The role of the nuclear receptors in cancer development

• Project/Area Number: 17013023
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: KATO Shigeaki The University of Tokyo, 分子細胞生物学研究所, 教授 (60204468)
• Co-Investigator(Kenkyū-buntansha): TAKEYAMA Ken-ichi 東京大学, 分子細胞生物学研究所, 講師 (30323570) ; KITAGAWA Hirochika 東京大学, 分子細胞生物学研究所, 特任講師 (20345234) ; TAKADA Ichiro 東京大学, 分子細胞生物学研究所, 助教 (50361655) ; OHTAKE Fumiaki 東京大学, 分子細胞生物学研究所, 助教 (60447373)
• Co-Investigator(Renkei-kenkyūsha): TAKEYAMA Ken-chi 東京大学, 分子細胞生物学研究所, 講師 (30323570) ; KITAGAWA Hirochika 東京大学, 分子細胞生物学研究所, 特任講師 (20345234) ; OHTAKE Fumiaki 東京大学, 分子細胞生物学研究所, 助教 (60447373)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥47,600,000 (Direct Cost: ¥47,600,000); Fiscal Year 2009: ¥8,800,000 (Direct Cost: ¥8,800,000); Fiscal Year 2008: ¥8,800,000 (Direct Cost: ¥8,800,000); Fiscal Year 2007: ¥10,000,000 (Direct Cost: ¥10,000,000); Fiscal Year 2006: ¥10,000,000 (Direct Cost: ¥10,000,000); Fiscal Year 2005: ¥10,000,000 (Direct Cost: ¥10,000,000)
• Keywords: 転写制御 / 細胞周期依存的 / 核内因子複合体群 / 性ホルモン受容体 / ホルモン非依存性 / 変異男性ホルモン受容体 / 核内受容体共役因子 / 染色体構造調節 / ホルモン受容体 / 性ホルモン非依存性 / ホルモン依存性癌 / ホルモン非依存性癌 / 前立腺特異的AR欠損マウス / 転写共役因子 / 異変男性ホルモン受容体

Research Abstract

Selective estrogen receptor modulator (SERM) is a well-established agent in the management of hormone-dependent cancer such as breast, endometrial and ovarian cancer. SERM liganded-ERα regulates its target genes in tissue specific manner. However, the molecular mechanism which determines the tissue specificity is not well-known. We used biochemical purification techniques to identify ERα-associated proteins dependently on SERM. Interestingly, we found that bromodomain-containing protein BRD4, which is known to recruit positive transcription elongation factor b (P-TEFb) on target gene promoters and stimulates transcriptional elongation.

Research Products

• [Journal Article] Histone chaperone DEK coactivates a nuclear receptor: a functional link to leukemia. (2010)
  • Author(s): Sawatsubashi, S., Murata, T., Lim, J., Fujiki, R., Ito, S., Suzuki, E., Tanabe, M., Zhao, Y., Kimura, S., Fujiyama, S., Ueda, T., Umetsu, D., Ito, T., Takeyama, K., Kato, S.
  • Journal Title: Genes Dev. 24 Pages: 159-170
  • Peer Reviewed
• [Journal Article] Histone chaperone DEK coactivates a nuclear receptor : a functional link to leukemia (2010)
  • Author(s): Sawatsubashi, S., Murata, T., Lim, J., Fujiki, R., Ito, S., Suzuki, E., Tanabe, M., Zhao, Y., Kimura, S., Fujiyama, S., Ueda, T., Umetsu, D., Ito, T., Takeyama, K., Kato, S.
  • Journal Title: Genes Dev. 24 Pages: 159-170
  • Peer Reviewed
• [Journal Article] DNA demethylation in hormone-induced transcriptional derepression. (2009)
  • Author(s): Kim, M., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S., Matsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., Kitagawa, H., Takeyama, K., Shibuya, H., Ohtake, F., Kato, S.
  • Journal Title: Nature 461 Pages: 1007-1012
  • Peer Reviewed
• [Journal Article] GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. (2009)
  • Author(s): Fujiki, R., Chikanishi, T., Hashiba, W., Ito, H., Takada, I., Roeder, R.G., Kitagawa, H., Kato, S.
  • Journal Title: Nature 459 Pages: 455-459
  • Peer Reviewed
• [Journal Article] Phosphorylation of WSTF by MAPK induces a switching between two distinct chromatin remodeling complexes. (2009)
  • Author(s): Oya, H., Yokoyama, A., Yamaoka, I., Fujiki, R., Yonezawa, M., Youn, M. -Y., Takada, I., Kato, S., Kitagawa, H.
  • Journal Title: J. Biol. Chem. 284 Pages: 32472-32482
  • Peer Reviewed
• [Journal Article] Maturation of microRNA is hormonally regulated by a nuclear receptor. (2009)
  • Author(s): Yamagata, K., Fujiyama, S., Ito, S., Ueda, T., Murata, T., Naitou, M., Takeyama, K., Minami, Y., O'Malley, B.W., Kato, S.
  • Journal Title: Mol. Cell 36 Pages: 340-347
  • Peer Reviewed
• [Journal Article] Coactivation of estrogen receptorβby gonadotropin-induced cofactor GIOT-4. (2009)
  • Author(s): Kouzu-Fujita, M., Mezaki, Y., Mtsumoto, T., Yamaoka, I., Sawatsubashi, S., Yano, T., Taketani, Y., Kitagawa, H., Kato, S.
  • Journal Title: Mol. Cell. Biol. 29 Pages: 83-92
  • Peer Reviewed
• [Journal Article] Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). (2009)
  • Author(s): Yoshimura, K., Kitagawa, H., Fujiki, R., Tanabe, M., Takezawa, S., Takada, I., Yamaoka, I., Yonezawa, M., Kondo, T., Furutani, Y., Yagi, H., Yoshinaga, S., Masuda, T., Fukuda, T., Yamamoto, Y., Ebihara, K., Li, D. Y., Matsuoka, R., Takeuchi, J. K., Matsumoto, T., Kato, S.
  • Journal Title: Proc. Natl. Acad. Sci. USA 106 Pages: 9280-9285
  • Peer Reviewed
• [Journal Article] Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity. Proc. (2009)
  • Author(s): Suzuki, E., Zhao, Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Fujiyama, S., Lim, J., Matsukawa, H., Kouzmenko, A.P., Aigaki, T., Tabata, T., Takeyama, K., Kato, S.
  • Journal Title: Natl. Acad. Sci. USA 106 Pages: 3818-3822
  • Peer Reviewed
• [Journal Article] BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. (2009)
  • Author(s): Fujiyama-Nakamura, S., Ito, S., Sawatsubashi, S., Yamauchi, Y., Suzuki, E., Tanabe, M., Kimura, S., Murata, T., Isobe, T., Takeyama, K., Kato, S
  • Journal Title: Genes to Cells 14 Pages: 965-973
  • Peer Reviewed
• [Journal Article] Modulation of microRNA processing by p53. (2009)
  • Author(s): Suzuki, H.I., Yamagata, K., Sugimoto, K., Iwamoto, T., Kato, S., Miyazono, K.
  • Journal Title: Nature 460 Pages: 529-533
  • Peer Reviewed
• [Journal Article] Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. (2009)
  • Author(s): Kawajiri, K., Kobayashi, Y., Ohtake, F., Ikuta, T., Matsushima, Y., Mimura, J., Pettersson, S., Pollenz, R.S., Sakaki, T., Hirokawa, T., Akiyama, T., Kurosumi, M., Poellinger, L., Kato, S., Fujii-Kuriyama, Y.
  • Journal Title: Proc. Natl. Acad. Sci. USA 106 Pages: 13481-13486
  • Peer Reviewed
• [Journal Article] Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. (2009)
  • Author(s): Zhang, Z., Hener, P., Frossard, N., Kato, S., Metzger, D., Li, M., Chambon, P.
  • Journal Title: Proc. Natl. Acad. Sci. USA 106 Pages: 1536-1541
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• [Journal Article] Embryonic hair follicle fate change by augmented beta-catenin through Shh and Bmp signaling. (2009)
  • Author(s): Suzuki, K., Yamaguchi, Y., Villacorte, M., Mihara, K., Akiyama, M., Shimizu, H., Taketo, M.M., Nakagata, N., Tsukiyama, T., Yamaguchi, T.P., Birchmeier, W., Kato, S., Yamada, G.
  • Journal Title: Development 136 Pages: 367-372
  • Peer Reviewed
• [Journal Article] The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice. (2009)
  • Author(s): Iwasawa, M,, Miyazaki, T., Nagase, Y., Akiyama, T., Kadono, Y., Nakamura, M., Oshima, Y., Yasui, T., Matsumoto, T,. Nakamura, T., Kato, S., Hennighausen, L., Nakamura, K., Tanaka, S.
  • Journal Title: J. Clin. Invest1. 19 Pages: 3149-3159
  • Peer Reviewed
• [Journal Article] Phosphorylation of WSTF by MAPK induces a switching between two distinct chromatin remodeling complexes (2009)
  • Author(s): Oya, H., Yokoyama, A., Yamaoka, I., Fujiki, R., Yonezawa, M., Youn, M.-Y., Takada, I., Kato, S., Kitagawa, H.
  • Journal Title: J.Biol.Chem. 284 Pages: 32472-32482
  • Peer Reviewed
• [Journal Article] GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis (2009)
  • Author(s): Fujiki, R., Chikanishi, T., Hashiba, W., Ito, H., Takada, I., Roeder, R.G., Kitagawa, H., Kato, S.
  • Journal Title: Nature 459 Pages: 455-459
  • Peer Reviewed
• [Journal Article] Nuclear protein GlcNAcylation facilitates retinoic acid-induced granulopoiesis through histone activating methylation (2009)
  • Author(s): Fujiki, R., Chikanishi, T., Hashiba, W., Ito. H., Takada, I., Roeder, R. G., Kitagawa, H. and Kato.S.
  • Journal Title: Nature (掲載確定)(in press)
  • Peer Reviewed
• [Journal Article] Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity (2009)
  • Author(s): Suzuki, E., Zhao, Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Fujiyama, S., Lim, J., Matsukawa, H., Kouzmenko, A., Aigaki, T., Tabata, T., Takeyama, K. and Kato. S.
  • Journal Title: Proc. Natl. Acad. Sci. USA 106 Pages: 3818-3822
  • Peer Reviewed
• [Journal Article] Nuclear protein GlcNAcylation facilitates retinoic acid-induced granulopoiesis through histone activating methylatio (2009)
  • Author(s): Fujiki, R., Chikanishi, T., Hashiba, W, Ito, H., Takada, I., Roeder, R. G., Kitagawa, H., and Kato, S.
  • Journal Title: Nature (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity (2009)
  • Author(s): Suzuki, E., Zhao, Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Fujiyama, S., Lim, J., Matsukawa, H., Kouzmenko, A., Aigaki, T., Tabata, T., Takeyama, K. and Kato, S.
  • Journal Title: Proc. Natl. Acad. Sci. USA (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD. (2008)
  • Author(s): Tanabe, M., Kouzmenko, A., Ito, S., Sawasubashi, S., Suzuki, E., Fujiyama, S., Yamagata, K., Zhao, Y., Kimura, S., Ueda, T., Murata, T., Matsukawa, H., Takeyama, K., Kato, S.
  • Journal Title: Genes to Cells 13 Pages: 1279-1288
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• [Journal Article] A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (2008)
  • Author(s): Zhao, Y., Lang, G., Ito, S., Bonnet, J., Metzger, E., Sawatsubashi, S., Suzuki, E., Le Guezennec, X., Stunnenberg, H.G., Krasnov, A., Georgieva, S.G., Schule, R., Takeyama, K., Kato, S., Tora, L., Devys, D.
  • Journal Title: Mol. Cell 29 Pages: 92-101
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• [Journal Article] Switching of chromatin-remodelling complexes for oestrogen receptor-alpha. (2008)
  • Author(s): Okada, M., Takezawa, S., Mezaki, Y., Yamaoka, I., Takada, I., Kitagawa, H., Kato, S.
  • Journal Title: EMBO Rep. 9 Pages: 563-568
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• [Journal Article] Transrepressive function of TLX requires the histone demethylase LSD1. (2008)
  • Author(s): Yokoyama, A., Takezawa, S., Schule, R., Kitagawa, H., Kato, S.
  • Journal Title: Mol. Cell. Biol. 28 Pages: 3995-4003
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• [Journal Article] Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor. (2008)
  • Author(s): Kimura, S., Sawatsubashi, S., Ito, S., Kouzmenko, A., Suzuki, E., Zhao, Y., Yamagata, K., Tanabe, M., Ueda, T., Fujiyama, S., Murata, T., Matsukawa, H., Takeyama, K., Yaegashi, N., Kato, S.
  • Journal Title: Biochem. Biophys. Res. Commun. 371 Pages: 889-893
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• [Journal Article] Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings. Biochem. (2008)
  • Author(s): Ohtake, F., Baba, A., Fujii-Kuriyama, Y., Kato, S.
  • Journal Title: Biophys. Res. Commun. 370 Pages: 541-546
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• [Journal Article] Spermatogenesis-specific association of SMCY and MSH5. (2008)
  • Author(s): Akimoto, C., Kitagawa, H., Matsumoto, T., Kato, S.
  • Journal Title: Genes to Cells 13 Pages: 623-633
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• [Journal Article] Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli. (2008)
  • Author(s): Kouzmenko, A.P., Takeyama, K., Kawasaki, Y., Akiyama, T., Kato, S.
  • Journal Title: Oncogene 27 Pages: 4888-4899
  • Peer Reviewed
• [Journal Article] Switching of chromatin-remodelling complexes for oestrogen receptor-alpha (2008)
  • Author(s): Okada, M., Takezawa, S., Mezaki, Y., Yamaoka, I., Takada, I., Kitagawa, H. and Kato. S.
  • Journal Title: EMBO Rep. 9 Pages: 563-568
  • Peer Reviewed
• [Journal Article] Switching of chromatin-remodelling complexes for oestrogen receptor-alpha (2008)
  • Author(s): Okada, M., Takezawa, S., Mezaki, Y., Yamaoka, I., Takada, I., Kitagawa, H. and Kato, S.
  • Journal Title: EMBO Rep. 9 Pages: 563-568
  • Peer Reviewed
• [Journal Article] A reduction state potentiates the glucocorticoid response through receptor protein stabilization. (2007)
  • Author(s): Kitagawa, H., Yamaoka, I., Akimoto, C., Kase, I., Mezaki, Y., Shimizu, T., Kato, S.
  • Journal Title: Genes to Cells 12 Pages: 1281-1287
  • Peer Reviewed
• [Journal Article] A histone lysine methyltransferase activated by non-canonical Wnt signaling suppresses PPAR-γtransactivation. (2007)
  • Author(s): Takada, I., Mihara, M., Suzawa, M., Ohtake, F., Igarashi, M., Takeyama, K., Nakamura, T., Mezaki, Y., Takezawa, S., Yogiashi, Y., Kitagawa, H., Yamada, G., Takada, S., Minami, Y., Shibuya, H., Matsumoto, K., Kato, S.
  • Journal Title: Nat. Cell Biol. 9 Pages: 1273-1285
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• [Journal Article] Vitamin K induces osteoblast differentiation through PXR-mediated transcriptional control of the Msx2 gene. (2007)
  • Author(s): Igarashi, M., Yogiashi, Y., Mihara, M., Takada, I., Kitagawa, H., Kato, S.
  • Journal Title: Mol. Cell. Biol. 27 Pages: 7947-7954
  • Peer Reviewed
• [Journal Article] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. (2007)
  • Author(s): Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A., Nohara, K., Chiba, T., Fujii-Kuriyama, Y., Kato, S.
  • Journal Title: Nature 446 Pages: 562-566
  • NAID: 40015761666
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• [Journal Article] DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of MicroRNAs. (2007)
  • Author(s): Fukuda, T., Yamagata, K., Fujiyama, S., Matsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Nakamura, T., Akimoto, C., Yamamoto, Y., Katagiri, T., Foulds, C., Takezawa, S., Kitagawa, H., Takeyama, K., O'Malley, B.W., Kato, S.
  • Journal Title: Nat. Cell Biol. 9 Pages: 604-611
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• [Journal Article] A cell cycle-dependent co-repressor for photoreceptor cell-specific nuclear receptor function. (2007)
  • Author(s): Takezawa, S., Yokoyama, A., Okada, M., Fujiki, R., Iriyama, A., Yanagi, Y., Ito, H., Takada, I., Kishimoto, M., Miyajima, A., Takeyama, K., Umesono, K., Kitagawa, H., Kato, S.
  • Journal Title: EMBO J. 26 Pages: 764-774
  • Peer Reviewed
• [Journal Article] Pituitary function of androgen receptor constitutes a glucocorticoid production circuit. (2007)
  • Author(s): Miyamoto, J., Matsumoto, T., Shiina, H., Inoue, K., Takada, I., Ito, S., Itoh, J., Minematsu, T., Sato, T., Yanase, T., Nawata, H., Osamura, R.Y., Kato, S.
  • Journal Title: Mol. Cell. Biol. 27 Pages: 4807-4814
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• [Journal Article] 1α, 25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 gene. (2007)
  • Author(s): Kim, M. -S., Fujiki, R., Kitagawa, H., Kato, S.
  • Journal Title: Mol. Cell. Endocrinol. 265-266 Pages: 168-173
  • Peer Reviewed
• [Journal Article] 1alpha, 25(OH)2D3 -induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter. (2007)
  • Author(s): Kim, M. -S., Fujiki, R., Murayama, A., Kitagawa, H., Yamamoto, K., Yamamoto, Y., Mihara, M., Takeyama, K., Kato, S.
  • Journal Title: Mol. Endocrinol. 21 Pages: 334-342
  • Peer Reviewed
• [Journal Article] Androgen receptor functions in male and female reproduction. (2007)
  • Author(s): Matsumoto, T., Kawano, H., Shiina, H., Sato, T., Kato, S.
  • Journal Title: Reproductive Med. Biol. 6 Pages: 11-17
  • NAID: 10018849528
  • Peer Reviewed
• [Journal Article] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase (2007)
  • Author(s): Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A., Nohara, K., Chiba, T., Fujii-Kuriyama, Y., Kato, S.
  • Journal Title: Nature 446 Pages: 562-566
  • NAID: 40015761666
• [Journal Article] DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of MicroRNAs (2007)
  • Author(s): Fukuda, T., Yamagata, K., Fujiyama, S., Matsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Nakamura, T., Akimoto, C., Yamamoto, Y., Katagiri, T., Foulds, C., Takezawa, S., Kitagawa, H., Takeyama, K., O Malley, B.W., Kato, S.
  • Journal Title: Nat. Cell Biol. (in press)
• [Journal Article] A cell cycle-dependent co-repressor for photoreceptor cell-specific nuclear receptor function (2007)
  • Author(s): Takezawa, S., Yokoyama, A., Okada, M., Fujiki, R., Iriyama, A., Yanagi, Y., Ito, H., Takada, I., Kishimoto, M., Miyajima, A., Takeyama, K., Umesono, K., Kitagawa, H., Kato, S.
  • Journal Title: EMBO J. 26 Pages: 764-774
• [Journal Article] An hGCN5/TRRAP HAT complex coactivates BRCA1 transactivation function through histone modification. (2006)
  • Author(s): Oishi, H., Kitagawa, H., Wada, O., Takezawa, S., Tora, L., Kouzu-Fujita, M., Takada, I., Yano, T., Yanagisawa, J., Kato, S.
  • Journal Title: J. Biol. Chem. 281 Pages: 20-26
  • Peer Reviewed
• [Journal Article] Premature ovarian failure in androgen receptor-deficient mice (2006)
  • Author(s): Shiina, H., Matsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., Sakari, M., Takada, I., Nakamura, T., Metzger, D., Chambon, P., Kanno, J., Yoshikawa.H., Kato, S.
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 224-229
• [Journal Article] 1alpha, 25(OH)2D3 -induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter. (2006)
  • Author(s): Kim, M.-S., Fujiki, R., Murayama, A., Kitagawa, H., Yamamoto, K., Yamamoto, Y., Mihara, M., Takeyama, K., Kato, S.
  • Journal Title: Mol. Endocrinol. 21 Pages: 334-342
• [Journal Article] An hGCN5/TRRAP HAT complex coactivates BRCA1 transactivation function through histone modification (2006)
  • Author(s): Oishi, H., Kitagawa, H., Wada, O., Takezawa, S., Tora, L., Kouzu-Fujita, M., Takada, I., Yano, T., Yanagisawa, J., Kato, S.
  • Journal Title: J. Biol. Chem. 281 Pages: 20-26
• [Journal Article] Premature ovarian failure in androgen receptor-deficient mice (2006)
  • Author(s): Shiina, H., Matsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., Sakari, M., Takada, I., Nakamura, T., Metzger, D., Chambon, P., Kanno, J., Yoshikawa, H., Kato, S.
  • Journal Title: Proc.Natl.Acad.Sci.USA 103 Pages: 224-229
• [Journal Article] An hGCN5/TRRAP HAT complex coactivates BRCA1 transactivation function through histone modification (2006)
  • Author(s): Oishi, H., Kitagawa, H., Wada, O., Takezawa, S., Tora, L., Kouzu-Fujita, M., Takada, I., Yano, T., Yanagisawa, J., Kato, S.
  • Journal Title: J.Biol.Chem. 281 Pages: 20-26
• [Journal Article] TRRAP as a hepatic coactivator of LXR and FXR function. Biochem. (2005)
  • Author(s): Unno, A., Takada, I., Takezawa, S., Oishi, H., Baba, A., Shimizu, T., Tokita, A., Yanagisawa, J., Kato, S.
  • Journal Title: Biophys. Res. Commun. 327 Pages: 933-938
  • Peer Reviewed
• [Journal Article] A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line. Biosci. (2005)
  • Author(s): Furutani, T., Takeyama, K., Koutoku, H., Ito, S., Taniguchi, N., Suzuki, E., Kudoh, M., Shibasaki, M., Shikama, H., Kato, S.
  • Journal Title: Biotechnol. Biochem. 69 Pages: 2236-2239
  • Peer Reviewed
• [Journal Article] 1α, 25-dihydroxyvitamin D3 is a preventive factor in the metastasis of lung cancer. (2005)
  • Author(s): Nakagawa, K., Kawaura, A., Kato, S., Takeda, E., Okano, T.
  • Journal Title: Carcinogenesis 26 Pages: 429-440
  • Peer Reviewed
• [Journal Article] The DNA mismatch repair gene hMSH2 is a potent coacytivator or oestrogen receptorα. (2005)
  • Author(s): Wada-Hiraike, O., Yano, T., Nei, T., Matsumoto, Y., Nagasaka, K., Takizawa, S., Oishi, H., Arimoto, T., Nakagawa, S., Yasugi, T., Kato, S., Taketani, Y.
  • Journal Title: Br. J. Cancer 92 Pages: 2286-2291
  • Peer Reviewed
• [Journal Article] Splicing potentiation by growth factor signals via estrogen receptor phosphorylation (2005)
  • Author(s): Masuhiro, Y., Mezaki, Y.Sakari, M., Takeyama, K., Yoshida, T., Inoue, K., Yanagisawa, J., Hanazawa, S., O'Malley, B.W., Kato, S.
  • Journal Title: Proc.Natl.Acad.Sci.USA 102 Pages: 8126-8131
• [Journal Article] Ligand-induced transrepression by VDR through association of WSTF with acetylated histones (2005)
  • Author(s): Fujiki, R., Kim, M., Sasaki, Y., Yoshimura, K., Kitagawa, H., Kato, S.
  • Journal Title: EMBO J. 24 Pages: 3881-3894
• [Journal Article] Repressive domain of unliganded human estrogen receptor α associates with Hsc70 (2005)
  • Author(s): Ogawa, S., Oishi, H., Mezaki, Y., Kouzu-Fujita, M., Matsuyama, R., Nakagomi, M., Mori, E., Murayama, E., Nagasawa, H., Kitagawa, H., Yanagisawa.J., Kato, S.
  • Journal Title: Genes to Cells 10 Pages: 1095-1102
• [Journal Article] Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice (2005)
  • Author(s): Yamamoto, K., Sokabe, T., Matsumoto, T., Yoshimura, K., Shibata, M., Ohura, N., Fukuda, T., Sato, T., Sekine, K., Kato, S., Isshiki, M., Fujita, T., Masuda, H., Kobayashi, M., Kawamura, K., Kamiya, A., Ando, J.
  • Journal Title: Nature Medicine 12 Pages: 133-137