FUNCTIONAL ANALYSIS OF CANCER-SUSCEPTIBIE GENE, NBS1
| Project/Area Number |
17013040
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
KOMATSU Kenshi Kyoto University, 放射線生物研究センター, 教授 (80124577)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Junya 京都大学, 放射線生物研究センター, 助教 (30301302)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥82,000,000 (Direct Cost: ¥82,000,000)
Fiscal Year 2009: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2008: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2007: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2006: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2005: ¥16,400,000 (Direct Cost: ¥16,400,000)
|
|---|
| Keywords | DNA二重鎖切断 / NBSI,BRCAI,中心体 / 相同組換え / シスプラチン増感 / NBS1 / ヒストンユビキチン化 / 中心体 / NBS / BRCA1 / ATM / 非相同末端再結合 / ICL修復 / ビオチン標識 / ソラーレン / ファンコニー貧血 / 相同組み換え / ナイミーヘン症候群 / 毛細血管拡張性運動失調症 / チェックポイント / 複製ストレス / がん化 |
|---|
| Research Abstract |
We showed here that NBS1 is involved in human homologous recombination. Contrast to other underlying genes of radiation sensitive genetic syndrome, such as ATM and BRCA1, NBS1 functions in early step of homologous recombination. In addition, we revealed that NBS1 binds to TOPBP1, which is an important factor for activation of ATR, and disruption of NBS1 leads to enhanced sensitivity to UV and anti-tumor drug, cis-platin. Furthermore, we showed that NBS1 has critical role in genome stability through maintaining centrosomes.
|
Report
(6 results)
Research Products
(76 results)
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Ono T. Absence of Ku70 gene obliterates X-ray-induced lacZ mutagenesis of small deletions in mouse tissues.2008
Author(s)
Uehara Y, Ikehata H, Komura J, Ito A, Ogata M, Itoh T, Hirayama R, Furusawa Y, Ando K, Paunesku T, Woloschak GE, Komatsu K, Matsuura S, Ikura T, Kamiya K
-
Journal Title
Radiat Res. 170
Pages: 216-223
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Monoallelic BUB1B Mutations and Defective Mitotic-Spindle Checkpoint in Seven Families With Premature Chromatid Separation (PCS) Syndrome.2006
Author(s)
S. Matsuura, Y. Matsumoto, K. Morishima, H. Izumi, H. Matsumoto, E. Ito, K. Tsutsui, J. Kobayashi, H. Tauchi, Y. Kajiwara, S. Hama, K. Kurisu, H. Tahara, M. Oshimura, K. Komatsu, Tatsuro Ikeuchi, Tadashi Kajii.
-
Journal Title
Amer J Med Genet. 140(4)
Pages: 358-67
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Fanconi Anemia protein FANCD2 promotes Thompson LH and Takata M. immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination.2005
Author(s)
Yamamoto K, Hirano S, Ishiai M, Morishima K, Kitao H, Kimura M, Namikoshi K, Matsushita N, Arakawa H, Buerstedde JM, Komatsu K, Thompson LH, Takata M.
-
Journal Title
Mol. Cell. Biol. 25
Pages: 34-43
Related Report
Peer Reviewed
-
-
[Journal Article] Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage2005
Author(s)
Chen L, Morio T, Minegishi Y, Nakada S, Nagasawa M, Komatsu K, Chessa L, Villa A, Lecis D, Delia D, Mizutani S.
-
Journal Title
Cancer Science 96
Pages: 134-141
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
