Functional analysis of BRCA1 and BRCA2 on the mechanism of breast carcinogenesis.

• Project/Area Number: 17013027
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MIKI Yoshio Tokyo Medical and Dental University, 難治疾患研究所, 教授 (10281594)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥53,500,000 (Direct Cost: ¥53,500,000); Fiscal Year 2009: ¥10,700,000 (Direct Cost: ¥10,700,000); Fiscal Year 2008: ¥10,700,000 (Direct Cost: ¥10,700,000); Fiscal Year 2007: ¥10,700,000 (Direct Cost: ¥10,700,000); Fiscal Year 2006: ¥10,700,000 (Direct Cost: ¥10,700,000); Fiscal Year 2005: ¥10,700,000 (Direct Cost: ¥10,700,000)
• Keywords: 乳腺発がん / BRCA1 / BRCA2 / DNA損傷修復 / 中心体制御 / 細胞質分裂 / 遺伝性乳がん / BRCA1,BRCA2 / Plectin / NMHC IIC / BRCA1, BRCA2 / 14-3-3 / BJ-HCC-20A / 乳癌 / 癌精巣抗原 / アポトーシス誘導 / 核外移行シグナル / 遺伝性乳癌 / 中心体 / 中心体複製 / Plk1 / リン酸化BRCA2 / 中心体移行シグナル / γ-チューブリン

Research Abstract

When we elucidate the molecular mechanism of breast oncogenesis, the functional analysis of BRCA1 and BRCA2 which are responsible protein for hereditary breast cancer is indispensable. BRCA2 functions in DNA damage repair at S phase, and is localized, surrounding around entrosome from the G1/S transition to the early M phase of the cell cycle. When the cytokinesis begins, BRCA2 is localized in the mid-body. Therefore, we tried to clarify the role of BRCA2 protein, and find out how BRCA2 contributes to incidence of breast cancer.

Research Products

• [Journal Article] Introduction and characterization of a polymerase-dead point mutation into the POLK gene in vertebrates. (2009)
  • Author(s): Takenaka, K., Miki, Y
  • Journal Title: FEBS Lett 583 Pages: 661-4
• [Journal Article] DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter. (2009)
  • Author(s): Liu, H., Hew, H.C., Lu, Z.G., Yamaguchi, T., Miki, Y. *, Yoshida, K
  • Journal Title: Biochem J 422 Pages: 543-51
• [Journal Article] Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha. (2009)
  • Author(s): Lu, Z.G., Liu, H., Yamaguchi, T., Miki, Y. *, Yoshida, K.
  • Journal Title: Cancer Res 69 Pages: 5927-35
• [Journal Article] Pim-1 controls NF-kappaB signalling by stabilizing RelA/p65 (2009)
  • Author(s): Nihira, K., Ando, Y., Yamaguchi, T., Kagami, Y., Miki, Y, Yoshida, K.
  • Journal Title: Cell Death Differ
• [Journal Article] BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization. (2009)
  • Author(s): Niwa, T., Saito, H., Imajoh-ohmi, S., Kaminishi, M., Seto, Y., Miki, Y. *, Nakanishi, A
  • Journal Title: Cancer Sci 100 Pages: 2115-25
  • NAID: 10027197002
• [Journal Article] ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. (2009)
  • Author(s): Taira, N., Yamamoto, H., Yamaguchi, T., Miki, Y. *, Yoshida, K
  • Journal Title: J Biol Chem (Epub ahead of print)
• [Journal Article] Abnormal collagen deposition in fibromas from patient with juvenile hyaline fibromatosis. (2009)
  • Author(s): Tanaka K, Ebihara T, Kusubata M, Adachi E, Arai M, Kawaguchi N, Utsunomiya J, Miki Y, Hiramoto M, Hattori S, Irie S
  • Journal Title: J Dermatol Sci 55(3 Pages: 197-200
  • NAID: 10029371887
• [Journal Article] Introduction and characterization of a polymerase-dead point mutation into the POLK gene in vertebrates (2009)
  • Author(s): Takenaka K., et al.
  • Journal Title: FEBS Lett 583 Pages: 661-664
  • Peer Reviewed
• [Journal Article] BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization (2009)
  • Author(s): Niwa T., et al.
  • Journal Title: Cancer Sci 100 Pages: 2115-2125
  • Peer Reviewed
• [Journal Article] ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage (2009)
  • Author(s): Taira N., et al.
  • Journal Title: J Biol Chem. 285 Pages: 4904-4919
  • Peer Reviewed
• [Journal Article] A CRM1-mediated nuclear export signal governs cytoplasmic localization of BRCA2 and is essential for centrosomal localization of BRCA2. (2008)
  • Author(s): Han, X., Saito, H., Miki, Y., *, Nakanishi, A
  • Journal Title: Oncogene 27 Pages: 2969-77
• [Journal Article] Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC-associated familial predisposition to cancer. (2008)
  • Author(s): Hirai, Y., Banno, K., Suzuki, M., Ichikawa, Y., Udagawa, Y., Sugano, K., Miki, Y
  • Journal Title: Cancer Sci 99 Pages: 1715-9
• [Journal Article] IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis. (2008)
  • Author(s): Isomura, M., Oya, N., Tachiiri, S., Kaneyasu, Y., Nishimura, Y., Akimoto, T., Hareyama, M., Sugita, T., Mitsuhashi, N., Yamashita, T., Aoki, M., Sai, H., Hirokawa, Y., Sakata, K., Karasawa, K., Tomida, A., Tsuruo, T., Miki, Y., * Noda, T., Hiraoka, M
  • Journal Title: Clin Cancer Res 14 Pages: 6683-9
• [Journal Article] A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress. (2008)
  • Author(s): Kimura, J., Nguyen, S.T., Liu, H., Taira, N., Miki, Y., *, Yoshida, K
  • Journal Title: Nucleic Acids Res 36 Pages: 5250-9
• [Journal Article] Identification of novel deletion polymorphisms in breast cancer. (2008)
  • Author(s): Komatsu, A., Nagasaki, K., Fujimori, M., Amano, J., Miki, Y
  • Journal Title: Int J Oncol 33 Pages: 261-70
• [Journal Article] Molecular prediction of the therapeutic response to neoadjuvant chemotherapy in breast cancer. (2008)
  • Author(s): Nagasaki, K., Miki, Y
  • Journal Title: Breast Cancer 15 Pages: 117-20
  • NAID: 10025371689
• [Journal Article] TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress. (2008)
  • Author(s): Nihira, K., Taira, N., Miki, Y., * Yoshida, K
  • Journal Title: Oncogene 27 Pages: 7285-95
• [Journal Article] Identification of the molecular mechanisms for dedifferentiation at the invasion front of colorectal cancer by a gene expression analysis. (2008)
  • Author(s): Oku, Y., Shimoji, T., Takifuji, K., Hotta, T., Yokoyama, S., Matsuda, K., Higashiguchi, T., Tominaga, T., Nasu, T., Tamura, K., Matsuura, M., Miyata, S., Kato, Y., Yamaue, H., Miki, Y
  • Journal Title: Clin Cancer Res 14 Pages: 7215-22
• [Journal Article] BRCA1-mediated ubiquitination inhibits topoisomerase II alpha activity in response to oxidative stress. (2008)
  • Author(s): Shinagawa, H., Miki, Y., * Yoshida, K.
  • Journal Title: Antioxid Redox Signal 10 Pages: 939-49
• [Journal Article] Recurrence pattern and rapid intraoperative detection of carcinoembryonic antigen (CEA) mRNA in pleural lavage in patients with non-small cell lung cancer (NSCLC) (2008)
  • Author(s): Sugai, S., Satoh, Y., Komatsu, M., Okumura, S., Nakagawa, K., Ishikawa, Y., Miki, Y
  • Journal Title: Rinsho Byori 56 Pages: 851-7
  • NAID: 10024960497
• [Journal Article] Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer. (2008)
  • Author(s): Sugano, K., Nakamura, S., Ando, J.,Takayama, S., Kamata, H., Sekiguchi, I.,Ubukata, M., Kodama, T., Arai, M., Kasumi,F., Hirai, Y., Ikeda, T., Jinno, H.,Kitajima, M., Aoki, D., Hirasawa, A.,Takeda, Y., Yazaki, K., Fukutomi, T.,Kinoshita, T., Tsunematsu, R., Yoshida, T.,Izumi, M., Umezawa, S., Yagata, H.,Komatsu, H., Arimori, N., Matoba, N.,Gondo, N., Yokoyama, S., Miki, Y.
  • Journal Title: Cancer Sci 99 Pages: 1967-76
  • NAID: 10024011931
• [Journal Article] Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy. (2008)
  • Author(s): Tanaka, S., Arii, S., Yasen, M., Mogushi, K., Su, N.T., Zhao, C., Imoto, I., Eishi, Y., Inazawa, J., Miki, Y., Tanaka, H
  • Journal Title: Br J Surg 95 Pages: 611-9
• [Journal Article] Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage. (2008)
  • Author(s): omiyoshi, G., Nakanishi, A., Takenaka, K., Yoshida, K., Miki, Y
  • Journal Title: Cancer Sci 99 Pages: 747-54
  • NAID: 10024004963
• [Journal Article] A CRM1-mediated nuclear export signal governs cytoplasmic localization of BRC A2 and is essential for centrosomal localization of BRCA2 (2008)
  • Author(s): Hari, X., et.al.
  • Journal Title: Oncogene 27 Pages: 2969-77
  • Peer Reviewed
• [Journal Article] Molecular epidemiological and mutational analysis of DNA mismatch repair (MMR) genes in endometrial cancer patients with HNPCC-associated familial predisposition to cancer (2008)
  • Author(s): Hirai, Y., et.al.
  • Journal Title: Cancer Sci 99 Pages: 1715-9
  • Peer Reviewed
• [Journal Article] IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis (2008)
  • Author(s): Isomura, M., et.al.
  • Journal Title: Clin Cancer Res 14 Pages: 6683-9
  • Peer Reviewed
• [Journal Article] Identification of novel deletion plymorphisms in breast cancer (2008)
  • Author(s): Komatsu, A., et.al.
  • Journal Title: Int J Oncol 33 Pages: 261-70
  • Peer Reviewed
• [Journal Article] Identification of the molecular mechanisms for dedifferentiation at the invasion front of colorectal cancer by a gene expression analysis (2008)
  • Author(s): Oku, Y, et.al.
  • Journal Title: Clin Cancer Res 14 Pages: 7215-22
  • Peer Reviewed
• [Journal Article] Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer (2008)
  • Author(s): Sugano, K., et.al.
  • Journal Title: Cancer Sci 99 Pages: 1967-76
  • Peer Reviewed
• [Journal Article] Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage (2008)
  • Author(s): Tomiyoshi, G, et.al.
  • Journal Title: Cancer Sci 99 Pages: 747-54
  • Peer Reviewed
• [Journal Article] Frequent reduced expression of alpha-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers. (2007)
  • Author(s): Noda H, et. al.
  • Journal Title: Br J Cancer. 96 Pages: 363-390
  • Peer Reviewed
• [Journal Article] Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division. (2007)
  • Author(s): Nakanishi A, et. al.
  • Journal Title: Biochem Biophys Res Commun. 355 Pages: 34-40
  • Peer Reviewed
• [Journal Article] DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. (2007)
  • Author(s): Taira N, et. al.
  • Journal Title: Mol Cell. 25 Pages: 725-738
  • Peer Reviewed
• [Journal Article] Reduced Levels of ATF-2 Predispose Mice to Mammary Tumors. (2007)
  • Author(s): Maekawa T, et al.
  • Journal Title: Mol Cell Biol. 27 (5) Pages: 1730-1744
• [Journal Article] Frequent reduced expression of alpha-IB-adrenergic receptor caused by aberrant promoter methylation in gastric cancers. (2007)
  • Author(s): Noda H, et al.
  • Journal Title: Br J Cancer. 96 (2) Pages: 383-390
• [Journal Article] Functional pathway characterized by gene expression analysis of supraclavicular lymph node metastasis-positive breast cancer (2007)
  • Author(s): Oishi Y, et al.
  • Journal Title: J Hum Genet 52 (3) Pages: 271-279
• [Journal Article] Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division. (2007)
  • Author(s): Nakanishi A, et al.
  • Journal Title: Biochem Biophys Res Commun. 355 (1) Pages: 34-40
• [Journal Article] DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. (2007)
  • Author(s): Taira N, et al.
  • Journal Title: Mol Cell. 25 (5) Pages: 725-738
• [Journal Article] Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma. (2007)
  • Author(s): Nguyen ST, et al.
  • Journal Title: Cancer Sci. 28
• [Journal Article] Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. (2006)
  • Author(s): Yoshida K, et al.
  • Journal Title: J Biol Chem. 26 (9) Pages: 3414-3431
• [Journal Article] Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers. (2006)
  • Author(s): Noda H, et al.
  • Journal Title: J Exp Clin Cancer Res. 25 (2) Pages: 235-242
• [Journal Article] Accelerated growth of intestinal tumours after radiation exposure in MIhl-knockout mice : evaluation of the late effect of radiation on a mouse model of HNPCC. (2006)
  • Author(s): Tokairin Y, et al.
  • Journal Title: Int J Exp Pathol. 87 (2) Pages: 89-99
• [Journal Article] Frequency of immunohistochemical loss of mismatch repair protein in double primary cancers of the colorectum and stomach in Japan. (2006)
  • Author(s): Hayashi T, et al.
  • Journal Title: Dis Colon Rectum 49(10 Suppl) Pages: 23-29
• [Journal Article] JNK phosphorylation of 14-3-3 regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (2005)
  • Author(s): Yoshida K
  • Journal Title: Nat Cell Biol. 7 Pages: 278-285
• [Journal Article] Microsatellite instability caused by hMLH1 promoter methylation increases with tumor progression in right-sided sporadic colorectal cancer. (2005)
  • Author(s): Noda H
  • Journal Title: Oncology 69 Pages: 354-362
• [Journal Article] Postoperative prognosis of node-negative breast cancers predicted by gene-expression profiling on a cDNA microarray of 25,344 genes. (2005)
  • Author(s): Tsumagari K
  • Journal Title: Breast Cancer 12 Pages: 166-177
• [Journal Article] Enabling death by the Abl tyrosine kinase : mechanisms for nuclear shuttling of c-Abl in response to DNA damage. (2005)
  • Author(s): Yoshida K
  • Journal Title: Cell Cycle 4 Pages: 777-779
• [Journal Article] Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.
  • Author(s): Yoshida K
  • Journal Title: J Biol Chem. In press
• [Journal Article] Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage.
  • Author(s): Yoshida K
  • Journal Title: Mol.Cell.Biol. In press
• [Presentation] Molecular prediction of therapeutic response and adverse effect of chemotherapy in breast cancer (2009)
  • Author(s): Miki Y.
  • Organizer: Institute for Genetic Medicine, Hokkaido University, Research Center for Infection-associated Cancer(RCIAC), International Symposium New Frontiers in Cancer Research
  • Place of Presentation: Hokkaido Japan
  • Year and Date: 2009-03-18
• [Presentation] 乳がん治療の個別化病態に応じた治療法の最近の進歩遺伝子診断による個別化乳癌術前化学療法(Personalized breast cancer therapy: recent adwanees in breast cancer therapy tailored to individual clinical conditions Individualized primary chemotherapy by genetic diagnosis for breast cancer). (2009)
  • Author(s): 伊藤良則;三木義男;秋山太;松浦正明;長崎光一;岩瀬拓士;畠清彦
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] パクリタキセルの末梢神経障害を予測する遺伝的マーカーの探索(Genome wide association study to identify genetic marker for prediction of peripheral neuropathy of paclitaxel treatment). (2009)
  • Author(s): 磯村実;松浦正明;野田哲生;三木義男
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 乳がんと膵がんに関連するヒトがん幹細胞の分子学的特性解析(Molecular characterization of human cancer stem cells-associated breast and pancreatic carcinoma). (2009)
  • Author(s): 塩谷尚志;河口徳一;菅原稔;長崎光一;磯村実;牛嶋大;松浦正明;三木義男;野田哲生
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 乳癌の新規予後因子の同定. (2009)
  • Author(s): 吉村慶子;長埼光一;岩瀬拓士;秋山太;三木義男
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: 東京
• [Presentation] 分子生物学的手法による高分化型脂肪肉腫の鑑別診断の試み. (2009)
  • Author(s): 五木田茶舞;阿江啓介;下地尚;石田剛;松本誠一;三木義男;四宮謙一
  • Organizer: 第82回日本整形外科学会学術総
  • Place of Presentation: 福岡
• [Presentation] 乳癌における治療効果予測因子の現状と今後の展望化学療法の効果予測因子基 礎の立場から(シンポジウム). (2009)
  • Author(s): 三木義男;牛嶋大;松浦正明;長崎光一
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: 東京
• [Presentation] Brca2は14-3-3γと結合して中心体の凝集に関与する. (2009)
  • Author(s): 三木義男;中西啓
  • Organizer: 第15回日本家族性腫瘍学会学術集会
  • Place of Presentation: 東京
• [Presentation] 分子情報を用いた個別化医療のTR乳がんの抗がん剤治療効果予測法の開発(Translational research for personalized medicine based on genome information of cancer patients Genomic study for response prediction of breast cancer chemotherapy)(シンポジウム). (2009)
  • Author(s): 三木義男;長崎光一;牛嶋大;宮田敏;松浦正明;野田哲生
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 乳癌における新規遺伝子多型の同定. (2009)
  • Author(s): 小松哲;長崎光一;篠原剛;五十嵐淳;藤森芳郎;山岸喜代文;西村博行;藤森実;三木義男
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] Pim-1はRelA/p65のSer276をリン酸化することでNF-κBの活性化を制御する(Pim-1 kinase controls the transcription activity of NF-kappaB through phosphorylation of the RelA/p65 subunit at Ser276). (2009)
  • Author(s): 仁平啓史;三木義男;吉田清嗣
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 原発性非小細胞肺癌切除時の胸腔内洗浄液におけるTRC法によるCEA mRNAとCK19 mRNAの迅速的検出の検討(Rapid intraoperative detection of CEA mRNA and CK19 mRNA in the pleural lavage of NSCLCs by the TRC method). (2009)
  • Author(s): 須貝幸子;坂尾幸則;文敏景;奥村栄;尾本大輔;大仲悟;林俊典;小松美樹;石川雄一;佐藤之俊, others.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 細胞周期に関連する網羅的リン酸化タンパクの定量解析(Comprehensive phosphoproteome analysis during the cell cycle of Hela S3 cells). (2009)
  • Author(s): 斉藤広子;中西啓;三木義男
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 遺伝カウンセリング後のhnpcc患者・家族の近親者への医療機関受診勧奨支援の重要性について. (2009)
  • Author(s): 石井紀子;新井正美;三木義男
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: 東京
• [Presentation] 乳がんにおけるstmn1高発現症例の病理学的特徴. (2009)
  • Author(s): 大石陽子;三浦妙太;佐原八束;川村徹;佐藤康;中嶋昭;三木義男
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: 東京
• [Presentation] BRCA2- Myosin IIC complex is localized to the midbody of cytokinesis and required the completion of cytokinesis (2009)
  • Author(s): 中西啓;斉藤広子;大海忍;福田宏之;高村千鶴子;三木義男
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] トランスフェクションアレイを用いた薬剤感受性遺伝子の機能ネットワーク解析(Functional Screening for Chemo-sensitivity Related Genes by Transfection Cell Array). (2009)
  • Author(s): 長崎光一;下地尚;星川裕;松浦正明;野田哲生;三木義男
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 肝癌再発ネットワーク解析に基づくAurora kinase B分子標的治療の開発(Aurora kinase B addiction as a novel molecular target in hepatocellular carcinoma with aggressive recurrence). (2009)
  • Author(s): 田中真二;藍原有弘;茂櫛薫;ヤーセン・マームット;野口典男;入江工;工藤篤;中村典明;井本逸勢;三木義男, others.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] ATMによるDYRK2のリン酸化はMDM2を介したユビキチン化の阻害に必要である(ATM phosphorylation of DYRK2 confers resistance to ubiquitination-mediated degradation by MDM2). (2009)
  • Author(s): 平直江;三木義男;吉田清嗣
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] ライブラリー型RNA干渉を用いたアポトーシス誘導関連遺伝子の網羅的探索(The functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in human cancer cells). (2009)
  • Author(s): 木村純子;平直江;三木義男;吉田清嗣
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 遺伝性乳癌卵巣癌が疑われる日本人を対象とするBRCA1/2遺伝子変異の横断的研究 (2008)
  • Author(s): 菅野康吉, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 遺伝性子宮体癌の臨床的検討 (2008)
  • Author(s): 平井康夫, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] 新規BRCA2結合タンパク質BJ-HCC-20AはDNA損傷に応答したアポトーシス誘導を抑制する (2008)
  • Author(s): 冨吉郷, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] 乳癌の化学療法感受性予測の試み (2008)
  • Author(s): 三木義男, 他
  • Organizer: 第16回日本乳癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-26
• [Presentation] Stathmin 1染色を用いた予後予測と抗がん剤感受性予測の検討 (2008)
  • Author(s): 大石陽子, 他
  • Organizer: 第16回日本乳癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-26
• [Presentation] BRCA2-Plectin複合体は中心体の固定に関与する (2008)
  • Author(s): 三木義男, 他
  • Organizer: 第14回日本家族性腫瘍学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-20
• [Presentation] 乳がん術前化学療法の効果予測システム開発の試み (2008)
  • Author(s): 三木義男
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2008-05-15
• [Presentation] Establishment of a Personalized Chemotherapy for Breast Cancer. (2007)
  • Author(s): Miki Y, et. al.
  • Organizer: Seventh AACR/JCA Joint International Conference
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2007-01-25
• [Book] がんの分子標的 (2008)
  • Author(s): 磯村実、三木義男
  • Total Pages: 5
  • Publisher: 遺伝子多型解析
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/mgen/index_j.html
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/mgen/index_j.html
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/mgen/index_j.html