| Budget Amount *help |
¥147,500,000 (Direct Cost: ¥147,500,000)
Fiscal Year 2009: ¥29,500,000 (Direct Cost: ¥29,500,000)
Fiscal Year 2008: ¥29,500,000 (Direct Cost: ¥29,500,000)
Fiscal Year 2007: ¥29,500,000 (Direct Cost: ¥29,500,000)
Fiscal Year 2006: ¥29,500,000 (Direct Cost: ¥29,500,000)
Fiscal Year 2005: ¥29,500,000 (Direct Cost: ¥29,500,000)
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| Research Abstract |
Receptor-tyrosine kinases play critical roles in cancer development. We identified Tob as a signaling molecule downstream of the receptor-tyrosine kinases. Through molecular and cellular biological analysis and the analysis of gene-engineered mice, we provided evidence that Tob is involved in regulation of cell proliferation, cell death, and energy metabolism by interacting with other cellular proteins such as Ndr family kinases and a large protein complex that regulates messenger RNA turn over.
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