stem cells in the bone marrow niche. (2006)
  • Author(s): Suzuki, N., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 103 Pages: 2202-2207
• [Journal Article] Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. (2006)
  • Author(s): Padmanabhan, B., et al.
  • Journal Title: Mol.Cell 21 Pages: 689-700
• [Journal Article] Keap1 recruits Neh2 through binding to ETGE and DLG motifs : characterization of the two-site molecular recognition model. (2006)
  • Author(s): Tong, K.I., et al.
  • Journal Title: Mol.Cell.Biol. (in press)
• [Journal Article] Nrf2 is a critical regulator of innate immune response and survival during experimental sepsis. (2006)
  • Author(s): Thimmulappa, R.K., et al.
  • Journal Title: J.Clin.Invest. (in press)
• [Journal Article] Real-time monitoring of stress erythropoiesis in vivo using Gata1- and β-globin LCR-luciferase transgenic mice. (2006)
  • Author(s): Suzuki, M., et al.
  • Journal Title: Blood (in press)
• [Journal Article] Nrf2 transcriptionally activates the mafG gene through an antioxidant response element (2005)
  • Author(s): Katsuoka F, Motohashi M, Engel JD, Yamamoto M
  • Journal Title: J Biol Chem 280 Pages: 4483-4490
• [Journal Article] Pi class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved regulatory element in zebrafish (2005)
  • Author(s): Suzuki T, Takagi Y, Osanai H, Li L, Takeuchi M, Katoh Y, Kobayashi M, Yamamoto M
  • Journal Title: Biochem J 388 Pages: 65-73
• [Journal Article] The distal sequence element of the selenocysteine tRNA gene is a tissue-dependant enhancer essential for mouse embryogenesis (2005)
  • Author(s): Kelly VP, Suzuki T, Nakajima O, Arai T, Tamai Y, Takahashi S, Nishimura S, Yamamoto M
  • Journal Title: Mol Cell Biol 25 Pages: 3658-3669
• [Journal Article] Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells (2005)
  • Author(s): Hosoya T, Maruyama A, Kang M-i, Kawatani Y, Shibata T, Uchida K, Itoh K, Yamamoto M
  • Journal Title: J Biol Chem 280 Pages: 27244-27250
• [Journal Article] Genetic evidence that small Maf proteins are essential for the activation of antioxidant response element-dependent genes (2005)
  • Author(s): Katsuoka F, Motohashi H, Ishii T, Aburatani H, Engel JD, Yamamoto M
  • Journal Title: Mol Cell Biol 25 Pages: 8044-8051
• [Journal Article] Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions (2005)
  • Author(s): Tauchi M, Hida A, Negishi T, Katsuoka F, Noda S, Mimura J, Hosoya H, Yanaka A, Aburatani H, Fujii-Kuriyama Y, Motohashi H, Yamamoto M
  • Journal Title: Mol Cell Biol 25 Pages: 9360-9368
• [Journal Article] Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema (2005)
  • Author(s): Iizuka T, Ishii Y, Itoh K, Kiwamoto T, Kimura T, Matsuno Y, Morishima Y, Hegab AE, Homma S, Nomura A, Sakamoto T, Shimura M, Yoshida A, Yamamoto M, Sekizawa K
  • Journal Title: Genes Cells 10 Pages: 1113-1125
• [Journal Article] Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress (2005)
  • Author(s): Yanaka A, Zhang S, Tauchi M, Suzuki H, Shibahara T, Matsui H, Nakahara A, Tanaka N, Yamamoto M
  • Journal Title: Inflammopharmacology 13 Pages: 83-90
• [Journal Article] Molecular mechanisms activating Nrf2-Keap1 pathway in regulation of antioxidant genes (2005)
  • Author(s): Kobayashi M, Yamamoto M
  • Journal Title: Antioxidants Redox Signaling 7 Pages: 384-395
• [Journal Article] Gene expression profiling of NRF2-mediated protection against oxidative injury. (2005)
  • Author(s): Cho, H-Y., et al.
  • Journal Title: Free Rad.Biol.Med. 38 Pages: 325-343
• [Journal Article] Transgenic overexpression of GATA-1 mutant lacking N-finger domain causes hemolytic syndrome in mouse erythroid cells. (2005)
  • Author(s): Nakano, M., et al.
  • Journal Title: Genes Cells 10 Pages: 47-62
• [Journal Article] Nrf2 transcriptionally activates the mafG gene through an antioxidant response element. (2005)
  • Author(s): Katsuoka, F., et al.
  • Journal Title: J.Biol.Chem. 280 Pages: 4483-4490
• [Journal Article] Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. (2005)
  • Author(s): Katoh, Y., et al.
  • Journal Title: Arch.Biochem.Biophys. 433 Pages: 342-350
• [Journal Article] Pi-class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved regulatory element in zebrafish. (2005)
  • Author(s): Suzuki, T., et al.
  • Journal Title: Biochem.J. 388 Pages: 65-73
• [Journal Article] UVA irradiation induces Nrf2 activation in dermal fibroblasts : Protective role in UVA-induced apoptosis. (2005)
  • Author(s): Hirota, A., et al.
  • Journal Title: J.Invest.Dermatol. 124 Pages: 825-832
• [Journal Article] GATA motifs regulate early hematopoietic lineage-specific expression of Gata2 gene. (2005)
  • Author(s): Kobayashi-Osaki, M., et al.
  • Journal Title: Mol.Cell.Biol. 280 Pages: 7005-7020
• [Journal Article] Differential responses of the Nrf2-Keapl system to laminar and oscillatory shear stresses in endothelial cells. (2005)
  • Author(s): Hosoya, T., et al.
  • Journal Title: J.Biol.Chem. 280 Pages: 27244-27250
• [Journal Article] Genetic evidence that small Maf proteins are essential for the activation of antioxidant response element-dependent genes. (2005)
  • Author(s): Katsuoka, F., et al.
  • Journal Title: Mol.Cell.Biol. 25 Pages: 8044-8051
• [Journal Article] Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions. (2005)
  • Author(s): Tauchi, M., et al.
  • Journal Title: Mol.Cell.Biol. 25 Pages: 9360-9368
• [Journal Article] Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema. (2005)
  • Author(s): Ishii, Y., et al.
  • Journal Title: J.Immunol 175 Pages: 6968-6975
• [Journal Article] Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. (2005)
  • Author(s): Iizuka, T., et al.
  • Journal Title: Genes Cells 10 Pages: 1113-1125
• [Journal Article] The distal sequence element of the selenocysteine tRNA gene is a tissue dependant enhancer essential for mouse embryogenesis. (2005)
  • Author(s): Kelly, V.P., et al.
  • Journal Title: Mol.Cell.Biol. 25 Pages: 3658-3669
• [Journal Article] Role of 15-deoxy Δ^<12-14> prostaglandin J_2 and Nrf2 pathways in protection against acute lung injury. (2005)
  • Author(s): Mochizuki, M., et al.
  • Journal Title: Am.J.Res.Cri.Care Med. 171 Pages: 1260-1266
• [Journal Article] Increased dose of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice. (2005)
  • Author(s): Yanagida, M., et al.
  • Journal Title: Oncogene 24 Pages: 4477-4485
• [Journal Article] Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway. (2005)
  • Author(s): Minegishi, N., et al.
  • Journal Title: Genes Cells 10 Pages: 693-704
• [Journal Article] Graded levels of GATA-1 expression modulate survival proliferation and differentiation of erythroid progenitors. (2005)
  • Author(s): Pan, X., et al.
  • Journal Title: J.Biol.Chem. 280 Pages: 22385-22394
• [Journal Article] Selective induction of a tumor marker glutathione S-transferase P1 by proteasome inhibitors. (2005)
  • Author(s): Usami, H., et al.
  • Journal Title: J.Biol.Chem. 280 Pages: 25267-25276
• [Journal Article] Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress. (2005)
  • Author(s): Yanaka, A., et al.
  • Journal Title: Inflammopharmacology 13 Pages: 83-90
• [Journal Article] Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance. (2005)
  • Author(s): Negishi, T., et al.
  • Journal Title: J.Immunol. 175 Pages: 7348-7356
• [Presentation] Molecular Basis of Oxidative Stress Response (2009)
  • Author(s): 山本雅之
  • Organizer: International Symposium on Inflammation and Redox Signaling
  • Place of Presentation: Culture Center, Seoul National University
  • Year and Date: 2009-11-21
• [Presentation] The Nrf2-Keap1 system and cancer chemoprevention (2009)
  • Author(s): 山本雅之
  • Organizer: Special seminar at the Korean Society of Cancer Prevention, Lee Gil Ya Cancer and Diabetes Institute
  • Place of Presentation: Incheon, Korea
  • Year and Date: 2009-11-20
• [Presentation] エリスロポエチンの産生細胞と発現制御 (2009)
  • Author(s): 山本雅之
  • Organizer: 5回長時間透析研究会ランチョンセミナー
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-08
• [Presentation] エリスロポエチン遺伝子の発現調節メカニズム (2009)
  • Author(s): 山本雅之
  • Organizer: 第18回 腎とエリスロポエチン研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-07
• [Presentation] 環境応答転写因子群と炎症・アレルギー (2009)
  • Author(s): 山本雅之
  • Organizer: 第59回 日本アレルギー学会秋季学術大会 特別企画シンポジウム2
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-29
• [Presentation] Mouse Models of GATA1-related Leukemia (2009)
  • Author(s): 山本雅之
  • Organizer: 14th International Association for Comparative Research on Leukemia, Related Diseases
  • Place of Presentation: Comprehensive Cancer Center, The Ohio State University
  • Year and Date: 2009-10-14
• [Presentation] The Nrf2-Keap1 System and Environmental Stress Response (2009)
  • Author(s): 山本雅之
  • Organizer: Kansas University
  • Place of Presentation: Kansas, USA
  • Year and Date: 2009-10-12
• [Presentation] Structural basis and cancer-related mutations of the Nrf2-Keapl system (2009)
  • Author(s): Yamamoto M
  • Organizer: John Hopkins University Seminar
  • Place of Presentation: JHU Baltimore, USA
  • Year and Date: 2009-09-17
• [Presentation] Nrf2-Keap1システムと肺疾患 (2009)
  • Author(s): 山本雅之
  • Organizer: 第12回 質性肺炎細胞分子病態研究会「慢性炎症機序と呼吸器疾患」
  • Place of Presentation: 東京
  • Year and Date: 2009-08-22
• [Presentation] The Nrf2-Keap1 system and oxidative stress response (2009)
  • Author(s): 山本雅之
  • Organizer: International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
  • Place of Presentation: Aso, Kumamoto
  • Year and Date: 2009-07-18
• [Presentation] 環境適応・応答の分子機構 (2009)
  • Author(s): 山本雅之
  • Organizer: 第18回 翠嶂会・近畿大学大学院医学研究科 ハイテクリサーチセンター合同公開シンポジウム「ヒト疾患モデル研究の新展開」
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-15
• [Presentation] Nrf2-Keap1系の分子構造基盤と発癌 (2009)
  • Author(s): 山本雅之
  • Organizer: 9回 日本蛋白質科学会年会シンポジウム
  • Place of Presentation: 熊本
  • Year and Date: 2009-05-20
• [Presentation] Molecular basis for the Nrf2-Keap1 system function (2009)
  • Author(s): 山本雅之
  • Organizer: Experimental Biology 2009
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] GATA factor switching during erythroid differentiation (2009)
  • Author(s): Masayuki Yamamoto, Takashi Moriguchi, Mikiko Suzuki, Ritsuko Shimizu
  • Organizer: Gordon Conference on Red Blood Cells
  • Place of Presentation: Biddeford, ME
• [Presentation] Regulation of erythropoietin gene expression in mouse (2009)
  • Author(s): Masayuki Yamamoto, Xiaoqing Pan, Syun Yamazaki, Ikuo Hirano, Naoko Minegishi, Norio Suzuki
  • Organizer: 8th International Luebeck Conference on the Pathophysiology and Pharmacology of Erythropoietin and other Hemopoietic Growth Factors
  • Place of Presentation: Luebeck, Germany
• [Presentation] Roles of HIF-binding sequences in chromatin dynamics during activation of the hypoxia-inducible genes (2009)
  • Author(s): Norio Suzuki, Orjan Wrange, Katarina Gradin, Sergey Belikov, Kian Leong Lee, Masayuki Yamamoto, Lorenz Poellinger
  • Organizer: 8th International Luebeck Conference on the Pathophysiology and Pharmacology of Erythropoietin and other Hemopoietic Growth Factors
  • Place of Presentation: Luebeck, Germany
• [Presentation] Structural Basis of Nrf2-Keap1 Function (2009)
  • Author(s): 山本雅之
  • Organizer: Dasan 2009 Conferece on Bioremodelling
  • Place of Presentation: Jeju, Korea
• [Presentation] 酸化ストレス応答と病態 (2009)
  • Author(s): 山本雅之
  • Organizer: 第7回 Vascular and Brain Conference
  • Place of Presentation: 大阪
• [Presentation] 含セレン蛋白質とNrf2による2段階生体防御機構 (2009)
  • Author(s): 鈴木隆史、川谷幸恵、Vincent Kelly、山本雅之
  • Organizer: 第62回 日本酸化ストレス学会
  • Place of Presentation: 福岡
• [Presentation] 遺伝子組換え実験および遺伝子組み換え動物モデルと医学研究の発展 (2009)
  • Author(s): Masayuki Yamamoto, Tatsuhiro Shibata, Ohta Tsutomu, Kit Tong, Hirofumi Kurokawa, Takafumi Suzuki, Keiko Taguchi, Hozumi Motohashi
  • Organizer: 第68回 日本癌学会学術総会シンポジウム
  • Place of Presentation: 横浜
• [Presentation] Nrf2-Keap1系と発癌 (2009)
  • Author(s): 山本雅之
  • Organizer: 68回 日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] セレン蛋白質とNrf2による酸化ストレスに対する2段階防御 (2009)
  • Author(s): 鈴木隆史、川谷幸恵、Vincent Kelly、山本雅之
  • Organizer: 第82回 日本生化学会
  • Place of Presentation: 神戸
• [Presentation] The Nrf2-Keap1 System and Cancer (2009)
  • Author(s): 山本雅之
  • Organizer: 20th Asia Pacific Cancer Conference
  • Place of Presentation: つくば
• [Presentation] Nrf2-Keap1環境応答系機能の分子・構造基盤 (2009)
  • Author(s): 山本雅之
  • Organizer: 蛋白研セミナー「活性酸素のシグナル伝達」
  • Place of Presentation: 大阪
• [Presentation] Structural basis and cancer-related mutations of the Nrf2-Keapl system (2008)
  • Author(s): Yamamoto M
  • Organizer: Scientific Colloquium, PHILIP MORRIS Research Laboratories GmbH
  • Place of Presentation: Koln, Germany
  • Year and Date: 2008-09-26
• [Presentation] The Nrf2-Keapl Stress Response System : Molecular Basis of Adaptive Responses to Food and Oxygen (2008)
  • Author(s): Yamamoto M
  • Organizer: 11-SAC Seminar
  • Place of Presentation: Danilovskaya Hotel, Moscow, Russian
• [Presentation] Gata1 Gene Regulation and GATA1-related Leukemia (2008)
  • Author(s): Yamamoto M, Moriguchi T, Suzuki M. and Shimizu R
  • Organizer: The 16th Conference on Hemoglobin Switching Asilomar
  • Place of Presentation: California, USA
• [Presentation] Induction of Hyperproliferative Fetal Megakaryopoiesis by an N-terminally Truncated GATA1 Mutant (2008)
  • Author(s): Shimizu R, Engel JD, and Yamamoto M
  • Organizer: The 16th Conference on Hemoglobin Switching, Asilomar
  • Place of Presentation: California, USA
• [Presentation] The Nrf2-Keap1 System and Cancer (2008)
  • Author(s): Yamamoto M
  • Organizer: AACR conference on "Chemical and Biological Aspect of Inflammation and Cancer"
  • Place of Presentation: JW Marriott Ihilani Resort & Spa at Ko Olina, Hawaii, USA
• [Presentation] The Nrf2-Keap 1 system of oxidative/electrophilic stress response: mechanism and diseases. (2008)
  • Author(s): Tong KI., Yamamoto M
  • Organizer: Joint Annual Meeting of the Molecular Biology Society of Japan and the Japanese Biochemical Society. 2008(BMB2008)
  • Place of Presentation: Kobe Port Island, Japan
• [Presentation] The environmental response to food and oxygen. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: JST-ERATO Environmental Response Project International Symposium on "The Environmental Response".
  • Place of Presentation: EPOCHAL Tsukuba International Congress Center, Tsukuba
  • Year and Date: 2007-12-21
• [Presentation] Molecular Mechanisms of Adaptive Responses to Food and Oxygen. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: The International Conference on Food Factors for Health Promotion (ICOFF2007)
  • Place of Presentation: Kyoto
  • Year and Date: 2007-11-29
• [Presentation] 酸化ストレス応答の分子基盤と疾患 (2007)
  • Author(s): 山本雅之
  • Organizer: CKDと心血管イベントExpert Meeting特別講演
  • Place of Presentation: 東京會舘
  • Year and Date: 2007-11-27
• [Presentation] 親電子性物質・酸化ストレス応答の分子機構 (2007)
  • Author(s): 山本雅之
  • Organizer: 第7回 システム生物医学研究会
  • Place of Presentation: 東京大学先端科学技術研究センター システム生物医学ラボラトリー主催、箱根湯本
  • Year and Date: 2007-11-21
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 東海医学会講演会
  • Place of Presentation: 東海大学
  • Year and Date: 2007-11-13
• [Presentation] The Nrf2-Keap1 Stress Response System. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: The 23rd Kumamoto Medical Bioscience Symposium on New Insights into Metabolic Disorders and Vascular Disease.
  • Place of Presentation: Kumamoto
  • Year and Date: 2007-11-12
• [Presentation] GATA因子と白血病 (2007)
  • Author(s): 山本雅之
  • Organizer: 第2回つくば医科学研究交流会ランチョンセミナー
  • Place of Presentation: 三菱化学つくばクリエーションセンター
  • Year and Date: 2007-11-10
• [Presentation] Two-site substrate recognition model for the Keapl-Nrf2 system: a hinge and latch mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: Distinguished Professor's Seminar.
  • Place of Presentation: University of Arizona, Tucson, USA
  • Year and Date: 2007-11-02
• [Presentation] Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechani sm. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: Adjunct Professor Lecture at Johns Hopkins University Blumberg School of Public Health, Baltimore
  • Place of Presentation: Johns Hopkins University Blumberg School of Public Health, Baltimore, USA
  • Year and Date: 2007-10-31
• [Presentation] Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: NIEHS Seminar.
  • Place of Presentation: Research Triangle Park(RTP), USA
  • Year and Date: 2007-10-30
• [Presentation] Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: National University of Singapore-Tohoku University/Centre of Excellence Joint Symposium"Basic and Clinical Research on Signal Transduction Diseases"
  • Place of Presentation: Centre for Life Sciences, National University of Singapore, Singapore, Singapore
  • Year and Date: 2007-09-05
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 臨床研セミナー
  • Place of Presentation: (財)東京都医学研究機構 東京都臨床医学総合研究所
  • Year and Date: 2007-08-10
• [Presentation] Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: The 3^<rd> DECODE for Biological Responses International Meeting.
  • Place of Presentation: Odaiba, Tokyo
  • Year and Date: 2007-08-04
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 第5回フリーラジカルと脳疾患 東日本研究会特別講演
  • Place of Presentation: 経団連会館、大手町
  • Year and Date: 2007-07-28
• [Presentation] 環境応答の分子機構 (2007)
  • Author(s): 山本雅之
  • Organizer: 第5回RCGMフロンティアシンポジウム「ゲノム医学一基礎から未来医療へ」
  • Place of Presentation: 埼玉医科大学日高キャンパス創立30周年記念講堂、日高市
  • Year and Date: 2007-07-27
• [Presentation] GATA転写因子群の機能異常と白血病 (2007)
  • Author(s): 山本雅之
  • Organizer: 第17回 日本産婦人科・新生児血液学会シンポジウム「ダウン症候群と一過性骨髄造血(TAM)」
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2007-06-30
• [Presentation] 細胞の癌化とその抑制における転写因子の役割 (2007)
  • Author(s): 山本雅之
  • Organizer: 文部科学省がん特定領域研究「遺伝情報システム異常と発がん」
  • Place of Presentation: 癌研究会吉田富三記念講堂、有明
  • Year and Date: 2007-06-30
• [Presentation] 親電子性物質・酸化ストレス応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 循環器内科リサーチセミナー
  • Place of Presentation: 東北大学
  • Year and Date: 2007-05-30
• [Presentation] 親電子性物質・活性酸素応答の分子メカニズム (2007)
  • Author(s): 山本雅之
  • Organizer: 日本生化学会東北支会シンポジウム
  • Place of Presentation: 艮陵会館、仙台
  • Year and Date: 2007-05-12
• [Presentation] 酸化ストレス応答と呼吸器疾患 (2007)
  • Author(s): 山本雅之
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京フォーラム
  • Year and Date: 2007-05-11
• [Presentation] GATA転写因子群の機能異常と白血病 (2007)
  • Author(s): 山本雅之
  • Organizer: 第50回 東北小児白血病研究会
  • Place of Presentation: かんぽヘルスプラザ仙台
  • Year and Date: 2007-04-28
• [Presentation] Functional analyses of GATA-2 with knockdown and conditional knockout mice. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: EMBO WORKSHOP ON The Role and Control of GATA Fact ors in Tissue Development and Disease.
  • Place of Presentation: Capri, Italy
• [Presentation] Genetic Analysis of Mouse GATA-related Leukemia and Leukemic Stem Cells. (2007)
  • Author(s): Masayuki Yamamoto.
  • Organizer: Gordon Research Conference on Red Cells, Centre Paul Langevin in Aussois.
  • Place of Presentation: Aussois, France
• [Book] Keap1-Nrf2システムによる酸化ストレス・親電子性物質応答機構「酸化ストレスの医学」 (2008)
  • Author(s): 小林聡・山本雅之
  • Publisher: 診断と治療社
• [Book] 転写制御とエピジェネティクス-ゲノムでコードに向けて- (2008)
  • Author(s): 鈴木隆史、山本雅之
  • Publisher: 南山堂
• [Remarks]
  • URL: http://dmbc.med.tohoku.ac.jp/official/index.html
• [Remarks]
  • URL: http://dmbc.med.tohoku.ac.jp/official/index.html