| Budget Amount *help |
¥82,000,000 (Direct Cost: ¥82,000,000)
Fiscal Year 2009: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2008: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2007: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2006: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2005: ¥16,400,000 (Direct Cost: ¥16,400,000)
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| Research Abstract |
We showed here that NBS1 is involved in human homologous recombination. Contrast to other underlying genes of radiation sensitive genetic syndrome, such as ATM and BRCA1, NBS1 functions in early step of homologous recombination. In addition, we revealed that NBS1 binds to TOPBP1, which is an important factor for activation of ATR, and disruption of NBS1 leads to enhanced sensitivity to UV and anti-tumor drug, cis-platin. Furthermore, we showed that NBS1 has critical role in genome stability through maintaining centrosomes.
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