Carcinogenesis by a genome mutator AID
Project/Area Number |
17013042
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Research Institute, Shiga Medical Center |
Principal Investigator |
KINOSHITA Kazuo Research Institute, Shiga Medical Center, 遺伝子研究部門, 専門研究員 (50293874)
|
Project Period (FY) |
2005 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥48,500,000 (Direct Cost: ¥48,500,000)
Fiscal Year 2009: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2008: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2007: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2006: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2005: ¥9,700,000 (Direct Cost: ¥9,700,000)
|
Keywords | AID / 発がん / 感染 / 慢性炎症 / 突然変異 / 肝臓がん / 皮膚がん / 体細胞突然変異 / クラススイッチ組換え / Creリコンビナーゼ |
Research Abstract |
免疫に関わる抗体の遺伝子に変異を入れて多様な抗体を作る酵素AIDが偶発的に抗体以外の遺伝子に変異を導入することにより発がんに至るという仮説を支持する以下の結果が得られた。(1) 肝炎ウイルスによる肝がんやピロリ菌による胃がんにAIDが存在している、(2) 肝臓でAIDが作られるマウスを遺伝子工学により作製すると肝臓がんが発症した。(3) AIDのないマウスでは実験的皮膚がんが起こりにくかった。
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Report
(6 results)
Research Products
(40 results)
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[Journal Article] A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.2009
Author(s)
Takai, A, Toyoshima, T, Uemura, M, Kitawaki, Y, Marusawa, H, Hiai, H, Yamada, S, Okazaki, IM, Honjo, T, Chiba, T, Kinoshita, K.
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Journal Title
Oncogene 28
Pages: 469-478
Related Report
Peer Reviewed
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[Journal Article] Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.2009
Author(s)
Nonaka, T, Doi, T, Toyoshima, T, Muramatsu, M, Honjo, T, Kinoshita, K.
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Journal Title
Proc Natl Acad Sci U S A 106
Pages: 2747-51
Related Report
Peer Reviewed
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[Journal Article] Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma.2008
Author(s)
Komori, J, Marusawa, H, Machimoto, T, Endo, Y, Kinoshita, K, Kou, T, Haga, H, Ikai, I, Uemoto, S, Chiba, T.
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Journal Title
Hepatology 47
Pages: 888-896
Related Report
Peer Reviewed
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[Journal Article] Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers.2008
Author(s)
Endo, Y, Marusawa, H, Kou, T, Nakase, H, Fujii, S, Fujimori, T, Kinoshita, K, Honjo, T, Chiba, T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Helicobacter pylori infection triggers aberrant expression of activation- induced cytidine deaminase in gastric epithelium.2007
Author(s)
Matsumoto, Y, Marusawa, H, Kinoshita, K, Endo, Y, Kou, T, Morisawa, T, Azuma, T, Okazaki, IM, Honjo, T, Chiba, T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Ectopic expression of activation- induced cytidine deaminase in ulcerative colitis-associated colorectal cancers.2007
Author(s)
Kou, T, Marusawa, H, Endo, Y, Nakase, H, Fujii, S, Kinoshita, K, Fujimori, T, Honjo, T, Chiba, T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.2007
Author(s)
Kotani, A, Kakazu, N, Tsuruyama, T, Okazaki, IM, Muramatsu, M, Kinoshita, K, Nagaoka, H, Yabe, D, Honjo, T.
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Journal Title
Proc Natl Acad Sci U S A 104
Pages: 1616-20
Related Report
Peer Reviewed
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[Journal Article] High expression of activation induced cytidine deaminase in human bile duct epithelium during cholangiocarcinogenesis.2007
Author(s)
Komori, J, Marusawa, H, Machimoto, T, Endo, Y, Kinoshita, K, Kou, T, Haga, H, Ikai, I, Uemoto, S, Honjo, T, Chiba, T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling.2007
Author(s)
Endo, Y, Marusawa, H, Kinoshita, K, Morisawa, T, Sakurai, T, Okazaki, IM, Watashi, K, Shimotohno, K, Honjo, T, Chiba, T.
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Journal Title
Oncogene 26
Pages: 5587-95
Related Report
Peer Reviewed
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[Journal Article] Negative regulation of activation- induced cytidine deaminase in B cells.2006
Author(s)
Muto, T, Okazaki, IM, Yamada, S, Tanaka, Y, Kinoshita, K, Muramatsu, M, Nagaoka, H, Honjo, T.
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Journal Title
Proc Natl Acad Sci U S A 103
Pages: 2752-2757
Related Report
Peer Reviewed
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[Journal Article] Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis.2006
Author(s)
Kou, T, Marusawa, H, Kinoshita, K, Endo, Y, Okazaki, IM, Ueda, Y, Kodama, Y, Haga, H, Ikai, I, Chiba, T.
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Journal Title
Int J Cancer 120
Pages: 469-76
Related Report
Peer Reviewed
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